CAS 133407-82-6

N-[(Fenilmetoxi)carbonil]-L-leucil-N-[(1S)-1-formil-3-metilbutil]-L-leucinamida

Descrição:

N-[(Fenilmetoxi)carbonil]-L-leucil-N-[(1S)-1-formil-3-metilbutil]-L-leucinamida, com o número CAS 133407-82-6, é um composto sintético que pertence à classe de peptídeos e derivados de peptídeos. Esta substância apresenta uma estrutura complexa caracterizada pela presença de dois resíduos de aminoácidos de leucina, que contribuem para suas propriedades hidrofóbicas e potencial atividade biológica. O grupo fenilmetoxicarbonila melhora sua estabilidade e solubilidade, enquanto o grupo formilo-3-metilbutilo pode influenciar sua interação com alvos biológicos. O composto provavelmente exibirá características conformacionais específicas devido à presença de centros quirais, o que pode afetar suas propriedades farmacológicas. Como um derivado de peptídeo, pode ter aplicações em química medicinal, particularmente no desenvolvimento de terapias direcionadas a vias biológicas específicas. Sua síntese e caracterização normalmente envolveriam técnicas padrão de acoplamento de peptídeos, e sua atividade poderia ser avaliada através de vários ensaios bioquímicos. No geral, este composto representa uma área fascinante de estudo dentro da química de peptídeos e do design de fármacos.

Fórmula: C₂₆H₄₁N₃O₅

InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

Chave InChI: InChIKey=TZYWCYJVHRLUCT-VABKMULXSA-N

SMILES: [C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)(C(N[C@@H](CC(C)C)C=O)=O)CC(C)C

Sinónimos:

• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-leucyl-N-(1-formyl-3-methylbutyl)-, (S)-
• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-
• Calpain Inhibitor IV
• Calpain inhibitor IV-2
• Mg-132
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-<smallcap>L</span>-leucinamide
• N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide
• N-[(benzyloxy)carbonyl]leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]leucinamide
• Z-Leu-Leu-Leu-aldehyde
• N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
• L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(1-formyl-3-methylbutyl)-, (S)-

MG-132

CAS: 133407-82-6

Fórmula: C₂₆H₄₁N₃O₅

Pureza: >95.0%(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 475.63

Ref: 3B-M3244

MG 132

CAS: 133407-82-6

Inhibitor of calpain proteases

Fórmula: C₂₆H₄₁N₃O₅

Cor e Forma: Crystalline solid

Peso molecular: 475.63

Ref: 02-J63250

MG 132

CAS: 133407-82-6

Z-LLL-CHO (MG132) was shown to initiate neurite outgrowth in PC12 cells with an optimal concentration of 20 nM and to be a very strong inhibitor of 20S proteasome and of calpain.

Fórmula: C₂₆H₄₁N₃O₅

Pureza: 92.5%

Cor e Forma: White

Peso molecular: 475.63

Ref: 01-4027888

L-​Leucinamide, N-​[(phenylmethoxy)​carbonyl]​-​L-​leucyl-​N-​[(1S)​-​1-​formyl-​3-​methylbutyl]​-

CAS: 133407-82-6

Fórmula: C₂₆H₄₁N₃O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 475.6208

Ref: IN-DA0072SK

Calpain inhibitor IV

CAS: 133407-82-6

Calpain inhibitor IV

Fórmula: C₂₆H₄₁N₃O₅

Pureza: By hplc: 99.17% (Typical Value in Batch COA)

Cor e Forma: white to off-white solid

Peso molecular: 475.62g/mol

Ref: 54-BIC3742

MG-132

CAS: 133407-82-6

MG-132

Pureza: ≥95%

Peso molecular: 475.62g/mol

Ref: 54-BUP17157

Z-Leu-Leu-Leu-al

CAS: 133407-82-6

Fórmula: C₂₆H₄₁N₃O₅

Pureza: ≥ 97.0%

Cor e Forma: White to off-white powder or solid

Peso molecular: 475.63

Ref: 7W-GK3641

MG-132

CAS: 133407-82-6

MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!

Fórmula: C₂₆H₄₁N₃O₅

Pureza: 95% - 99.99%

Cor e Forma: White To Off-White Powder

Peso molecular: 475.62

Ref: TM-T2154

MG 132

CAS: 133407-82-6

Stability Hygroscopic
Applications MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
References Lee, D., et al.: Trends in Cell Biol., 8, 397 (1998); Tsubuki, S., et al.: J. Biochem., 119., 572 (1996); Grimm, L., et al.: EMBO J., 15, 3835 (1996)

Fórmula: C₂₆H₄₁N₃O₅

Cor e Forma: Neat

Peso molecular: 475.62

Ref: TR-M340900

Z-Leu-Leu-Leu-H (aldehyde)

CAS: 133407-82-6

Z-Leu-Leu-Leu-H (aldehyde) is an inhibitor that binds to a receptor and prevents the binding of a ligand. This competitive inhibition is reversible and can be used as a research tool to study protein interactions. The high purity of this product makes it ideal for use in pharmacology, cell biology, and life science research.

Fórmula: C₂₆H₄₁N₃O₅

Pureza: Min. 95%

Peso molecular: 475.62 g/mol

Ref: 3D-IZL-3175-V

Abz-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Gln-EDDnp

CAS: 133407-82-6

Abz-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Gln (EDDNP) is a novel and potent inhibitor of the polymerase chain reaction (PCR). It has been shown to inhibit the activity of DNA polymerases, which are key enzymes in DNA replication. EDDNP binds to the active site of the enzyme and blocks access to the DNA template. In addition, this compound inhibits mitochondrial membrane potential, as well as transcriptional regulation and detoxification enzymes. This compound has also been shown to be effective in vivo in mouse models.

Fórmula: C₆₁H₉₁N₂₁O₁₉S₂

Pureza: Min. 95%

Peso molecular: 1,486.66 g/mol

Ref: 3D-SFQ-3916-PI

MG 132

CAS: 133407-82-6

MG 132 is a modified tripeptide that acts as proteasomal inhibitor. In 2006, MG 132 has been experimentally tested in in vitro cell-based and in vivo models for to assess its use in the medical treatment of Parkinson's disease.

Fórmula: C₂₆H₄₁N₃O₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 475.30462

Ref: 3D-FM29307