CAS 129-74-8

Cloridrato de buclizina

Descrição:

Cloridrato de buclizina é um antihistamínico usado principalmente para aliviar os sintomas de enjoo de movimento e tratar alergias. Pertence à classe de compostos de piperazina e exibe propriedades sedativas, tornando-o eficaz na redução de náuseas e vômitos associados a viagens. A substância é caracterizada por sua capacidade de bloquear os receptores de histamina H1, o que ajuda a mitigar reações alérgicas. Cloridrato de buclizina é tipicamente administrado por via oral e é conhecido por sua duração de ação relativamente longa. Em termos de propriedades físicas, é um pó cristalino branco a off-white que é solúvel em água e álcool. O composto tem uma fórmula molecular que reflete sua estrutura complexa, contribuindo para seus efeitos farmacológicos. Embora geralmente bem tolerado, pode causar efeitos colaterais como sonolência, boca seca e tontura. Assim como qualquer medicamento, é importante usar Cloridrato de buclizina sob supervisão médica para garantir segurança e eficácia, particularmente em indivíduos com condições de saúde preexistentes ou aqueles que estão tomando outros medicamentos.

Fórmula: C₂₈H₃₃ClN₂·2ClH

InChI: InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H

Chave InChI: InChIKey=SDBHDSZKNVDKNU-UHFFFAOYSA-N

SMILES: C(N1CCN(CC2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=C(Cl)C=C3)C4=CC=CC=C4.Cl

Sinónimos:

• 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
• 1-(4-Tert-Butylbenzyl)-4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazine Dihydrochloride
• 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine hydrochloride
• 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride
• 1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride
• Aphilan R
• Bucladin S
• Buclina
• Buclizine HCl
• Buclizine Hydrochloride
• Buclodin
• Histabutyzine hydrochloride
• Longifene
• NSC 25141
• Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2)
• Softran
• Ucb 4445
• Vibazine

Buclizine Hydrochloride

CAS: 129-74-8

Cor e Forma: Neat

Ref: 61-FOR0475.00

Buclizine hydrochloride impurity standard

CAS: 119-56-2, 129-74-8, 134-85-0, 303-26-4

Buclizine hydrochloride impurity standard

Cor e Forma: White

Ref: 47-440

Buclizine dihydrochloride

CAS: 129-74-8

Fórmula: C₂₈H₃₅Cl₃N₂

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 505.9499

Ref: IN-DA007NAA

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine dihydrochloride

Pureza: ≥98%

Peso molecular: 505.95g/mol

Ref: 54-BUP14697

Buclizine DiHCl

CAS: 129-74-8

Fórmula: C₂₈H₃₃ClN₂·2HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 433.04 2*36.46

Ref: 4Z-B-211

Buclizine Dihydrochloride

CAS: 129-74-8

Buclizine Dihydrochloride

Pureza: 99%

Peso molecular: 505.95g/mol

Ref: 54-OR1028300

Buclizine Hydrochloride

Produto Controlado

CAS: 129-74-8

Fórmula: C₂₈H₃₃ClN₂ClH

Cor e Forma: Neat

Peso molecular: 505.95

Ref: 86-MM0475.00

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and

Fórmula: C₂₈H₃₃ClN₂·2HCl

Pureza: 98.05%

Cor e Forma: Off-White Powder

Peso molecular: 505.95

Ref: TM-T6426

Buclizine-d8 DiHCl

CAS: 129-74-8

Fórmula: C₂₈H₂₅D₈ClN₂·2HCl

Peso molecular: 441.14 2 36.46

Ref: 4Z-B-212

Buclizine, Dihydrochloride

Produto Controlado

CAS: 129-74-8

Applications Used as an antiemetic.
References Jorgensen, P.B., et al.: Curr. Ther. Res., 16, 1276 (1974), Adam, E.I.: J. Int. Med. Res., 15, 71 (1987)

Fórmula: C₂₈H₃₃ClN₂·2ClH

Cor e Forma: White

Peso molecular: 505.95

Ref: TR-B689450

Buclizine Dihydrochloride

CAS: 129-74-8

Fórmula: C₂₈H₃₃ClN₂(HCl)

Peso molecular: 433.0 : 2(36.5)

Ref: ST-EA-CP-B30003

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine is a tricyclic antidepressant that inhibits the activity of dopamine receptors. It can be used to treat nausea and vomiting, which are symptoms of many chronic diseases, including cancer. Buclizine also has anti-infectious effects and can inhibit the growth of bacteria by preventing their ability to synthesize DNA. This drug is used as an antimicrobial agent for the treatment of infectious diseases such as syphilis and leprosy. The hypoglycemic effect of buclizine may be due to its ability to inhibit insulin release or to decrease the production of glucose by liver cells.

Fórmula: C₂₈H₃₅Cl₃N₂

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 505.95 g/mol

Ref: 3D-FB146989

Buclizine (piperazine-d8) Dihydrochloride

Produto Controlado

CAS: 129-74-8

Applications Buclizine (piperazine-d8) Dihydrochloride used as an antiemetic. It is the labelled version of B689450.
References Jorgensen, P.B., et al.: Curr. Ther. Res., 16, 1276 (1974); Adam, E.I.: J. Int. Med. Res., 15, 71 (1987)

Fórmula: C₂₈H₂₇D₈Cl₃N₂

Cor e Forma: Neat

Peso molecular: 441.077

Ref: TR-B689452