CAS 12650-69-0

Mupirocina

Descrição:

Mupirocina é um antibiótico tópico usado principalmente para o tratamento de infecções de pele causadas por certas bactérias, particularmente Staphylococcus aureus, incluindo cepas resistentes à meticilina (MRSA). É derivado da fermentação da bactéria Pseudomonas fluorescens. Mupirocina atua inibindo a síntese de proteínas bacterianas ao se ligar à isoleucil-tRNA sintetase, o que interrompe a incorporação de isoleucina nas proteínas, levando, em última instância, à morte celular bacteriana. A substância geralmente está disponível em forma de pomada ou creme e é aplicada diretamente na área afetada. Mupirocina é conhecido por sua baixa absorção sistêmica quando usado topicamente, tornando-o eficaz para infecções localizadas com risco mínimo de efeitos colaterais sistêmicos. Geralmente é bem tolerado, embora alguns pacientes possam experimentar irritação local ou reações alérgicas. Devido ao seu mecanismo de ação específico e eficácia contra cepas resistentes, Mupirocina é uma opção importante no manejo de infecções de pele e é frequentemente utilizado em ambientes ambulatoriais e hospitalares.

Fórmula: C₂₆H₄₄O₉

InChI: InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1

Chave InChI: InChIKey=MINDHVHHQZYEEK-HBBNESRFSA-N

SMILES: C([C@H]1[C@]([C@H]([C@H](C)O)C)(O1)[H])[C@@H]2[C@@H](O)[C@@H](O)[C@H](C/C(=C/C(OCCCCCCCCC(O)=O)=O)/C)OC2

Sinónimos:

• (E)-(2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-beta-methyl-2H-pyran-2-crotonic acid, ester with 9-hydroxynonanoic acid
• 8-Carboxyoctyl (E)-4-(2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxytetrahydro-2H-pyran-2-yl)-3-methylcrotonat
• 9-({(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-({(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoyl}oxy)nonanoic acid (non-preferred name)
• <span class="text-smallcaps">L</span>-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, (2E)-
• <span class="text-smallcaps">L</span>-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, [2E,8[2S,3S(1S,2S)]]-
• Bactoderm
• Bactroban
• Bactroban Ointment
• Brl 4910A
• Centany
• L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, (2E)-
• L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, [2E,8[2S,3S(1S,2S)]]-
• Mupirocin Neo-Sensitabs
• Mupirocin [USAN:INN:BAN]
• Mupirocina
• Mupirocina [Spanish]
• Mupirocine
• Mupirocine [French]
• Mupirocinum
• Mupirocinum [Latin]
• Mupricin
• Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))-
• Nonanoic acid, 9-[[(2Z)-3-methyl-1-oxo-4-[(2S,3R,4R,5S)-tetrahydro-3,4-dihydroxy-5-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]-2-oxiranyl]methyl]-2H-pyran-2-yl]-2-buten-1-yl]oxy]-
• Plasimine
• Pseudomonic acid
• Pseudomonic acid A
• Turixin
• Unii-D0Gx863Oa5

Mupirocin, 92%

CAS: 12650-69-0

Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococ

Fórmula: C₂₆H₄₄O₉

Pureza: 92%

Peso molecular: 500.63

Ref: 02-J66347

Mupirocin

CAS: 12650-69-0

Antibiotics nesoi

Fórmula: C₂₆H₄₄O₉

Cor e Forma: White Powder

Peso molecular: 500.29853

Ref: 45-1448901

L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, (2E)-

CAS: 12650-69-0

Fórmula: C₂₆H₄₄O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 500.6222

Ref: IN-DA000SV0

Mupirocin

CAS: 12650-69-0

Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.

Fórmula: C₂₆H₄₄O₉

Pureza: 97.37% - 97.46%

Cor e Forma: Solid

Peso molecular: 500.62

Ref: TM-T1465

Mupirocin

CAS: 12650-69-0

Mupirocin

Pureza: 920-1020μg/mg

Peso molecular: 500.63g/mol

Ref: 54-OR1029741

Mupirocin

CAS: 12650-69-0

Mupirocin

Pureza: ≥95%

Peso molecular: 500.62g/mol

Ref: 54-BUP15419

Mupirocin

CAS: 12650-69-0

Fórmula: C₂₆H₄₄O₉

Pureza: 920 - 1020 μg/mg (anhydrous)

Cor e Forma: White to off-white powder

Peso molecular: 500.63

Ref: 7W-GA2184

Mupirocin

CAS: 12650-69-0

Fórmula: C₂₆H₄₄O₉

Peso molecular: 500.63

Ref: 4Z-M-1816

Mupirocin

CAS: 12650-69-0

Fórmula: C₂₆H₄₄O₉

Pureza: >98.0%(T)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 500.63

Ref: 3B-M2955

Mupirocin

Produto Controlado

CAS: 12650-69-0

Fórmula: C₂₆H₄₄O₉

Cor e Forma: Neat

Peso molecular: 500.62

Ref: 86-MM1340.00

Mupirocin

Produto Controlado

CAS: 12650-69-0

Applications Mupirocin, is a major component of the pseudomonic acid, an antibiotic complex produced by Pseudomonas fluorescens NCIB 10586. Topical antibacterial.
References Hughes, J., et al.: J. Antibiot., 31, 330 (1978), Ward, A., et al.: Drugs, 32, 425 (1986), Casewell, M.W., et al.: J. Antimicrob. Chemother., 19, 1 (1987),

Fórmula: C₂₆H₄₄O₉

Cor e Forma: White To Off-White

Peso molecular: 500.62

Ref: TR-M794000

Mupirocin

CAS: 12650-69-0

Fórmula: C₂₆H₄₄O₉

Peso molecular: 500.63

Ref: ST-EA-CP-M50000

Mupirocin

CAS: 12650-69-0

Inhibitor of isoleucyl-tRNA synthetase; inhibitor of protein synthesis

Fórmula: C₂₆H₄₄O₉

Pureza: Min. 92 Area-%

Cor e Forma: White Powder

Peso molecular: 500.62 g/mol

Ref: 3D-AM26100