CAS 1264-72-8

sulfato de colistina

Descrição:

sulfato de colistina, com o número CAS 1264-72-8, é um antibiótico que pertence à classe dos antibióticos polimixina, utilizado principalmente para tratar infecções causadas por bactérias Gram-negativas. É derivado da bactéria Bacillus polymyxa e é conhecido por sua eficácia contra cepas multirresistentes. sulfato de colistina é uma mistura complexa de polipeptídeos, com colistina A e colistina E sendo os componentes mais proeminentes. A substância é caracterizada por sua natureza anfipática, permitindo-lhe interromper as membranas celulares bacterianas, levando à morte celular. sulfato de colistina é tipicamente administrado por injeção ou inalação, pois é mal absorvido pelo trato gastrointestinal. Seu uso tem sido limitado devido à potencial nefrotoxicidade e neurotoxicidade, exigindo monitoramento cuidadoso durante o tratamento. Apesar dessas preocupações, sulfato de colistina recuperou atenção nos últimos anos devido ao aumento de infecções resistentes a antibióticos, tornando-se uma opção crítica no arsenal antimicrobiano. Sua formulação como sal sulfato melhora sua solubilidade e estabilidade, facilitando seu uso em ambientes clínicos.

Fórmula: (C₅₂H₉₈N₁₆O₁₃)·5(H₂SO₄)

InChI: InChI=1/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1

Sinónimos:

• Belcomycin
• Colimycin sulfate
• Colistin Sulphate
• Colistin, Sulfat (Salz)
• Colistin, sulfate (salt)
• Colistina, Sulfato (Sal)
• Colistine, Sulfate (Sel)
• Colomycin
• Colomycin syrup
• N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-5-methylheptanamide
• N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide sulfate (1:1)
• N-[3-Amino-1-[[1-[[3-Amino-1-[[6,9,18-Tris(2-Aminoethyl)-3-(1-Hydroxyethyl)-12,15-Bis(2-Methylpropyl)-2,5,8,11,14,17,20-Heptaoxo-1,4,7,10,13,16,19-Heptazacyclotricos-21-Yl]Carbamoyl]Propyl]Carbamoyl]-2-Hydroxy-Propyl]Carbamoyl]Propyl]-5-Methyl-Heptanamide Sulfate
• Nipoxyme
• Polymyxin E sulfate
• Polymyxin E, sulfate (salt)
• Colistin sulfate
• COLISTIN SULPHATE PURE GRADE
• polymyxine Multimycine
• Colistin sulphate premix 10% 40%
• polymyxinesulfate(salt)
• Colstin sulfate
• colistinsulfat
• Belcomycine
• colomycinsyrup
• COLISTINSULFATE,POWDER,USP
• colimycinsulfate
• COLISTINE SULFATE
• Colistin sulphate premix 10%
• ColistinSulfateEp5
• Colomyci

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate, 1264-72-8, or polymyxin E complex, is a complex of antibiotics, primarily colistin A and B, which has broad-spectrum anti-bacterial activity. Learn more.

Fórmula: C₅₃H₁₀₂N₁₆O₁₇S

Cor e Forma: Powder, White to pale cream

Peso molecular: 1267.55

Ref: 02-J60915

COLISTIN SULFATE FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1264-72-8

COLISTIN SULFATE FOR MICROBIOLOGICAL ASSAY CRS

Fórmula: C₅₂H₉₈N₁₆O₁₃

Peso molecular: 1155.434

Ref: 41-C2700000

Colistin Sulfate

CAS: 1264-72-8

Antibiotics nesoi

Fórmula: ColistinAC₅₃H₁₀₀N₁₆O₁₃ColistinBC₅₂H₉₈N₁₆O₁₃

Cor e Forma: White Light Yellow Powder

Peso molecular: 1155.434

Ref: 45-1148001

Colistin (sulfate)

CAS: 1264-72-8

Fórmula: C₅₃H₁₀₂N₁₆O₁₇S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1267.5390

Ref: IN-DA000SQS

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Fórmula: C₅₃H₁₀₀N₁₆O₁₇S

Pureza: 98%

Cor e Forma: Powder

Peso molecular: 1253.51

Ref: TM-T1245

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate

Pureza: ≥95%

Peso molecular: 1253.51g/mol

Ref: 54-BUP17364

Colistin sulfate salt

CAS: 1264-72-8

Pureza: ≥ 19000U/mg (dried basis)

