CAS 134418-28-3

Desidroandrographolide

Descrição:

Desidroandrographolide é um composto natural derivado da planta Andrographis paniculata, comumente conhecido por suas propriedades medicinais. É uma lactona diterpenoide bicíclica, caracterizada por sua estrutura complexa que inclui múltiplos anéis e grupos funcionais. Este composto exibe uma gama de atividades biológicas, incluindo propriedades anti-inflamatórias, antioxidantes e antimicrobianas, tornando-o de interesse na pesquisa farmacológica. Desidroandrographolide tem sido estudado por seus potenciais efeitos terapêuticos em várias condições, incluindo infecções e doenças inflamatórias. Seu mecanismo de ação geralmente envolve a modulação de vias de sinalização e a inibição de citocinas pró-inflamatórias. Além disso, é conhecido por interagir com vários alvos biológicos, contribuindo para seus diversos efeitos farmacológicos. O composto é tipicamente analisado usando técnicas como cromatografia e espectroscopia para determinar sua pureza e concentração em ambientes de pesquisa. No geral, Desidroandrographolide representa uma área significativa de estudo na química de produtos naturais e no desenvolvimento de medicamentos, destacando a importância dos compostos derivados de plantas na medicina moderna.

Fórmula: C₂₀H₂₈O₅

InChI: InChI=1/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16?,17-,19+,20+/m1/s1

Chave InChI: InChIKey=YIIRVUDGRKEWBV-CZUXAOBFSA-N

SMILES: C[C@]12[C@@]([C@@](CO)(C)[C@H](O)CC1)(CCC(=C)[C@@H]2C/C=C\3/C(=O)OC=C3)[H]

Sinónimos:

• (2R,5R,10R)-2,17-dihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,15-octahydro-20:5,10-dicycloretinal
• (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone
• 14-(P)
• 14-Deoxy-11-dehydroandrographolide
• 2(3H)-Furanone, 3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, (3E)-
• 2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, [1R-[1α,2α,4aα,5β(E),8aβ]]-
• DEOXY-11,12-DiDehydroandrographolide
• Dehydroanddrographolide
• Dehydroandrographoline
• andrographolide, Dehydro-
• Dehydroandrographolide
• Dehydrographkide
• 2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-

(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone

CAS: 134418-28-3

Fórmula: C₂₀H₂₈O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 332.4339

Ref: IN-DA009AGI

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide

Pureza: ≥98%

Peso molecular: 332.43g/mol

Ref: 54-BUP06369

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.

Fórmula: C₂₀H₂₈O₄

Pureza: 99.98%

Cor e Forma: Solid

Peso molecular: 332.43

Ref: TM-T2738

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. It possesses activity against HBV DNA replication with IC50 values of 22.58 uM and low SI values of 8.7 ; it can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Fórmula: C₂₀H₂₈O₄

Pureza: 95%~99%

Peso molecular: 332.44

Ref: BP-BP0459

Dehydroandrographolide

CAS: 134418-28-3

Fórmula: C₂₀H₂₈O₄

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 332.43

Ref: 7W-GP8945

Dehydroandrographolide

CAS: 134418-28-3

Lactone

Fórmula: C₂₀H₂₈O₄

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 332.44

Ref: 5G-89623

Dehydroandrographoline

CAS: 134418-28-3

Dehydroandrographolide is a natural product that has been used in traditional medicine to treat bowel disease, diabetes, and cancer. This compound is found in the plant Andrographis paniculata and has been shown to inhibit P-glycoprotein (P-gp) efflux transporter activity. Dehydroandrographolide also induces autophagy, which is the process by which cells degrade their own components under conditions of nutrient starvation or other stress. In addition, dehydroandrographolide succinate inhibits potassium channel activity and may be a potential anticancer agent. The analytical method for dehydroandrographolide succinate is based on an acid hydrolysis followed by high performance liquid chromatography with UV detection at λ max 218 nm.

Fórmula: C₂₀H₂₈O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 348.43 g/mol

Ref: 3D-FD11384