CAS 128-62-1

1(3H)-Isobenzofuranona, 6,7-dimetoxi-3-[(5R)-5,6,7,8-tetrahidro-4-metoxi-6-metil-1,3-dioxolo[4,5-g]isoquinolin-5-il]-, (3S)-

Descrição:

1(3H)-Isobenzofuranona, 6,7-dimetoxi-3-[(5R)-5,6,7,8-tetrahidro-4-metoxi-6-metil-1,3-dioxolo[4,5-g]isoquinolin-5-il]-, (3S)-, conhecido pelo seu número CAS 128-62-1, é um composto orgânico complexo caracterizado por suas características estruturais únicas, incluindo um núcleo de isobenzofuranona fundido e um moiety de dioxoloisoquinolina. Este composto exibe uma variedade de grupos funcionais, incluindo grupos metóxi e dioxole, que contribuem à sua reatividade química e potencial atividade biológica. Normalmente é um sólido à temperatura ambiente e pode exibir solubilidade moderada em solventes orgânicos. A estereoquímica indicada pelas designações (5R) e (3S) sugere arranjos espaciais específicos de átomos, que podem influenciar as interações do composto em sistemas biológicos. Compostos desse tipo são frequentemente de interesse na química medicinal devido às suas potenciais propriedades farmacológicas, incluindo atividades anti-inflamatórias ou anticancerígenas. No entanto, estudos detalhados são necessários para elucidar completamente suas propriedades e aplicações em vários campos, incluindo produtos farmacêuticos e síntese orgânica.

Fórmula: C₂₂H₂₃NO₇

InChI: InChI=1/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18-;/m1./s1

Chave InChI: InChIKey=AKNNEGZIBPJZJG-MSOLQXFVSA-N

SMILES: O(C)C=1C=2[C@@](N(C)CCC2C=C3C1OCO3)([C@@]4(C=5C(C(=O)O4)=C(OC)C(OC)=CC5)[H])[H]

Sinónimos:

• (-)-Narcotine
• (-)-α-Narcotine
• (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
• 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[ 4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
• 1,3-Dioxolo[4,5-g]isoquinoline, 1(3H)-isobenzofuranone deriv.
• 1-α-Narcotine
• <span class="text-smallcaps">L</span>-α-Noscapine
• Capval
• Coscopin
• Coscotabs
• L-α-Noscapine
• Longactin
• Longatin
• Lyobex
• Methoxyhydrastine
• Narcompren
• Narcosine
• Narcotin
• Narcotussin
• Narkotin
• Nectadon
• Nicolane
• Nipaxon
• Noscapalin
• Noscapin
• Noscapina
• Noscapine
• Nsc 5366
• O-Methylarcotoline
• O-Methylnarcotoline
• Opian
• Opianin
• Opianine
• Terbenol
• Tusscapine
• Vadebex
• l-α-Narcotine
• 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
• (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
• (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
• 6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
• (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride
• 6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one
• tusseapine
• L-α-Narcotin
• l-alpha-2-methyl-8-methoxy-6,7-methylenedioxy-1-(6,7-dimethoxy-3-phthalidyl)-1
• Hederix (free base)
• Vadebe
• Key-Tusscapine
• Narcotine (7CI, 8CI)
• 5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4
• Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
• (S)-6,7-DIMETHOXY-3-((R)-4-METHOXY-6-METHYL-5,6,7,8-TETRAHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)-3H-ISOBENZOFURAN-1-ONE
• NOSCAPINE (NARCOTINE) NATURALLY OCCURRIN G O
• 1-alpha-Narcotine
• Detusso
• Noscapine (100 mg)
• Noscapine (Narcotine) base
• Noscapine (base and/or unspecified salts)
• Ecasil
• S(R*,S*)-6,7-DIMETHOXY-3-(5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]-ISOQUINOLIN-5-YL)-1(3H)-ISOBENZOFURANONE
• (S,R)-NOSCAPINE
• [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone
• ,2,3,4-tetrahydroisoquinaline
• Gnoscopine [dl-form]
• Terial
• 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1(3h)-isobenzofuranon
• dl-Narcotine [dl-form]
• 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (9CI)
• alpha-Narcotine
• nsc5366
• 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone, [S-(R*,S*)]
• Noscapine (500 mg)
• 5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4
• Noscapal
• L-ALPHA-NARCOTINE

Noscapine Hydrochloride

CAS: 128-62-1, 219533-73-0, 912-60-7

Fórmula: C₂₂H₂₃NO₇·HCl

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 449.88

Ref: 3B-N0963

Noscapine

CAS: 128-62-1

Cor e Forma: Neat

Ref: 61-FOR1232.00

Noscapine 1.0 mg/ml in Acetonitrile

CAS: 128-62-1

Cor e Forma: Single Solution

Ref: 61-AMP1232.00-11

NOSCAPINE CRS

CAS: 128-62-1

NOSCAPINE CRS

Fórmula: C₂₂H₂₃NO₇

Cor e Forma: Added Modified

Peso molecular: 413.4205

Ref: 41-N1300000

Noscapine

CAS: 128-62-1

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Fórmula: C₂₂H₂₃NO₇

Cor e Forma: White Powder

Peso molecular: 413.14745

Ref: 45-1474504

Noscapine

CAS: 128-62-1

Fórmula: C₂₂H₂₃NO₇

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 413.4205

Ref: IN-DA007O3K

Noscapine

CAS: 128-62-1

Fórmula: C₂₂H₂₃NO₇

Cor e Forma: White To Off-White Solid

Peso molecular: 413.43

Ref: 4Z-N-061012

Noscapine-13C-d3

CAS: 128-62-1

Fórmula: CC₂₁H₂₀D₃NO₇

Cor e Forma: White To Off-White Solid

Peso molecular: 417.44

Ref: 4Z-N-061001

Noscapine

CAS: 128-62-1

Cor e Forma: Neat

Ref: 86-MM1232.00

Noscapine

Produto Controlado

CAS: 128-62-1

Fórmula: C₂₂H₂₃NO₇

Cor e Forma: Neat

Peso molecular: 413.42

Ref: 04-C15652400

Noscapine

CAS: 128-62-1

Applications Antitussive.
References Tsunoda, N., et al.: Xenobiotica, 9, 181 (1979), Dhalstroem, B., et al.: Eur. J. Clin. Pharmacol., 22, 535 (1982), Al-Yahya, M.A., et al.: Anal. Profiles Drug Subs., 11, 407 (1982),

Fórmula: C₂₂H₂₃NO₇

Cor e Forma: White

Peso molecular: 413.42

Ref: TR-N882000

Noscapine base

CAS: 128-62-1

Noscapine base is a natural alkaloid compound, which is derived from the opium poppy, Papaver somniferum. This bioactive compound modulates the microtubule assembly in cells, impacting the dynamic instability of microtubules, which is crucial in mitosis and cell division. The resultant modulation disrupts microtubule function, thereby exerting a cytostatic effect that hampers the proliferation of malignant cells.

Fórmula: C₂₂H₂₃NO₇

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 413.43 g/mol

Ref: 3D-FN09246