CAS 134523-00-5

Atorvastatina

Descrição:

Atorvastatina é um agente sintético redutor de lipídios que pertence à classe das estatinas, utilizado principalmente para gerenciar a hiperlipidemia e reduzir o risco de doenças cardiovasculares. Seu mecanismo de ação envolve a inibição da HMG-CoA redutase, uma enzima crítica na via de biossíntese do colesterol, levando a níveis diminuídos de lipoproteína de baixa densidade (LDL) e colesterol total na corrente sanguínea. Atorvastatina é caracterizado por sua fórmula molecular, que inclui átomos de carbono, hidrogênio, nitrogênio e oxigênio, refletindo sua estrutura complexa. O composto é tipicamente administrado por via oral e apresenta boa biodisponibilidade. É metabolizado principalmente no fígado, com uma parte significativa passando pelo metabolismo de primeira passagem. Efeitos colaterais comuns podem incluir dor muscular, alterações nas enzimas hepáticas e distúrbios gastrointestinais. Atorvastatina é frequentemente prescrito em conjunto com modificações no estilo de vida, como dieta e exercício, para aumentar sua eficácia na redução dos níveis de colesterol. Seus benefícios terapêuticos, juntamente com os riscos potenciais, exigem monitoramento cuidadoso por parte dos profissionais de saúde durante o tratamento.

Fórmula: C₃₃H₃₅FN₂O₅

InChI: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1

Chave InChI: InChIKey=XUKUURHRXDUEBC-KAYWLYCHSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4

Sinónimos:

• (3R,5R)-7-[2-(4-Fluorophenyl)-3-Phenyl-4-(Phenylcarbamoyl)-5-Propan-2-Yl-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (3S,5S)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (3S,5S)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
• (βR,δR)-2-(p-Fluorophenyl)-β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid
• 1H-Pyrrole-1-Heptanoic Acid
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-rel-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, [R-(R*,R*)]-
• 1H-pyrrole-1-heptanoate, 3-benzoyl-5-(4-fluorophenyl)-β,δ-dihydroxy-2-(1-methylethyl)-4-phenyl-, calcium salt, (betaR,deltaR)- (1:1)
• Atavastatin
• Atofast
• Atorcor
• Atorfit 20
• Atorin
• Atoris
• Atorvastatin Acid
• Atorvox
• Atrox
• Cardyl
• Lipilou
• Lipinon
• Statofilm
• calcium bis{(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate}

Atorvastatin Calcium Salt Trihydrate

CAS: 134523-00-5, 134523-03-8, 344423-98-9

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀·3H₂O

Pureza: >98.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 1,209.41

Ref: 3B-A2476

(3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

CAS: 134523-00-5

Fórmula: C₃₃H₃₅FN₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 558.6398

Ref: IN-DA00384N

Atorvastatin

CAS: 134523-00-5

Fórmula: C₃₃H₃₅FN₂O₅

Pureza: ≥ 98%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 558.64

Ref: 7W-GP7735

Des-(N-Phenyl)Carbamoyl Atorvastatin Calcium Salt

Produto Controlado

CAS: 134523-00-5, 2247346-41-2

Fórmula: (C₂₆H₂₉FNO₄)•Ca

Cor e Forma: Neat

Peso molecular: 2(438.52) + (40.08)

Ref: TR-F621870

Atorvastatin acid

CAS: 134523-00-5

Atorvastatin acid is a pharmaceutical compound belonging to the class of statins, which is a synthetic derivative of fungal metabolites. It functions as an HMG-CoA reductase inhibitor, playing a critical role in the cholesterol biosynthesis pathway. By inhibiting this key enzyme, atorvastatin acid effectively reduces the conversion of HMG-CoA to mevalonate, a precursor of cholesterol, thus lowering overall cholesterol levels in the bloodstream.

Fórmula: C₃₃H₃₅FN₂O₅

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 558.64 g/mol

Ref: 3D-FF59474

Atorvastatin

CAS: 134523-00-5

Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.

Fórmula: C₃₃H₃₅FN₂O₅

Pureza: 99.37% - 99.69%

Cor e Forma: Solid

Peso molecular: 558.64

Ref: TM-T20765

(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid

CAS: 134523-00-5

Fórmula: C₃₃H₃₅FN₂O₅

Pureza: 98.0%

Cor e Forma: Solid, White powder

Peso molecular: 558.65

Ref: 10-F079255

3-Fluoro Atorvastatin Sodium Salt-d5

Produto Controlado

CAS: 134523-00-5

Fórmula: C₃₃D₅H₂₉FN₂NaO₅

Cor e Forma: Neat

Peso molecular: 585.652

Ref: TR-F587917

3-Fluoro Atorvastatin Sodium Salt

Produto Controlado

CAS: 134523-00-5

Applications 3-Fluoro Atorvastatin Sodium Salt is an impurity of Atorvastatin (A791750, Ca Salt); a selective, competitive HMG-CoA reductase inhibitor and the only drug in its class specifically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Fórmula: C₃₃H₃₄FN₂NaO₅

Cor e Forma: Neat

Peso molecular: 580.62

Ref: TR-F587915