CAS 1263-89-4

Sulfato de paromomicina

Descrição:

Sulfato de paromomicina é um antibiótico aminoglicosídeo usado principalmente para tratar infecções causadas por certos tipos de bactérias, particularmente em casos de amebíase intestinal e leishmaniose. É derivado da bactéria Streptomyces griseus e funciona inibindo a síntese de proteínas em microrganismos suscetíveis. O composto é caracterizado pela sua capacidade de se ligar à subunidade ribossomal 30S, levando à leitura incorreta do mRNA e, em última análise, interrompendo o crescimento bacteriano. A paromomicina é tipicamente administrada por via oral ou parenteral, dependendo da infecção que está sendo tratada. É conhecida por sua toxicidade relativamente baixa em comparação com outros aminoglicosídeos, embora ainda possa causar efeitos colaterais, como distúrbios gastrointestinais e nefrotoxicidade em alguns casos. A forma sulfato melhora sua solubilidade em água, tornando-a adequada para várias formulações. A paromomicina também está sendo investigada por seu potencial uso no tratamento de infecções multirresistentes, destacando sua importância no campo da terapia antimicrobiana.

Fórmula: C₂₃H₄₇N₅O₁₈S

InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23?;/m1./s1

Chave InChI: InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Sinónimos:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
• (2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• 1600 Antibiotic
• 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Aminosidin sulfate
• Aminosidin sulphate
• Aminosidine Sulphate
• Aminosidine sulfate
• Aminoxidin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Farmiglucin
• Farminosidin
• Fi 5853
• Gabbroral
• Humagel
• Humatin
• Humycin sulfate
• O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine sulfate (salt)
• Paramicina
• Pargonyl
• Paricina
• Paromomycin Sulphate
• Paromomycin Sulphates
• Paromomycin sulfate salt
• Paromomycinsulfate
• Sinosid
• Sulfates De Paromomycine
• Sulfatos De Paromomicina
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• Paromomycin sulfate
• D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI)
• fi5853
• PayoMoMycin Sulfate
• Paromomycin sulphate solution,1000ppm solution
• Barone sulfate kanamycin Solution, 100ppm
• humycinsulfate
• Humatin (tn)
• Paromomycin sulfate (jan/usp)
• O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
• sulf
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI)
• Paromomycin sulphate solution,100ppm
• aminosidinesulfate
• PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+%
• Paromomycin Sulfate (125 mg)
• paromomycin sulfate cell culture tested
• Paromomycin Sufate
• paromomycin sulfate plant cell*culture tested
• streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof
• NEOMYCIN E
• aminosidinesulphate
• Paramomycinsulfate
• O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate
• aminosidinsulfate
• O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate
• D00868
• PAROMOMYCIN SULFATE USP 97+%
• Paromomycin sulfate ,98%
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Pureza: >92.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin sulfate

CAS: 1263-89-4

Inhibits initiation and elongation during protein synthesis

Fórmula: C₂₃H₄₇N₅O₁₈S

Cor e Forma: White to pale cream to pale yellow, Powder

Peso molecular: 713.71

Ref: 02-J61274

PAROMOMYCIN SULFATE RS

CAS: 1263-89-4

PAROMOMYCIN SULFATE RS

Fórmula: C₂₃H₄₅N₅O₁₄

Peso molecular: 615.6285

Ref: 41-ICRS0378

Paromomycin Sulfate

CAS: 1263-89-4

Aminoglycoside antibiotics

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Cor e Forma: White Off-White Light Yellow Powder

Peso molecular: 615.2963

Ref: 45-1500003

Paromomycin sulfate

CAS: 1263-89-4

Fórmula: C₂₃H₄₇N₅O₁₈S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 713.7070

Ref: IN-DA0072SF

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate, an aminoglycoside antibiotic, binds to 30S ribosomes, disrupting protein synthesis and killing bacteria.

Fórmula: C₂₃H₄₇N₅O₁₈S

Pureza: 99.73% - 99.86%

Cor e Forma: Solid

Peso molecular: 713.71

Ref: TM-T1104

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate

Pureza: ≥98%

Peso molecular: 713.71g/mol

Ref: 54-BUP18626

Paromomycin sulfate salt

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Cor e Forma: White to off-white powder

Peso molecular: 713.71

Ref: 7W-GA4947

Paromomycin sulphate

CAS: 1263-89-4

Paromomycin sulphate

Fórmula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Pureza: Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)

Cor e Forma: white to faint yellow powder

Peso molecular: 713.71g/mol

Ref: 54-BIP0141

Paromomycin sulfate

Produto Controlado

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Cor e Forma: Neat

Peso molecular: 713.71

Ref: 04-C15893500

Paromomycin Sulfate

CAS: 1263-89-4

Stability Hygroscopic
Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Fórmula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Cor e Forma: Neat

Peso molecular: 713.71

Ref: TR-P205650

Paromomycin sulfate

CAS: 1263-89-4

Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Pureza: ≥675Μg/Mg(On Dried Basis)

Cor e Forma: Yellow Powder

Peso molecular: 615.63 g/mol

Ref: 3D-AP31110

Paromomycin sulfate, Antibiotic for Culture Media Use Only

CAS: 1263-89-4

Paromomycin sulfate is an antibiotic used for culture media to control bacterial contamination of mediums and other laboratory substances. Most Gram-negative bacteria strains are sensitive to paromomycin sulfate, showing a low sensitivity (≀10%) in Enterobacteriaceae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Serratia marcescens. Paromomycin sulfate is also used in the treatment of colorectal cancer by blocking DNA synthesis through inhibition of protein synthesis in susceptible cells. This can result in reduced damage in colon tumor cells within the body, although it may have neurotoxic effects on brain tissue. Furthermore, it has anti-inflammatory properties when given orally or intravenously at therapeutic doses. Acridine orange can be used to identify sulfuric acid resistant gram.

Fórmula: C₂₃H₄₇N₅O₁₈S

Pureza: Min. 95.0 Area-%

Peso molecular: 713.71 g/mol

Ref: 3D-Q-201537

Paromomycin Sulfate (PRM)

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Cor e Forma: White to off-white, Powder

Peso molecular: 713.17

Ref: SR-27436

Paromomycin sulfate

CAS: 1263-89-4

Pureza: 95+%

Peso molecular: 713.710022

Ref: 10-F806731

Neomycin sulfate EP Impurity E

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄H₂SO₄

Peso molecular: 615.63 : 98.07

Ref: ST-EA-CP-N53005