Cor e Forma: White to pale yellow, hygroscopic powder

Ref: 7W-GA9867

Colistin A Pentatrifluoroacetate (Polymyxin E1 Pentatrifluoroacetate)

CAS: 1264-72-8, 7722-44-3

Fórmula: C₅₃H₁₀₀N₁₆O₁₃·5C₂HF₃O₂

Peso molecular: 1169.48 5*114.02

Ref: 4Z-PC-321002

Colistin sulfate salt, Ph. Eur. grade

CAS: 1264-72-8

Pureza: ≤ 4.0%

Cor e Forma: White or almost white powder

Ref: 7W-GP4890

Colistin sulphate

CAS: 1264-72-8

Colistin sulphate

Fórmula: C₅₃H₁₀₀N₁₆O₁₃·H₂SO₄

Pureza: Sulphate: 17.2%; sulphated (Typical Value in Batch COA)

Cor e Forma: Solid

Peso molecular: 1,267.54g/mol

Ref: 54-BIC0118

Colistin sulfate

Produto Controlado

CAS: 1264-72-8

Fórmula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBCH₉₈N₁₆O₁₃·(H₂SO₄)

Cor e Forma: Neat

Peso molecular: 1169.46

Ref: 04-C11693500

Colistin sulfate 100 µg/mL in Water

Produto Controlado

CAS: 1264-72-8

Fórmula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBCH₉₈N₁₆O₁₃·(H₂SO₄)

Cor e Forma: Single Solution

Peso molecular: 1169.46

Ref: 04-A11693500WA-100

Colistin Sulfate (Mixture of A and B compound)

CAS: 1264-72-8

Ref: 4Z-PC-321001

Colistin Sulfate (Mixture of A and B compound)

Produto Controlado

CAS: 1264-72-8

Applications Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B.[α]D= -65° (c= 1, Water) LOD: 3% DAB= α,γ-diaminobutyric acidHeavy Metals: 20ppm Colistin A R= (+)-6-methyloctanoylArsenic Content: 2ppm/g Colistin B R= 6-methylheptanoylSulfate: 16-18%Biological Potency (dry basis): 19600U/mg
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Suzuki, T., et al.: J. Biochem., 54, 25 (1963), Barnett, M., et al.: Br. J. Pharmacol. Chemother., 23, 552 (1964), Littlewood, J, M., et al.: Respir. Med., 94, 632 (2000), Li, J., et al.: Int. J. Antimicrob. Ag., 25, 11 (2005),

Fórmula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBC₅₂H₉₈N₁₆O₁₃·(H₂SO₄)

Cor e Forma: White To Light Yellow

Peso molecular: 1169.46

Ref: TR-C641500

Colistin sulfate

CAS: 1264-72-8

Colistin is a narrow-spectrum antibiotic efficient mostly against gram-negative bacteria. Colistin interacts with the outer membrane of gram-negative bacteria and induces a transfer of divalent cations of calcium and magnesium from the negatively charged phosphate groups. This causes the disruption of the outer membrane and release of lipopolysaccharides. It is commonly used against Enterobacteriaceae and Aeromonas, and none-fermentative gram-negative bacteria as well as for carbapenem-resistant Acinetobacter strains.

Fórmula: C₅₃H₁₀₂N₁₆O₁₇S

Pureza: Min. 77 Area-%

Cor e Forma: White Powder

Peso molecular: 1,266.73 g/mol

Ref: 3D-AC20542

Colistin sulfate, Antibiotic for Culture Media Use Only

CAS: 1264-72-8

Antibacterial agent with the ability to permeate bacterial membranes and cause cell death. Colistin is a cationic peptide also known as polymyxin E. Colistin is effective in multidrug resistant Gram-positive bacteria such as P. aeruginosa, A. baumannii and K. pneumoniae.

Fórmula: C₅₃H₁₀₂N₁₆O₁₇S

Peso molecular: 1,266.73 g/mol

Ref: 3D-Q-200890

Colistin Sulphate (CLS)

CAS: 1264-72-8

Fórmula: (C₅₂H₉₈N₁₆O₁₃)·5(H₂SO₄)

Cor e Forma: White to pale yellow, Crystalline powder

Peso molecular: 2801.27

Ref: SR-51681