CAS 13345-50-1

PGA2

Descrição:

PGA2, ou Prostaglandina A2, é um composto que ocorre naturalmente e pertence à classe das prostaglandinas, que são compostos lipídicos derivados de ácidos graxos. Desempenha um papel significativo em vários processos fisiológicos, incluindo inflamação, regulação do fluxo sanguíneo e modulação das respostas imunológicas. PGA2 é caracterizado por sua capacidade de interagir com receptores específicos no corpo, influenciando atividades celulares e vias de sinalização. Normalmente é um líquido incolor a amarelo pálido e é sensível à luz e ao calor, o que pode afetar sua estabilidade. O composto é solúvel em solventes orgânicos, mas tem solubilidade limitada em água. Devido à sua atividade biológica, PGA2 é de interesse na pesquisa farmacológica, particularmente no contexto da saúde cardiovascular e doenças inflamatórias. No entanto, o manuseio e o uso requerem cautela devido aos seus potentes efeitos biológicos. Assim como muitas prostaglandinas, sua síntese e degradação são rigidamente reguladas dentro dos sistemas biológicos, destacando sua importância na manutenção da homeostase.

Fórmula: C₂₀H₃₀O₄

InChI: InChI=1/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1

Chave InChI: InChIKey=MYHXHCUNDDAEOZ-FOSBLDSVSA-N

SMILES: C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)C=CC1=O

Sinónimos:

• (+)-Prostaglandin A₂
• (15S)-PGA₂
• (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
• 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostatrienoic acid
• 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostenoic acid
• 15(S)-Prostaglandin A₂
• 15-Hydroxy-9-Oxoprosta-5,10,13-Trien-1-Oic Acid
• 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienecarboxylic acid
• 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienoic acid
• 5,6-cis-PGA₂
• 5-Heptenoic acid, 7-[2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl]-
• Medullin
• NSC 165561
• PGA₂
• Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-
• Prostaglandin A2 solution
• Prostaglandin A2
• (5Z)-7-[(1R,2S)-2-[(1E,3S)-3-Hydroxy-1-octenyl]-5-oxo-3-cyclopenten-1-yl]-5-heptenoic acid
• pga(sup2)
• 7-(2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl)-5-heptenoicaci
• (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid, PGA2
• 5,6-cis-pga(sup2)
• prostaglandina(sup2)
• (+)-prostaglandina(sup2)
• 9-OXO-15S-HYDROXY-PROSTA-5Z,10,13E-TRIEN-1-OIC ACID
• prostaglandin A(2) solution
• (155)-pga2
• PGA2 (Prostaglandin A2)
• PGA2
• 15-hydroxy-9-oxo-,(5z,13e,15s)-prosta-10-13-trien-1-oicacid
• Prostaglandin A2 solution,(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid, PGA2
• (5Z,13E,15S)-15-Hydroxy-9-oxo-5,10,13-prostatrien-1-oic acid
• PROSTAGLANDINS A2

Prosta-5,10,13-trien-1-oicacid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-

CAS: 13345-50-1

Fórmula: C₂₀H₃₀O₄

Pureza: 98%

Cor e Forma: Liquid

Peso molecular: 334.4498

Ref: IN-DA0080H8

Dinoprostone EP Impurity D (Prostaglandin A2)

CAS: 13345-50-1

Fórmula: C₂₀H₃₀O₄

Peso molecular: 334.46

Ref: 4Z-D-250002

Prostaglandin A2

Produto Controlado

CAS: 13345-50-1

Applications Prostaglandin A2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. Prostaglandin A2 is generally not present in mammals. Prostaglandin A2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity. Prostaglandin A2 has also been shown to act as a vasodilator with natriuretic properties.
References Stenson, W., et al.: J. Immunol., 124, 2100 (1980), Bray, M., et al.: Prostaglandins, 22, 213 (1981), Funk, C., et al.: Science, 294, 1871 (2001), Newman, J., et al.: J. Lipid Res., 43, 1563 (2002), Blaho, V., et al.: J. Biol. Chem., 284, 21599 (2009),

Fórmula: C₂₀H₃₀O₄

Cor e Forma: Neat

Peso molecular: 334.45

Ref: TR-P838550

Prostaglandin A6

CAS: 13345-50-1

Prostaglandin A6 is a lipid mediator that is involved in the regulation of many physiological and pathological processes. It has been shown to inhibit the activity of ion channels, increase the permeability of cell membranes, and activate G protein-coupled receptors. Prostaglandin A6 has been extensively used as an inhibitor in research tools for studying cell biology, peptides, pharmacology, ligand binding, and protein interactions. In addition, prostaglandin A6 is a potent activator of G protein-coupled receptors that are found in cardiovascular tissues. This compound also inhibits platelet aggregation and activates vasodilatory pathways.

Fórmula: C₂₀H₃₀O₄

Pureza: Min. 95%

Peso molecular: 334.4 g/mol

Ref: 3D-BP180569

Dinoprostone EP Impurity D

CAS: 13345-50-1

Fórmula: C₂₀H₃₀O₄

Peso molecular: 334.5

Ref: ST-EA-CP-D117004

Prostaglandin A2

CAS: 13345-50-1

PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]

Fórmula: C₂₀H₃₀O₄

Cor e Forma: Solid

Peso molecular: 334.45

Ref: TM-T36542