CAS 131602-53-4

fragmento de proteína beta-amiloide 25-35

Descrição:

O fragmento da proteína beta-amiloide 25-35 (frequentemente referido como Aβ25-35) é um peptídeo derivado da proteína precursora de amiloide (APP) e é significativo no estudo da doença de Alzheimer. Este fragmento consiste em 11 aminoácidos e é conhecido por seu papel na formação de placas amiloides, que são características da patologia de Alzheimer. Aβ25-35 é particularmente notável por suas propriedades neurotóxicas, pois pode induzir estresse oxidativo e promover a morte celular neuronal. O peptídeo é frequentemente utilizado em pesquisas para modelar os efeitos da beta-amiloide em processos neurodegenerativos. Sua estrutura permite a agregação, levando à formação de fibrilas que podem interromper a função celular. Além disso, Aβ25-35 tem sido implicado na modulação da atividade sináptica e pode influenciar funções cognitivas. Compreender as características e o comportamento deste fragmento é crucial para desenvolver estratégias terapêuticas destinadas a mitigar os efeitos da beta-amiloide na doença de Alzheimer e em distúrbios relacionados.

Fórmula: C₄₅H₈₁N₁₃O₁₄S

InChI: InChI=1/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CC(C)C)C(=N[C@@H](CCSC)C(=O)O)O)O)O)N=C([C@H]([C@@H](C)CC)N=C([C@H](C)N=C(CN=C([C@H](CCCCN)N=C([C@H](CC(=N)O)N=C([C@H](CO)N=C(CN)O)O)O)O)O)O)O

Sinónimos:

• Amyloid Beta-Protein (Human, 25-35) Trifluoroacetate
• Beta-Amyloid(25-35)
• Abeta 25-35

Amyloid β (25-35)

CAS: 131602-53-4

For cellular and molecular biology applications

Cor e Forma: Powder, White to off-white

Ref: 02-J66808

Amyloid β-Protein (25-35)

CAS: 131602-53-4

The biologically active domain of the amyloid β-protein for neurotrophic and neurotoxic effects is located in the β (25-35) sequence GSNKGAIIGLM, which is homologous to a region in peptides of the tachykinin family.

Fórmula: C₄₅H₈₁N₁₃O₁₄S

Pureza: 97.0%

Cor e Forma: White Powder

Peso molecular: 1060.28

Ref: 01-4030205

β-Amyloid (25-35)

CAS: 131602-53-4

β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.

Fórmula: C₄₅H₈₁N₁₃O₁₄S

Pureza: 97.91%

Cor e Forma: Solid

Peso molecular: 1060.27

Ref: TM-T14284

Amyloid β Protein fragment 25-35

CAS: 131602-53-4

Amyloid β Protein fragment 25-35

Pureza: ≥97%

Peso molecular: 1,060.27g/mol

Ref: 54-BIBA1010

β-Amyloid (25-35)

CAS: 131602-53-4

β-Amyloid (25-35)

Pureza: ≥95%

Peso molecular: 1060.27g/mol

Ref: 54-BUP01506

Amyloid Beta-Protein (Human, 25-35)

CAS: 131602-53-4

Amyloid beta-Protein (Human, 25-35) is the shortest amyloid fragment that forms β-sheet fibrils, while retaining toxicity, and may also induce the aggregation of N-tau protein and N-tau peptide 1/2R. Consequently this peptide may play a role in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder that affects memory and cognitive function.
This product is available as a trifluoroacetate salt and as a 0.5mg vial.

Fórmula: C₄₅H₈₁N₁₃O₁₄S

Pureza: Min. 95%

Peso molecular: 1,060.3 g/mol

Ref: 3D-PAM-4309-V

Amyloid beta-Protein (25-35) trifluoroacetate salt

CAS: 131602-53-4

Amyloid beta-protein (Aβ) is a protein that is a major component of amyloid plaques in the brains of people with Alzheimer's disease. Aβ-Protein (25-35) trifluoroacetate salt, also known as Aβ(25-35), is an amyloid beta protein fragment that has been shown to inhibit neuronal death and increase antioxidative properties in human serum. It has been shown to have anti-apoptotic effects by inhibiting the activation of caspases and the release of cytochrome C from mitochondria. This drug may have physiological effects on the central nervous system due to its ability to induce apoptosis through mitochondrial membrane depolarization and cytosolic calcium levels. It has been shown to be active against Chinese herb Pueraria lobata and cell lysis, as well as granule neurons in culture. It may also stimulate phosphorylation of p38mapk and induce logarithmic growth

Fórmula: C₄₅H₈₁N₁₃O₁₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,060.27 g/mol

Ref: 3D-FA108377

AMYLOID β-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

CAS: 131602-53-4

Fórmula: C₄₅H₈₁N₁₃O₁₄S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 1060.268340000001

Ref: IN-DA009ATE