CAS 128-46-1

Dihidroestreptomicina

Descrição:

Dihidroestreptomicina é um antibiótico aminoglicosídeo derivado da bactéria Streptomyces griseus. É utilizado principalmente no tratamento de várias infecções bacterianas, particularmente aquelas causadas por Mycobacterium tuberculosis. O composto exibe um amplo espectro de atividade contra bactérias gram-negativas e algumas gram-positivas, inibindo a síntese de proteínas por meio da ligação à subunidade ribossomal 30S. Dihidroestreptomicina é caracterizado por sua relativamente baixa solubilidade em água, o que pode influenciar sua farmacocinética e biodisponibilidade. Geralmente é administrado por injeção devido à sua má absorção oral. A substância pode causar efeitos colaterais, incluindo nefrotoxicidade e ototoxicidade, que são preocupações comuns com os aminoglicosídeos. Sua estrutura química apresenta múltiplos grupos amino, contribuindo para sua basicidade e interação com ribossomos bacterianos. Dihidroestreptomicina é frequentemente utilizado em combinação com outros antibióticos para aumentar a eficácia terapêutica e reduzir o risco de desenvolvimento de resistência. Assim como todos os antibióticos, testes de suscetibilidade adequados são recomendados para garantir um tratamento eficaz.

Fórmula: C₂₁H₄₁N₇O₁₂

InChI: InChI=1S/C21H41N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1

Chave InChI: InChIKey=ASXBYYWOLISCLQ-HZYVHMACSA-N

SMILES: O([C@H]1[C@H](O[C@@H]2[C@@H](NC(=N)N)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]2O)O[C@@H](C)[C@@]1(CO)O)[C@H]3[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3

Sinónimos:

• 2,2'-[(1R,2R,3S,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
• 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl-5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-hydroxymethyl-beta-L-lyxo-pentanofuranoside
• 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl-5-deoxy-2-O-(2-deoxy-2-methylamino-α-<span class="text-smallcaps">L</smallcap>-glucopyranosyl)-3-hydroxymethyl-β-<smallcap>L</span>-lyxo-pentanofuranoside
• 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl-5-deoxy-2-O-(2-deoxy-2-methylamino-α-L-glucopyranosyl)-3-hydroxymethyl-β-L-lyxo-pentanofuranoside
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N,N′-bis(aminoiminomethyl)-
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N¹,N³-bis(aminoiminomethyl)-
• Abiocine
• D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N,N'-bis(aminoiminomethyl)-
• D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-
• DST
• Dhms
• Dhsm
• Dihidroestreptomicina
• Dihydrostreptomycine
• Dihydrostreptomycinum
• Diidrostreptomicina
• N'',N'''''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-L-glycero-hexopyranosyl]-3-C-(hydroxymethyl)-beta-D-glycero-pentofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (salt)
• N'',N'''''-[(1S,2S,3R,4S,5S,6R)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
• O-2-Deoxy-2-(methylamino)-α-<span class="text-smallcaps">L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</smallcap>-lyxofuranosyl-(1→4)-N¹,N³-bis(aminoiminomethyl)-<smallcap>D</span>-streptamine
• Streptamine, O-beta-D-mannopyranosyl-(1-4)-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-5-deoxy-O-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-diamidino-, D-
• Streptomycin, deoxydihydrohydroxy-
• Streptomycin, dihydro-
• Unii-P2I6R8W6Ua
• Vibriomycin

THIRD INTERNATIONAL STANDARD FOR DIHYDROSTREPTOMYCIN

CAS: 128-46-1

THIRD INTERNATIONAL STANDARD FOR DIHYDROSTREPTOMYCIN

Fórmula: C₂₁H₄₁N₇O₁₂

Peso molecular: 583.5899

Ref: 41-ISA42688

Dihydrostreptomycin 1000 µg/mL in Water

Produto Controlado

CAS: 128-46-1

Fórmula: C₂₁H₄₁N₇O₁₂

Cor e Forma: Single Solution

Peso molecular: 583.59

Ref: 04-A12635200WA-1000

Dihydrostreptomycin

CAS: 128-46-1

Dihydrostreptomycin is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating tuberculosis and bacterial infections in veterinary medicine.

Fórmula: C₂₁H₄₁N₇O₁₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 583.59 g/mol

Ref: 3D-AD29660

Dihydrostreptomycin

CAS: 128-46-1

Dihydrostreptomycin is an antibiotic.

Fórmula: C₂₁H₄₁N₇O₁₂

Pureza: 98%

Cor e Forma: Slightly Beige Solid

Peso molecular: 583.59

Ref: TM-T19806