CAS 129-49-7

Maleato de metisergida

Descrição:

Maleato de metisergida é um composto sintético conhecido principalmente por seu uso no tratamento de enxaquecas e cefaleias em cluster. É um derivado do ácido lisérgico e atua como um antagonista do receptor de serotonina, particularmente nos locais dos receptores 5-HT2. A substância aparece como um pó cristalino branco a off-white e é tipicamente administrada na forma de comprimidos. Maleato de metisergida é caracterizado por sua relativamente baixa solubilidade em água, o que pode influenciar sua biodisponibilidade e farmacocinética. Tem uma meia-vida moderada, permitindo a dosagem uma ou duas vezes ao dia em ambientes clínicos. No entanto, o uso prolongado pode levar a efeitos colaterais, incluindo fibrose retroperitoneal e hipertensão pulmonar, exigindo monitoramento cuidadoso dos pacientes. Devido a esses potenciais efeitos adversos, seu uso se tornou menos comum e muitas vezes é considerado quando outros tratamentos falharam. Maleato de metisergida é classificado na categoria de alcaloides do ergot, que são conhecidos por suas propriedades vasoconstritoras.

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

InChI: InChI=1/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1

SMILES: CN1C2=C3C(C=4[C@@](CC3=C1)(N(C)C[C@H](C(N[C@@H](CC)CO)=O)C4)[H])=CC=C2.C(=C\C(O)=O)\C(O)=O

Sinónimos:

• (+)-N-[(1-Hydroxymethyl)propyl]-1-methyl-<span class="text-smallcaps">D</span>-lysergamide bimaleate
• (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
• (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide
• 1-Methyl-<span class="text-smallcaps">D</span>-lysergic acid butanolamide bimaleate
• Deseril-retard
• Desernil
• Desernil bimaleate
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, [8β(S)]-, (Z)-2-butenedioate (1:1) (salt)
• Ergoline-8β-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, maleate (1:1) (salt)
• Lysergamide, N-[1-(hydroxymethyl)propyl]-1-methyl-, maleate
• Methysergide Hydrogen Maleate
• Methysergide bimaleate
• NSC 186061

Methysergide Maleate

CAS: 129-49-7

Alkaloids of rye ergot and their derivatives; salts the

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Cor e Forma: Powder

Peso molecular: 469.22129

Ref: 45-1440003

Methysergide maleate salt

CAS: 129-49-7

Fórmula: C₂₅H₃₁N₃O₆

Pureza: ≥ 99.0% (anhydrous)

Cor e Forma: White to off-white crystalline powder

Peso molecular: 469.53

Ref: 7W-GP2886

Methysergide Maleate

Produto Controlado

CAS: 129-49-7

Stability Hygroscopic
Applications Methysergide Maleate acts as a serotonin antagonist with potential application antidepression medication. It is a 5-HT antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Masalov, I. et al.: J. Evol. Biochem. Phys., 48, 523 (2012); Fletcher, P. et al.: Psychopharm., 96, 236 (1988);

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Cor e Forma: Neat

Peso molecular: 469.53

Ref: TR-M329350

Methysergide maleate monohydrate

Produto Controlado

CAS: 129-49-7

Methylergide maleate monohydrate is a high-quality reagent that is useful as an intermediate for the synthesis of complex compounds. It is also a fine chemical that can be used in research and development. Methylergide maleate monohydrate has CAS No. 129-49-7, and it can be used to produce speciality chemicals or reaction components. It has a wide range of applications, such as being a versatile building block in organic synthesis and being a reaction component for the production of pharmaceuticals or agrochemicals.

Fórmula: C₂₅H₃₃N₃O₇

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 487.55 g/mol

Ref: 3D-FM39378

Methysergide maleate

Produto Controlado

CAS: 129-49-7

Methysergide is a drug that has been used in the treatment of chronic schizophrenia and other neurological disorders. It is an antagonist of glutamate, which inhibits the release of 5-HT (serotonin) and thereby reduces the concentration of this neurotransmitter in the brain. Methysergide has also been shown to inhibit the production of carcinoid syndrome and gamma-aminobutyric acid (GABA). Methysergide is related to estradiol benzoate, which is used to treat autoimmune diseases such as systemic lupus erythematosus (SLE). Symptoms may include fever, joint pain, photosensitivity, skin rash, muscle pain, and weight loss. The pharmacological treatment for these symptoms includes methotrexate or corticosteroids.

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Pureza: Min. 95%

Peso molecular: 469.53 g/mol

Ref: 3D-FM75152

Methysergide maleate

CAS: 129-49-7

Methysergide prevents migraines/cluster headaches; treats serotonin syndrome, carcinoid-induced diarrhea; risk of fibrosis limits use.

Fórmula: C₂₅H₃₁N₃O₆

Pureza: 98%

Cor e Forma: White To Off-White

Peso molecular: 469.54

Ref: TM-T21423

Methysergide maleate

CAS: 129-49-7

Methysergide maleate

Fórmula: C₂₁H₂₇N₃O₂

Pureza: 72.6%

Cor e Forma: Off White Solid

Peso molecular: 353.21033

Ref: 47-409