CAS 129203-60-7

iberiotoxina de buthus tamulus

Descrição:

A iberiotoxina, derivada do veneno do escorpião vermelho indiano (Buthus tamulus), é uma potente neurotoxina conhecida por sua inibição seletiva de certos canais de potássio, particularmente os canais de potássio dependentes de voltagem (Kv) em tecidos excitáveis. Essa característica a torna uma ferramenta valiosa em neurofarmacologia para estudar a função dos canais iônicos e os papéis fisiológicos dos canais de potássio em vários processos celulares. A iberiotoxina exibe uma alta afinidade pelo canal Kv1.3, que está implicado em respostas imunológicas e excitabilidade neuronal. A estrutura da toxina é caracterizada por uma cadeia polipeptídica que se dobra em uma conformação tridimensional específica, permitindo que interaja efetivamente com seus canais-alvo. Seu mecanismo de ação envolve a ligação ao canal e a prevenção do fluxo de íons de potássio, o que pode levar a uma despolarização prolongada de neurônios e células musculares. Devido aos seus efeitos potentes, a iberiotoxina também é de interesse em pesquisas relacionadas à dor, inflamação e potenciais aplicações terapêuticas, embora seu uso esteja principalmente confinado a ambientes laboratoriais devido à sua toxicidade.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

InChI: InChI=1/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(167(273)205-109(56-64-285-12)145(251)194-76-132(238)197-101(39-21-26-57-180)147(253)200-105(43-25-30-61-184)151(257)220-123-81-286-288-83-125(221-152(258)106(203-166(123)272)45-32-63-191-179(188)189)169(275)210-113(68-95-46-48-97(234)49-47-95)156(262)206-110(177(283)284)50-53-129(185)235)82-287-291-86-128(168(274)202-104(42-24-29-60-183)150(256)212-116(70-135(242)243)159(265)207-111)224-175(281)142(91(9)10)228-164(270)121(79-231)216-157(263)115(69-96-74-192-99-38-20-19-37-98(96)99)211-170(276)126-84-289-290-85-127(171(277)217-122(80-232)165(271)227-141(90(7)8)174(280)218-120(78-230)163(269)201-103(41-23-28-59-182)149(255)204-108(154(260)222-126)52-55-134(240)241)223-160(266)118(72-137(246)247)214-173(279)140(89(5)6)226-162(268)119(73-138(248)249)215-176(282)143(92(11)233)229-161(267)114(67-94-35-17-14-18-36-94)209-153(259)107-51-54-130(236)196-107/h13-20,33-38,46-49,74,87-92,100-128,139-143,192,230-234H,21-32,39-45,50-73,75-86,180-184H2,1-12H3,(H2,185,235)(H,193,250)(H,194,251)(H,195,252)(H,196,236)(H,197,238)(H,198,237)(H,199,264)(H,200,253)(H,201,269)(H,202,274)(H,203,272)(H,204,255)(H,205,273)(H,206,262)(H,207,265)(H,208,261)(H,209,259)(H,210,275)(H,211,276)(H,212,256)(H,213,278)(H,214,279)(H,215,282)(H,216,263)(H,217,277)(H,218,280)(H,219,254)(H,220,257)(H,221,258)(H,222,260)(H,223,266)(H,224,281)(H,225,239)(H,226,268)(H,227,271)(H,228,270)(H,229,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,283,284)(H4,186,187,190)(H4,188,189,191)

SMILES: CC(C)CC1C(=NC(Cc2ccccc2)C(=NCC(=NC(C(C)C)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NCC(=NC(CCCCN)C(=NC(CSSCC(C(=NC(CCCCN)C(=NC(CC(=O)O)C(=N1)O)O)O)N=C(C(C(C)C)N=C(C(CO)N=C(C(Cc1c[nH]c2ccccc12)N=C(C1CSSCC(C(=NC(CO)C(=NC(C(C)C)C(=NC(CO)C(=NC(CCCCN)C(=NC(CCC(=O)O)C(=N1)O)O)O)O)O)O)N=C(C(CC(=O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(Cc1ccccc1)N=C(C1CCC(=N1)O)O)O)O)O)O)O)O)O)O)O)C(=NC(CCSC)C(=NCC(=NC(CCCCN)C(=NC(CCCCN)C(=NC1CSSCC(C(=NC(Cc2ccc(cc2)O)C(=NC(CCC(=N)O)C(=O)O)O)O)N=C(C(CCCNC(=N)N)N=C1O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Sinónimos:

• Iberiotoxin, Buthus tamulus
• Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bonds between Cys7 and Cys28/Cys13 and Cys33/ Cys17 and Cys35)
• Iberiotoxin

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin (IbTx), from the venom of the scorpion Buthus tamulus, shows 68% sequence homology with charybdotoxin, another scorpion-derived peptidyl toxin. Although these two toxins both inhibit the high conductance Ca²⁺ activated K⁺ channel, they appear to bind at different sites on the channel and modulate channel activity by different mechanisms. Thus, iberiotoxin can be used to selectively study the function of the high conductance Ca²⁺ activated K⁺ channel.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: > 95%

Cor e Forma: Whitish Powder

Peso molecular: 4230.91

Ref: 01-4030755

2-(2-{[10-(2-{2-[2-(2-{[7,34-bis(4-aminobutyl)-25-benzyl-13-(3-carbamimidamidopropyl)-16,31-bis(carboxymethyl)-28-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-19-(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaco

CAS: 129203-60-7

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: ≥95%

Peso molecular: 4230.8479

Ref: IN-DA000YY4

Iberiotoxin

CAS: 129203-60-7

Selective blocker of the big conductance Ca2+-activated K+ channel.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 4230

Ref: TM-TP2014

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iberiotoxin on various ion channels and receptors.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: Min. 95%

Peso molecular: 4,230.8 g/mol

Ref: 3D-PIB-3813-PI

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin is a neurotoxin that is synthesized by the bacterium Clostridium botulinum. It inhibits the activity of a number of enzymes, including protein kinase C and cyclase, but has no effect on phosphatases. Iberiotoxin has been shown to be effective against models systems of bowel disease, such as colonic inflammation and ulceration. Iberiotoxin binds to specific neuronal receptors in the central nervous system, leading to inhibition of intracellular calcium levels, which may play an important role in the mechanisms of action for this toxin.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: Min. 95%

Peso molecular: 4,230.86 g/mol

Ref: 3D-FI110468

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iveriotoxin on various ion channels and receptors. This product is available as a 0.1mg vial.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: Min. 95%

Peso molecular: 4,230.8 g/mol

Ref: 3D-PIB-4235-S