CAS 13434-13-4

Actinonina

Descrição:

Actinonina, com o número CAS 13434-13-4, é um composto que ocorre naturalmente e é conhecido principalmente por seu papel como antibiótico. É derivado da bactéria *Streptomyces griseus* e apresenta notáveis propriedades antibacterianas, particularmente contra certas cepas de bactérias. Actinonina atua inibindo a enzima aminopeptidase N, que está envolvida no metabolismo de proteínas, interrompendo assim o crescimento e a proliferação bacteriana. O composto é caracterizado por sua estrutura molecular específica, que inclui uma estrutura bicíclica única que contribui para sua atividade biológica. Actinonina tem sido estudado por suas potenciais aplicações terapêuticas, particularmente no tratamento de infecções causadas por cepas bacterianas resistentes. Além disso, tem sido investigado por seus efeitos em vários sistemas biológicos, tornando-se um assunto de interesse em química medicinal e farmacologia. Seu perfil de segurança e eficácia em ambientes clínicos continua sendo áreas de pesquisa, enquanto os cientistas exploram seus possíveis usos na medicina moderna.

Fórmula: C₁₉H₃₅N₃O₅

InChI: InChI=1/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1

Chave InChI: InChIKey=XJLATMLVMSFZBN-VYDXJSESSA-N

SMILES: C([C@@H](NC([C@@H](CC(NO)=O)CCCCC)=O)[C@H](C)C)(=O)N1[C@H](CO)CCC1

Sinónimos:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide
• (2R)-N~4~-hydroxy-N~1~-{(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide
• 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]-Carbonyl]-2-Methylpropyl]-Carbamoyl]-Octonohydroxamic Acid
• 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]Carbonyl]-2-Methyl-Propyl]Carbamoyl]Octanohydroxamic Acid
• Actinonine
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer
• Cona 57
• Hylpropyl)Carbamoyl)-
• N4-Hydroxy-N1-[(1S)-1[[(2S)-2-(hydroxymethyl)-1-pyrroldinyl]carbonyl]-2-methylpropyl]-2-pentyl-,(2R)-(9CI)
• N~4~-hydroxy-N~1~-{1-[2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide
• Octanohydroxamic acid, 3-[[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]-
• Octanohydroxamicacid,3-((1-((2-(Hydroxymethyl)-1-Pyrrolidinyl)Carbonyl)-2-Met
• Ro 06-1467
• (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide
• Butanediamide, N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
• (-)-ACTINONIN
• Butanediamide, N4-hydroxy-N1-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer
• (2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxo-butan-2-yl]-2-pentyl-butanediamide
• Actininin
• Butanediamide, N4-hydroxy-N1-(1S)-1-(2S)-2-(hydroxymethyl)-1-pyrrolidinylcarbonyl-2-methylpropyl-2-pentyl-, (2R)-
• (2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
• (R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide
• (2R)-2-[2-(hydroxyamino)-2-keto-ethyl]-N-[(1S)-2-methyl-1-[(2S)-2-methylolpyrrolidine-1-carbonyl]propyl]enanthamide
• (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]carbonyl]-2-Methylpropyl]-2-pentyl-butanediaMide

Actinonin

CAS: 13434-13-4

Fórmula: C₁₉H₃₅N₃O₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 385.4983

Ref: IN-DA00800W

(R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide

CAS: 13434-13-4

(R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide

Pureza: 95%

Peso molecular: 385.51g/mol

Ref: 54-OR1073265

Actinonin

CAS: 13434-13-4

Fórmula: C₁₉H₃₅N₃O₅

Pureza: ≥ 97.0%

Cor e Forma: White to light yellow powder

Peso molecular: 385.50

Ref: 7W-GA8851

Actinonin

CAS: 13434-13-4

Actinonin is a natural product with antimicrobial activity. It inhibits the growth of bacteria by binding to their ribosomes and inhibiting protein synthesis. Actinonin has been shown to inhibit the growth of gram-positive species such as Streptococcus pyogenes, group A beta-hemolytic streptococci, and Enterococcus faecalis. Actinonin also inhibits a number of enzymes including target enzymes for antimicrobial agents such as penicillin and erythromycin. Actinonin has been shown to be a potential biomarker for bowel disease in humans by its ability to bind to mitochondria in cells from patients with inflammatory bowel disease. This compound binds to basic proteins, which are found in high concentrations in the cell nucleus of organisms including humans.

Fórmula: C₁₉H₃₅N₃O₅

Pureza: Min. 95%

Peso molecular: 385.51 g/mol

Ref: 3D-IAC-4157-PI

(-)-Actinonin

Produto Controlado

CAS: 13434-13-4

Applications (-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
References Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),

Fórmula: C₁₉H₃₅N₃O₅

Cor e Forma: Neat

Peso molecular: 385.50

Ref: TR-A192000

(-)-Actinonin

CAS: 13434-13-4

Antibiotic peptide; inhibitor of aminopeptidase M and leucine aminopeptidase

Fórmula: C₁₉H₃₅N₃O₅

Pureza: Min. 95%

Peso molecular: 385.5 g/mol

Ref: 3D-FA17212

Actinonin

CAS: 13434-13-4

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].

Fórmula: C₁₉H₃₅N₃O₅

Cor e Forma: Solid

Peso molecular: 385.5

Ref: TM-T14121