CAS 128270-60-0

Bivalirudina

Descrição:

Bivalirudina é um peptídeo sintético que funciona como um inibidor direto da trombina, utilizado principalmente como anticoagulante em ambientes clínicos, particularmente durante intervenções coronárias percutâneas. Sua estrutura consiste em 20 aminoácidos e é derivada do peptídeo hirudina encontrado em sanguessugas. Bivalirudina exibe uma alta afinidade pela trombina, prevenindo efetivamente a conversão de fibrinogênio em fibrina, o que é crucial no processo de coagulação. A substância é administrada por injeção intravenosa e tem uma meia-vida relativamente curta, necessitando de monitoramento cuidadoso dos níveis de anticoagulação durante o tratamento. Bivalirudina é caracterizado por sua estabilidade na corrente sanguínea e sua capacidade de fornecer anticoagulação rápida com um perfil farmacocinético previsível. Muitas vezes é preferido em relação aos anticoagulantes tradicionais devido ao seu menor risco de induzir trombocitopenia e sua facilidade de uso em pacientes com função renal variável. No geral, Bivalirudina representa um avanço significativo na terapia anticoagulante, particularmente no manejo da síndrome coronária aguda.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

InChI: InChI=1/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1

Sinónimos:

• L-leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-
• D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine
• Bivalirudin,TFA
• Bivalirudin Trifluoroacetate

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a highly specific and reversible direct thrombin inhibitor.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 98.9%

Cor e Forma: White

Peso molecular: 2180.32

Ref: 01-4049766

Bivalirudin

CAS: 128270-60-0

Cardiovascular drugs, not elsewhere specified or included

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Cor e Forma: White Off-White Powder

Peso molecular: 2178.98581

Ref: 45-1076013

L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 2180.2853

Ref: IN-DA000XXZ

Bivalirudin

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Peso molecular: 2180.29

Ref: 7W-GP4765

Bivalirudin

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Cor e Forma: White To Off-White Solid

Peso molecular: 2180.32

Ref: 4Z-PB-122001

Bivalirudin Trifluoroacetate

CAS: 128270-60-0

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 2180.29

Ref: BP-BPPG010

Bivalirudin

CAS: 128270-60-0

Bivalirudin

Cor e Forma: Powder

Peso molecular: 2,180.29g/mol

Ref: 54-BITP1474

Bivalirudin

CAS: 128270-60-0

Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: 98.8% - >99.99%

Cor e Forma: White To Off-White Powder

Peso molecular: 2180.29

Ref: TM-T5519

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a synthetic cyclic peptide that binds to the ATP-binding cassette transporter and inhibits the activity of the proteolytic enzyme, angiotensin-converting enzyme (ACE). ACE inhibition prevents the conversion of angiotensin I to angiotensin II. Bivalirudin has been shown to be effective in reducing mortality in patients with acute coronary syndrome or undergoing percutaneous coronary intervention. It has also been shown to have pharmacokinetic properties that are similar to those of heparin. The drug has a low dose and is not associated with an increased risk of bleeding. Bivalirudin is an inhibitor and can cause drug interactions when combined with other drugs that are inhibitors or substrates for this type of transporter.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: Min. 95%

Peso molecular: 2,180.33 g/mol

Ref: 3D-BIV-3767-PI

Bivalirudin

CAS: 128270-60-0

Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.

Fórmula: C₉₈H₁₃₈N₂₄O₃₃

Pureza: Min. 95%

Cor e Forma: White Solid

Peso molecular: 2178.98581

Ref: 3D-FB29604

Bivalirudin 1-11 Fragment Trifluoroacetic Acid Salt

Produto Controlado

CAS: 128270-60-0

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Fórmula: C₄₃H₆₃N₁₅O₁₅·(C₂HF₃O₂)x

Cor e Forma: Neat

Peso molecular: 1030.0511402

Ref: TR-B591640