CAS 128545-09-5

N-[(9H-Fluoren-9-ilmetoxi)carbonil]-3-(trifenilmetil)-L-histidina

Descrição:

N-[(9H-Fluoren-9-ilmetoxi)carbonil]-3-(trifenilmetil)-L-histidina, comumente referido como Fmoc-His(Trt)-OH, é uma forma protegida do aminoácido histidina usada principalmente na síntese de peptídeos. Este composto apresenta um grupo protetor de fluorenilmetoxicarbonila (Fmoc), que é amplamente utilizado para a proteção temporária de grupos amino durante a síntese de peptídeos. O grupo triphenylmethyl (Trt) fornece proteção adicional para a cadeia lateral da histidina, aumentando a estabilidade e prevenindo reações indesejadas. A presença desses grupos protetores permite reações de desproteção e acoplamento seletivas, facilitando a montagem de peptídeos complexos. Fmoc-His(Trt)-OH é tipicamente um sólido branco a off-white e é solúvel em solventes orgânicos como dimetilformamida (DMF) e dimetilsulfóxido (DMSO), mas menos solúvel em água. Sua estabilidade sob condições padrão de acoplamento de peptídeos torna-o um intermediário valioso no campo da química orgânica e medicinal, particularmente no desenvolvimento de terapias baseadas em peptídeos.

Fórmula: C₄₀H₃₃N₃O₄

InChI: InChI=1/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-41-27-43(31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/p-1/t37-/m0/s1

Chave InChI: InChIKey=LCDUPKDPUSBXAY-QNGWXLTQSA-N

SMILES: C(N1C(C[C@H](NC(OCC2C=3C(C=4C2=CC=CC4)=CC=CC3)=O)C(O)=O)=CN=C1)(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

Sinónimos:

• (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(1-trityl-1H-imidazol-5-yl)propanoate
• <span class="text-smallcaps">L</span>-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-
• Fmoc-His(Trt)-OH
• Fmoc-L-His(Trt)-OH
• N(alpha)-fmoc-N(im)-trityl-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine
• N-Fmoc-N'-trityl-L-histidine
• N-[(9H-Fluoren-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-<span class="text-smallcaps">L</span>-histidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-tritylhistidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-trityl-L-histidine
• N-alpha-(9-fluorenylmethyloxycarbonyl)-N-im-trityl-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-
• N-ALPHA-FMOC--TRITYL-L-HISTIDINE
• FMOC-L-HIS(1-TRT)-OH
• N-[(9H-Fluoroen-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine USP/EP/BP
• Nalpha-fluorenylmethoxycarbonyl-im-trityl-L-histidine
• (S)-2-((((9H-Fluoren-3-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-5-yl)propanoic acid
• NALPHA-9-Fluorenylmethoxycarbonyl-NPI-trityl-L-histidine
• na-fmoc-im-trityl-L-histidine

L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-

CAS: 128545-09-5

Fórmula: C₄₀H₃₃N₃O₄

Peso molecular: 619.7077

Ref: IN-DA000Y76

Fmoc-His(Trt)-OH

CAS: 128545-09-5

Fmoc-His(Trt)-OH is a synthetic antimicrobial peptide that belongs to the class of acetylcholine. The peptide was found to inhibit the growth of a number of bacterial genera, including Pseudomonas, Acinetobacter and Burkholderia. The sequence of Fmoc-His(Trt)-OH is acetylated at the N-terminus and amidated at the C-terminus. This peptide has been found to have a broad spectrum of activity against drug resistant bacteria. It has also been shown to be active against mammalian cells in addition to bacterial cells, suggesting it may have therapeutic potential for humans as well as animals.

Fórmula: C₄₀H₃₃N₃O₄

Pureza: Min. 98.0 Area-%

Peso molecular: 619.73 g/mol

Ref: 3D-FLH-1740-PI