CAS 127-07-1

Hidroxiureia

Descrição:

Hidroxiureia, com o número CAS 127-07-1, é um composto químico que atua como agente antineoplásico, utilizado principalmente no tratamento de certos cânceres, como leucemia mieloide crônica e cânceres de cabeça e pescoço, bem como no manejo da doença falciforme. É um sólido cristalino branco que é solúvel em água e apresenta uma fórmula molecular de C₄H₈N₂O₂. Hidroxiureia funciona como um inibidor da ribonucleotídeo redutase, que interrompe a síntese de DNA ao impedir a conversão de ribonucleotídeos em desoxirribonucleotídeos, inibindo assim a proliferação celular. O composto também é conhecido por sua capacidade de aumentar os níveis de hemoglobina fetal em pacientes com doença falciforme, o que pode reduzir a frequência de crises dolorosas. Hidroxiureia é tipicamente administrado por via oral e pode ter efeitos colaterais, incluindo mielossupressão, distúrbios gastrointestinais e potenciais efeitos teratogênicos, exigindo monitoramento cuidadoso durante o tratamento. Seu mecanismo de ação e aplicações terapêuticas o tornam um agente significativo em oncologia e hematologia.

Fórmula: CH₄N₂O₂

InChI: InChI=1/CH4N2O2/c2-1(4)3-5/h3H2,(H2,2,4)

Chave InChI: InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N

SMILES: C(NO)(N)=O

Sinónimos:

• 1-Hydroxyurea
• Amino(Oxido-Λ5-Azanyl)Methanone
• Biosupressin
• Carbamohydroxamic acid
• Carbamohydroximic acid
• Carbamoyl oxime
• Carbamyl hydroxamate
• Cytodrox
• Droxia
• HU
• Hidrix
• Hidroxicarbamida
• Hydrea
• Hydreia
• Hydrixycarbamide
• Hydroxy Urea (D4)
• Hydroxy urea
• Hydroxycarbamid
• Hydroxycarbamide
• Hydroxycarbamine
• Hydroxylamine, N-(aminocarbonyl)-
• Hydroxylurea
• Hydura
• Hydurea
• Litaler
• Litalir
• Mylocel
• N-(aminocarbonyl)hydroxylamine
• N-Carbamoylhydroxylamine
• N-Hydroxyharnstoff
• N-Hydroxyurea
• Nci C04831
• Nsc 32065
• Onco-carbide
• Oxyrea
• Oxyurea
• Siklos
• Sk 22591
• Sq 1089
• Urea, N-hydroxy-
• Urea, hydroxy-
• Wr 83799
• Xromi
• hydroxyharnstoff
• carbamylhydroxamate
• Carbamoylhydroxylamine
• carbamohydroxyamicacid
• carbamohydroxamicacid
• hydroxy-ure
• HYDROXYUREA
• carbamoyloxime

Hydroxyurea

CAS: 127-07-1

Fórmula: CH₄N₂O₂

Pureza: >97.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 76.06

Ref: 3B-H0310

Hydroxyurea, 98%

CAS: 127-07-1

Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia

Fórmula: CH₄N₂O₂

Pureza: 98%

Cor e Forma: White to cream or yellow, Crystals or powder or crystalline powder

Peso molecular: 76.06

Ref: 02-A10831

HYDROXYCARBAMIDE CRS

CAS: 127-07-1

HYDROXYCARBAMIDE CRS

Fórmula: CH₄N₂O₂

Cor e Forma: Crystalline Powder. White. Powder.

Peso molecular: 76.0547

Ref: 41-Y0000119

Hydroxycarbamide

CAS: 127-07-1

Hydroxycarbamide

Fórmula: CH₄N₂O₂

Pureza: 99.6%

Cor e Forma: Off-White

Peso molecular: 76.02728

Ref: 47-197

Hydroxyurea

CAS: 127-07-1

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Fórmula: CH₄N₂O₂

Cor e Forma: White Off-White Powder

Peso molecular: 76.06 g/mol

Ref: 45-1332000

Urea, N-hydroxy-

CAS: 127-07-1

Fórmula: CH₄N₂O₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 76.0547

Ref: IN-DA000WIJ

Hydroxyurea

CAS: 127-07-1

Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

Fórmula: CH₄N₂O₂

Pureza: 99.85% - 99.92%

Cor e Forma: Solid

Peso molecular: 76.05

Ref: TM-T0676

Hydroxyurea

CAS: 127-07-1

Fórmula: CH₄N₂O₂

Pureza: 98.0 - 102.0 % (anhydrous basis)

Cor e Forma: White to off-white powder

Peso molecular: 76.06

Ref: 7W-GP0795

Hydroxyurea

CAS: 127-07-1

Hydroxyurea

Pureza: ≥98%

Peso molecular: 76.05g/mol

Ref: 54-BUP18378

Hydroxy Urea

CAS: 127-07-1

Fórmula: CH₄N₂O₂

Peso molecular: 76.06

Ref: 4Z-U-061

Hydroxyurea

CAS: 127-07-1

Hydroxyurea

Fórmula: CH₄N₂O₂

Pureza: 98%

Cor e Forma: white solid

Peso molecular: 76.05g/mol

Ref: 54-BIH0153

1-Hydroxyurea

CAS: 127-07-1

1-Hydroxyurea

Pureza: 98%

Peso molecular: 76.05g/mol

Ref: 54-OR9108

Hydroxy Urea

Produto Controlado

CAS: 127-07-1

Stability Hygroscopic
Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.
References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Fórmula: CH₄N₂O₂

Cor e Forma: White Solid

Peso molecular: 76.05

Ref: TR-H991000

Hydroxy Urea

CAS: 127-07-1

Fórmula: CH₄N₂O₂

Peso molecular: 76.06

Ref: ST-EA-CP-F32011

Hydroxyurea

CAS: 127-07-1

Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.

Fórmula: CH₄N₂O₂

Pureza: Min. 97.5 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 76.06 g/mol

Ref: 3D-FH09735

Hydroxyurea

CAS: 127-07-1

Fórmula: CH₄N₂O₂

Pureza: 98%

Cor e Forma: Solid, White crystalline powder

Peso molecular: 76.055

Ref: 10-F043351