CAS 134395-00-9
:Éster tert-butilo de atorvastatina
Descrição:
Éster tert-butilo de atorvastatina, com o número CAS 134395-00-9, é um composto químico que serve como intermediário na síntese de atorvastatina, um medicamento amplamente utilizado para reduzir os níveis de colesterol. Este composto é caracterizado pelo seu grupo funcional éster, que contribui para sua reatividade e propriedades de solubilidade. Normalmente, Éster tert-butilo de atorvastatina é um sólido branco a off-white, e é solúvel em solventes orgânicos como metanol e etanol, mas menos solúvel em água. O grupo tert-butilo aumenta a lipofilicidade da molécula, o que pode influenciar suas propriedades farmacocinéticas. Em termos de estabilidade, o composto é geralmente estável sob condições padrão de laboratório, mas pode ser sensível à hidrólise na presença de umidade. Como intermediário, é crucial na indústria farmacêutica para a produção de atorvastatina, que funciona como um inibidor da HMG-CoA redutase, reduzindo efetivamente a síntese de colesterol no fígado. As condições adequadas de manuseio e armazenamento são essenciais para manter sua integridade e eficácia durante os processos de síntese e formulação.
Fórmula:C37H43FN2O5
InChI:InChI=1S/C37H43FN2O5/c1-24(2)34-33(36(44)39-28-14-10-7-11-15-28)32(25-12-8-6-9-13-25)35(26-16-18-27(38)19-17-26)40(34)21-20-29(41)22-30(42)23-31(43)45-37(3,4)5/h6-19,24,29-30,41-42H,20-23H2,1-5H3,(H,39,44)/t29-,30-/m1/s1
Chave InChI:InChIKey=GCPKKGVOCBYRML-LOYHVIPDSA-N
SMILES:C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(OC(C)(C)C)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4
Sinónimos:- (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester
- (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dihydroxy-4-acetate
- (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester
- 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1,1-dimethylethyl ester, (βR,δR)-
- 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1,1-dimethylethyl ester, [R-(R*,R*)]-
- L-2
- L2
- Atorvastatin Impurity 21
- (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-DiMethylethyl Ester
- (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole
- Atorvastatin tert-Butyl Ester
- (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)
- Atorvastatin 1
- 7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic Acid tert-Butyl Ester
- (3R,5R)
- -tert-Butyl 7-(2-(4-fluorophenyl)
- (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-
- (4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dihydroxy-4-acetate
- (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
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8 produtos.
Atorvastatin tert-Butyl Ester (tert-butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate)
CAS:Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFórmula:C37H43FN2O5Cor e Forma:White Off-White SolidPeso molecular:614.3156(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS:Fórmula:C37H43FN2O5Pureza:98%Cor e Forma:SolidPeso molecular:614.7461Atorvastatin EP Impurity N (Atorvastatin tert-Butyl Ester)
CAS:Fórmula:C37H43FN2O5Cor e Forma:White To Off-White SolidPeso molecular:614.76(bR,deltaR)-Atorvastatin tert-Butyl Ester (>90%)
CAS:Produto Controlado<p>Applications An impurity arising in the synthesis of Atorvastatin. Atorvastatin Tert Butyl Ester<br></p>Fórmula:C37H43FN2O5Pureza:>90%Cor e Forma:NeatPeso molecular:614.75Atorvastatin-d5 tert-Butyl Ester
CAS:Produto Controlado<p>Applications Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>Fórmula:C37H38D5FN2O5Cor e Forma:NeatPeso molecular:619.78Atorvastatin tert-butyl ester
CAS:<p>Atorvastatin tert-butyl ester is an acid that is used to treat high cholesterol. It is a synthetic statin that inhibits the enzyme HMG-CoA reductase and blocks the production of cholesterol in the liver. This drug is administered orally, as a tablet or capsule, or in liquid form as a suspension. The drug has a bitter taste and evaporation may occur if it comes into contact with skin or clothes. Atorvastatin tert-butyl ester may be found in polymorphic forms (including dihydropyridine, dihydrospirocyclopentane, and dihydrobenzoquinoline). These forms are inactive, but can be activated by exposure to light or heat. These reactions produce an acidic compound that can react with other compounds to form new compounds.</p>Fórmula:C37H43FN2O5Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:614.75 g/mol
