CAS 1257044-40-8

ABT-199

Descrição:

ABT-199, também conhecido como Venetoclax, é um inibidor de moléculas pequenas projetado principalmente para direcionar a proteína do linfoma B 2 (BCL-2), que desempenha um papel crucial na regulação da apoptose (morte celular programada). Este composto é caracterizado por sua capacidade de se ligar seletivamente ao BCL-2, promovendo assim a apoptose de células cancerosas que superexpressam essa proteína, particularmente em certos tipos de malignidades hematológicas, como leucemia linfocítica crônica (LLC) e leucemia mieloide aguda (LMA). ABT-199 exibe um alto grau de especificidade para BCL-2 em relação a outras proteínas da família BCL-2, o que contribui para sua eficácia terapêutica e perfil de segurança. A substância é administrada por via oral e tem sido associada a vários efeitos colaterais, incluindo neutropenia e síndrome de lise tumoral, exigindo monitoramento cuidadoso durante o tratamento. Seu desenvolvimento marcou um avanço significativo nas terapias direcionadas ao câncer, proporcionando uma abordagem nova para tratar malignidades que são resistentes a terapias convencionais. No geral, ABT-199 representa um avanço crítico no campo da oncologia, particularmente para pacientes com cânceres específicos dependentes de BCL-2.

Fórmula: C₄₅H₅₀ClN₇O₇S

InChI: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

Chave InChI: InChIKey=LQBVNQSMGBZMKD-UHFFFAOYSA-N

SMILES: C(C1=C(CC(C)(C)CC1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC(OC=5C=C6C(=NC5)NC=C6)=C(C(NS(=O)(=O)C7=CC(N(=O)=O)=C(NCC8CCOCC8)C=C7)=O)C=C4

Sinónimos:

• 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
• Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
• Gdc-0199
• Rg 7601
• Rg7601
• Venclexta
• Venclyxto
• Venetoclax
• ABT 199
• 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsulfonyl)benzamide
• GDC0199
• ABT199,GDC0199
• 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide ABT-199 (GDC-0199)

4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(oxan-4-ylmethyl)amino]benzene}sulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide

CAS: 1257044-40-8

Fórmula: C₄₅H₅₀ClN₇O₇S

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 868.4392

Ref: IN-DA000OIU

Venetoclax

CAS: 1257044-40-8

Fórmula: C₄₅H₅₀ClN₇O₇S

Cor e Forma: Yellow Solid

Peso molecular: 868.45

Ref: 4Z-V-064001

Venetoclax

CAS: 1257044-40-8

Venetoclax

Pureza: ≥98%

Peso molecular: 868.44g/mol

Ref: 54-BUP16820

Venetoclax-d8 (piperazine-d8)

CAS: 1257044-40-8, 1257051-06-1

Pureza: 98 atom % D

Peso molecular: 875.36

Ref: 3U-D8267

Venetoclax

CAS: 1257044-40-8

Venetoclax (ABT-199) is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to Bcl-xL, and Bcl-W (Kis = 48/245 nM).

Fórmula: C₄₅H₅₀ClN₇O₇S

Pureza: 98.00% - 99.97%

Cor e Forma: Solid

Peso molecular: 868.44

Ref: TM-T2119

Venetoclax

CAS: 1257044-40-8

Fórmula: C₄₅H₅₀ClN₇O₇S

Peso molecular: 868.45

Ref: ST-EA-CP-V17000

ABT 199 (>99%)(Venetoclax)

Produto Controlado

CAS: 1257044-40-8

Applications ABT 199 (>99%) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

Fórmula: C₄₅H₅₀ClN₇O₇S

Cor e Forma: Light Yellow To Yellow

Peso molecular: 868.44

Ref: TR-A112425

ABT 199 (Venetoclax)

Produto Controlado

CAS: 1257044-40-8

Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

Fórmula: C₄₅H₅₀ClN₇O₇S

Cor e Forma: Light Yellow To Yellow

Peso molecular: 868.44

Ref: TR-A112430

Venetoclax

CAS: 1257044-40-8

A BCL-2 selective inhibitor with no effect on Bcl-xl and thereby prevents thrombocytopenia. Increased sensitivity observed in Bcl-2-dependent haematological tumour cell lines. Elicits additional benefits to tamoxifen treatment in ER-positive breast cancer xenografts.

Fórmula: C₄₅H₅₀ClN₇O₇S

Pureza: Min. 98 Area-%

Cor e Forma: Yellow Powder

Peso molecular: 868.44 g/mol

Ref: 3D-FV63222

ABT-199-D10

Produto Controlado

CAS: 1257044-40-8

Applications ABT-199-D10 is a deuterized form of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumor activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

Fórmula: C₄₅D₁₀H₄₀ClN₇O₇S

Cor e Forma: Neat

Peso molecular: 878.5

Ref: TR-A112432