CAS 134381-21-8

Epoxomicina

Descrição:

Epoxomicina é um inibidor potente e seletivo do proteassoma, conhecido principalmente por seu papel em pesquisas relacionadas ao câncer e doenças neurodegenerativas. É um produto natural derivado da fermentação da bactéria *Streptomyces*. O composto apresenta um grupo funcional epóxido único, que contribui ao seu mecanismo de ação ao se ligar covalentemente ao sítio ativo do proteassoma, inibindo assim sua função. Essa inibição leva ao acúmulo de proteínas reguladoras e apoptose em células cancerosas, tornando-se uma ferramenta valiosa na pesquisa do câncer. Epoxomicina também foi estudado por seus potenciais efeitos neuroprotetores, pois pode influenciar a degradação de proteínas mal dobradas associadas a distúrbios neurodegenerativos. Em termos de propriedades físicas, Epoxomicina é tipicamente caracterizado por seu estado sólido à temperatura ambiente e é solúvel em solventes orgânicos. Seu uso em ambientes laboratoriais requer manuseio cuidadoso devido à sua atividade biológica e potencial toxicidade. No geral, Epoxomicina serve como um composto importante no estudo da função do proteassoma e suas implicações em várias doenças.

Fórmula: C₂₈H₅₀N₄O₇

InChI: InChI=1/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-26(37)22(18(7)33)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,29,33H,11-14H2,1-10H3,(H,30,38)(H,31,36,37)/t16-,17-,18+,20?,21-,22-,23-,28+/m0/s1

Chave InChI: InChIKey=DOGIDQKFVLKMLQ-JTHVHQAWSA-N

SMILES: C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N(C(C)=O)C)[C@H](CC)C)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CC(C)C)(=O)[C@@]1(C)CO1

Sinónimos:

• (2R)-2-[Acetyl-(N-Methyl-L-Isoleucyl)-L-Isoleucyl-L-Threonyl-L-Leucyl]-2-Methyloxirane
• <span class="text-smallcaps">L</smallcap>-Threoninamide, N-acetyl-N-methyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</span>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-
• <span class="text-smallcaps">L</smallcap>-Threoninamide, N-acetyl-N-methyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</span>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
• Bu-4061T
• Epoxomicin, Synthetic
• N-Acetyl-N-Methyl-L-Isoleucyl-L-Isoleucyl-N-[(1S)-3-Methyl-1-[[(2R)-2-Methyloxiranyl]Carbonyl]Butyl]-L-Threoninamide
• N-Acetyl-N-methyl-<span class="text-smallcaps">L</smallcap>-isoleucyl-<smallcap>L</smallcap>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-<smallcap>L</span>-threoninamide
• N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl}-L-leucinamide
• N-acetyl-N-methyl-L-isoleucyl-N-{(2S,3R)-3-hydroxy-2-[(3-methyl-1-{[(2R)-2-methyloxiran-2-yl]carbonyl}butyl)amino]butanoyl}-L-isoleucinamide
• N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-threoninamide
• L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
• L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-
• Epoxomicin
• Epoxomicin(BU-4061T)
• Aids010837
• CS-1626
• Aids-010837
• Epoxomicin, 97%, a selective proteasome inhibitor
• BU-4061T,Aids010837
• (2S,3S)-2-[[(2S,3S)-2-[acetyl(Methyl)aMino]-3-Methylpentanoyl]aMino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl]aMino]butanoyl]-3-MethylpentanaMide
• EPOXOMICIN;BU4061T;BU-4061T
• 134381-21-8 supplier in China

Epoxomicin

CAS: 134381-21-8

Fórmula: C₂₈H₅₀N₄O₇

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 554.7192

Ref: IN-DA007MB6

Epoxomicin

CAS: 134381-21-8

Epoxomicin

Pureza: ≥98%

Peso molecular: 554.72g/mol

Ref: 54-BUP08315

Epoxomicin

CAS: 134381-21-8

Fórmula: C₂₈H₅₀N₄O₇

Pureza: ≥ 98.0%

Cor e Forma: White to off-white or light-yellow solid

Peso molecular: 554.7

Ref: 7W-GL3424

Epoxomicin

CAS: 134381-21-8

Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.

Fórmula: C₂₈H₅₀N₄O₇

Pureza: 98.65% - 98.86%

Cor e Forma: White To Off-White Solid

Peso molecular: 554.72

Ref: TM-T6830

Epoxomicin

CAS: 134381-21-8

Epoxomicin is an activator that binds to the ligand-binding site of a receptor. It has been used as a research tool in cell biology, pharmacology, and immunology. Epoxomicin has been shown to inhibit ion channels by binding to them and blocking their activity. This property makes epoxomicin a good candidate for the treatment of epilepsy. Epoxomicin also inhibits protein synthesis through inhibition of ribosomal S6 kinase, which is involved in signal transduction pathways.

Fórmula: C₂₈H₅₀N₄O₇

Pureza: Min. 95%

Peso molecular: 554.72 g/mol

Ref: 3D-IEP-4381-V

Epoxomicin

CAS: 134381-21-8

Epoxomicin is a macrolide antibiotic that inhibits the production of inflammatory mediators by suppressing the activity of protein kinase C. Epoxomicin has been shown to have anti-inflammatory properties in low doses. This drug also inhibits the proteasome, an enzyme that breaks down proteins into amino acids or small peptides, and is used as an inhibitor of cancer cell proliferation. Epoxomicin binds to the 20S proteasome at a site that is distinct from that for other proteasome inhibitors such as lactacystin and bortezomib, which are used for cancer treatment. The binding site for epoxomicin is adjacent to the ATP-binding site and may be due to its inhibitory effect on ATP hydrolysis.

Fórmula: C₂₈H₅₀N₄O₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 554.72 g/mol

Ref: 3D-JFA38121