CAS 127779-20-8

Saquinavir

Descrição:

Saquinavir é um medicamento antirretroviral utilizado principalmente no tratamento do HIV/AIDS. Pertence à classe dos inibidores da protease, que atuam inibindo a enzima protease, crucial para o processo de replicação viral. Saquinavir é caracterizado por sua relativamente baixa biodisponibilidade quando tomado por via oral, necessitando de sua administração em combinação com outros agentes antirretrovirais para aumentar sua eficácia. O composto é tipicamente apresentado como um sal mesilato, que melhora sua solubilidade e estabilidade. Quimicamente, Saquinavir apresenta uma estrutura complexa que inclui múltiplos centros quirais, contribuindo para sua atividade farmacológica. É conhecido por seus efeitos colaterais, que podem incluir distúrbios gastrointestinais e potenciais interações com outros medicamentos devido ao seu metabolismo via o sistema do citocromo P450. O desenvolvimento de Saquinavir marcou um avanço significativo no tratamento do HIV, e é frequentemente utilizado em terapia combinada para alcançar uma melhor supressão viral e melhorar os resultados dos pacientes.

Fórmula: C₃₈H₅₀N₆O₅

InChI: InChI=1/C38H50N6O5/c1-38(2,3)43-37(49)32-20-26-14-7-8-15-27(26)22-44(32)23-33(45)30(19-24-11-5-4-6-12-24)41-36(48)31(21-34(39)46)42-35(47)29-18-17-25-13-9-10-16-28(25)40-29/h4-6,9-13,16-18,26-27,30-33,45H,7-8,14-15,19-23H2,1-3H3,(H2,39,46)(H,41,48)(H,42,47)(H,43,49)/t26-,27+,30-,31-,32-,33+/m0/s1

Chave InChI: InChIKey=QWAXKHKRTORLEM-UGJKXSETSA-N

SMILES: C([C@H]([C@H](CC1=CC=CC=C1)NC([C@@H](NC(=O)C2=NC3=C(C=C2)C=CC=C3)CC(N)=O)=O)O)N4[C@H](C(NC(C)(C)C)=O)C[C@]5([C@@](C4)(CCCC5)[H])[H]

Sinónimos:

• Ro 31-8959
• Butanediamide, N1-[3-[3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, [3S-[2[1R*(R*),2S*],3α,4aβ,8aβ]]-
• (S)-N-[(αS)-α-[(1R)-2-[(3S,4aS,8aS)-3-(tert-Butylcarbamoyl)octahydro-2(1H)-isoquinolyl]-1-hydroxyethyl]phenethyl]-2-quinaldamidosuccinamide
• (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide
• Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-
• N~1~-{(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}-N~2~-(quinolin-2-ylcarbonyl)-L-aspartamide
• N~1~-{(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}-N~2~-(quinolin-2-ylcarbonyl)-L-aspartamide
• SAQUINAVIRMESYLATE(SUBJECTTOPATENTFREE)
• Ro 31-8959/000
• (3S)-N-tert-Butyl-2-[(2R,3S)-3-[N-(2-quinolinylcarbonyl)-3-carbamoylalanylamino]-2-hydroxy-4-phenylbutyl]-1,2,3,4,4aβ,5,6,7,8,8aβ-decahydroisoquinoline-3α-carboxamide
• (4aS,8aβ)-N-tert-Butyldecahydro-2-[(2R,3S)-2-hydroxy-4-phenyl-3-[[(2S)-3-carbamoyl-2-(2-quinolinylcarbonylamino)propanoyl]amino]butyl]isoquinoline-3α-carboxamide
• Ro-31-8959/003：Invirase
• SAGUINAVIR
• FLUNIXIN
• FLUNIXINE
• SAQUINAVIR
• n1-[(1s,2r)-3-[(3s,4as,8as)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1h)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-butanediamide
• (2S)-N-[(2S,3R)-4-[(3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE
• 2-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID
• Sch 52852
• Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-(9CI)

(2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide

CAS: 127779-20-8

Fórmula: C₃₈H₅₀N₆O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 670.8408

Ref: IN-DA019FSP

Saquinavir-d9

CAS: 127779-20-8

Fórmula: C₃₈H₄₁D₉N₆O₅

Pureza: ≥ 95%

Cor e Forma: White to off-white solid

Peso molecular: 679.90

Ref: 7W-GX7696

Saquinavir

CAS: 127779-20-8

Saquinavir

Pureza: ≥98%

Peso molecular: 670.84g/mol

Ref: 54-BUP14427

Saquinavir

CAS: 127779-20-8

Saquinavir (Ro 31-8959) is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.

Fórmula: C₃₈H₅₀N₆O₅

Pureza: 99.50% - >99.99%

Cor e Forma: Solid

Peso molecular: 670.84

Ref: TM-T7903

Saquinavir

Produto Controlado

CAS: 127779-20-8

Applications Saquinavir (CAS# 127779-20-8) is a useful research chemical compound.

Fórmula: C₃₈H₅₀N₆O₅

Cor e Forma: White To Off-White

Peso molecular: 670.84

Ref: TR-S212810

Saquinavir

CAS: 127779-20-8

Anti-viral; HIV protease inhibitor

Fórmula: C₃₈H₅₀N₆O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 670.84 g/mol

Ref: 3D-FS61498

Saquinavir - Bio-X ™

CAS: 127779-20-8

Saquinavir is a HIV protease inhibitor drug that is used with other antiretroviral drugs for the treatment of HIV-1. As this drug prevents HIV protease activity, it prevents the proteolysis of the Gag polyprotein and thus results in non-infectious virus particles.

Fórmula: C₃₈H₅₀N₆O₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 670.84 g/mol

Ref: 3D-BS164390

Saquinavir

CAS: 127779-20-8

Fórmula: C₃₈H₅₀N₆O₅

Pureza: 98%

Peso molecular: 670.855

Ref: 10-F547238