CAS 134523-03-8

Atorvastatina cálcica

Descrição:

Atorvastatina cálcica é um composto farmacêutico utilizado principalmente como agente redutor de lipídios para gerenciar a hiperlipidemia e reduzir o risco de doenças cardiovasculares. Pertence à classe de medicamentos conhecidos como estatinas, que funcionam inibindo a enzima HMG-CoA redutase, um jogador chave na biossíntese de colesterol no fígado. Essa ação leva a uma diminuição do colesterol de lipoproteína de baixa densidade (LDL) e triglicerídeos, enquanto aumenta os níveis de colesterol de lipoproteína de alta densidade (HDL). A atorvastatina é tipicamente administrada por via oral e é bem absorvida no trato gastrointestinal. Sua solubilidade é influenciada pelo pH, com melhor solubilidade em condições ácidas. O composto é caracterizado por sua fórmula molecular, que reflete sua estrutura complexa, e existe como um sal de cálcio para melhorar sua estabilidade e biodisponibilidade. Efeitos colaterais comuns podem incluir dor muscular, alterações nas enzimas hepáticas e distúrbios gastrointestinais. Assim como todos os medicamentos, a atorvastatina deve ser usada sob supervisão médica, considerando possíveis interações com outros medicamentos e perfis de saúde individuais dos pacientes.

Fórmula: C₆₆H₆₈Ca₂F₂N₄O₁₀

InChI: InChI=1/2C33H35FN2O5.2Ca.2H/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;;;/q;;;+2;;/p-2/t2*26-,27-;;;;/m11..../s1/r2C33H35FN2O5.CaH2.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);1H2;/q;;;+2/p-2/t2*26-,27-;;/m11../s1

Chave InChI: InChIKey=BWFCZHDTTAYGNN-CNZCJKERSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Ca]

Sinónimos:

• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5-Dihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt(L-4)
• (R-(R*,R*))-, Atorvastatin calcium
• 1H-Pyrrole-1-Heptanoicacid,Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methy Calciumsalt(2:1),(R-(R*,R*))-Lethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1), (R-(R*,R*))-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), [R-(R*,R*)]-
• 1H-Pyrrole-1-heptanoic acid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1)
• Atocor
• Atoraz
• Atorvastatin Ca
• Atorvastatin Calcium Anhydrous
• Atorvastatin Calsium
• Atorvastatin calcium (USAN)
• Atorvastatin calcium salt
• Atorvastatin hemicalcium
• Atorvastatin hemicalcium salt
• Atorvastatincalcuim
• Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Calcium Salt(2:1)
• C08078
• Calcium (betaR,deltaR)-2-(p-fluorophenyl)-beta,delta-dihydroxy-5-isopr opyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate (1:2)
• Ci-981
• D00887
• Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Betcalci1H-Pyrrole-1-Heptanoicaci
• Drg-0321
• L-4
• Lipibec
• Lipitor
• Lipitor (TN)
• Lorvast
• Lowlip
• Ls-136974
• Pd 134298-38A
• Pd134298-38A
• Prevencor
• Rotacor
• Sortis
• Storvas
• Tahor
• