CAS 130-26-7
:Clioquinol
Descrição:
Clioquinol, com o número CAS 130-26-7, é um composto orgânico que pertence à classe dos derivados de quinolina. É reconhecido principalmente por seu uso como agente antimicrobiano e tem sido empregado no tratamento de várias infecções gastrointestinais. Clioquinol exibe uma aparência cristalina amarela e é solúvel em solventes orgânicos, como etanol e clorofórmio, mas tem solubilidade limitada em água. O composto possui propriedades antibacterianas e antifúngicas, tornando-o eficaz contra uma variedade de patógenos. No entanto, seu uso tem sido associado a uma potencial neurotoxicidade, levando a restrições em suas aplicações clínicas. Clioquinol atua quelando íons metálicos, o que pode interromper o metabolismo microbiano. Sua estrutura química inclui um anel de quinolina e um grupo hidroxila, contribuindo para sua atividade biológica. Devido à sua importância histórica e às controvérsias em torno de sua segurança, Clioquinol continua sendo objeto de pesquisa, particularmente no contexto de doenças neurodegenerativas e seus potenciais papéis terapêuticos.
Fórmula:C9H5ClINO
InChI:InChI=1/C10H6ClIO/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,13H
Chave InChI:InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N
SMILES:OC=1C2=C(C(Cl)=CC1I)C=CC=N2
Sinónimos:- 5-Chloro-7-iodo-8-hydroxyquinoline
- 5-Chloro-7-iodo-8-oxyquinoline
- 5-Chloro-7-iodo-8-quinolinol
- 5-Chloro-7-iodoquinolin-8-ol
- 7-Iodo-5-chloro-8-hydroxyquinoline
- 7-Iodo-5-chloroxine
- 8-Hydroxy-7-iodo-5-chloroquinoline
- 8-Quinolinol, 5-chloro-7-iodo-
- Alchloquin
- Amebil
- Amoenol
- Bactol
- Barquinol
- Budoform
- Chinoform
- Chloroiodoquin
- Chloroiodoquine
- Chlorojodochin
- Cifoform
- Clioquinol
- Cliquinol
- Cort-Quin
- Dioquinol
- Dizenterol
- Eczecidin
- Emaform
- Entero-Vioform
- Enteroquinol
- Enteroseptol
- Enterozol
- Entrokin
- Hi-Eneterol
- Hi-Enterol
- Iodenterol
- Iodochlorhydroxyquin
- Iodochlorhydroxyquinol
- Iodochlorohydroxyquin
- Iodochlorohydroxyquinoline
- Iodochloroquine
- Iodochloroxine
- Iodochloroxyquinoline
- Iodoenterol
- Iodoxyquinoline
- Lekosept
- NSC 3531
- NSC 74938
- Nioform
- Quin-O-Creme
- Quinambicide
- Quinidochlor
- Quiniodochlor
- Quinoform
- Quinoform (antiseptic)
- Rheaform
- Rheaform Boluses
- Rometin
- Vioform
- Vioformio
- 5-Chlor-7-jod-8-hydroxy-chinolin
- AKOS B020410
- ala-quin
- 5-chloro-7-iodo-8-quinolino
- alchoquin
- chloroiodeoquim
- N-IODO-5-CHLORO-8-HYDROXYQUINOLINE
- Ver mais sinónimos
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17 produtos.
5-Chloro-8-hydroxy-7-iodoquinoline
CAS:Fórmula:C9H5ClINOPureza:>97.0%(T)Cor e Forma:Light yellow to Brown to Dark green powder to crystalPeso molecular:305.50CLIOQUINOL CRS
CAS:CLIOQUINOL CRSFórmula:C9H5ClINOCor e Forma:White. Whitish. Yellow. Dark. Powder.Peso molecular:305.4996Clioquinol
CAS:Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fusedFórmula:C9H5ClINOCor e Forma:PowderPeso molecular:304.91044Clioquinol
CAS:<p>Clioquinol: oral, lipophilic copper-binder; halogenated quinoline with antifungal, antiparasitic, and possible antitumor uses.</p>Fórmula:C9H5ClINOPureza:97.02%Cor e Forma:Brownish-Yellow Bulky Powder Decomposes At 178-179°C Used As A Topical Anti-InfectivePeso molecular:305.5Clioquinol
CAS:Fórmula:C9H5ClINOPureza:≥ 95.0%Cor e Forma:White to light-yellow, yellow or brown powder or crystalsPeso molecular:305.495-Chloro-8-hydroxy-7-iodoquinoline
CAS:5-Chloro-8-hydroxy-7-iodoquinolineFórmula:C9H5ClINOPureza:≥95%Cor e Forma: cream powderPeso molecular:305.50g/molClioquinol
CAS:Produto Controlado<p>Applications Clioquinol is used as an antiparasitic compound, known to induce apoptosis in leukemia and myeloma cells.<br>References Cao, B. et al.: J. Biol. Chem., 288, 34181 (2013); Chen, Z. et al.: Eur J. Med. Chem., 68, 454 (2013);<br></p>Fórmula:C9H5ClINOCor e Forma:NeatPeso molecular:305.505-Chloro-7-iodo-8-hydroxyquinoline
CAS:<p>5-Chloro-7-iodo-8-hydroxyquinoline is a metal chelate that has been shown to have pharmacological effects in experimental animals. It has antioxidative properties and can protect against oxidative injury. 5-Chloro-7-iodo-8-hydroxyquinoline was found to be toxic in various animal models, including the neuronal death and mitochondrial membrane potential. This toxicity may be due to its ability to inhibit the activity of DNA polymerase and protein synthesis. The compound also showed significant cytotoxicity at low concentrations, but had no significant cytotoxicity at higher concentrations. 5-Chloro-7-iodo-8-hydroxyquinoline is similar in structure to clioquinol, which has been shown to have neurotoxic effects in humans.</p>Fórmula:C9H5ClINOPureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:305.5 g/molClioquinol - Bio-X ™
CAS:<p>Clioquinol is an antifungal drug and antiprotozoal drug that has been shown to inhibit the activity of protein kinase-3 and to promote apoptosis. This compound has also been found to improve iron homeostasis, which may be due to its ability to counteract the effects of oxidative stress on the mitochondria. Additionally, it has been shown to have anti-fungal properties against opportunistic fungal pathogens such as Candida albicans. Clioquinol is extracted from a plant called "Clioquinia rosea" and is produced by a chemical reaction with 2-chloroethanol.</p>Fórmula:C9H5ClINOPureza:Min. 95%Cor e Forma:PowderPeso molecular:305.5 g/mol5-Chloro-7-Iodo-8-Quinolinol (Clioquinol, Iodochlorohydroxyquinoline) ExiPlus, Multi-Compendial, 97-103%
CAS:Fórmula:C9H5ClINOPureza:97.0-103.0%Cor e Forma:White to Light Yellow to Light Beige, Powder or Crystals, ClearPeso molecular:305.5
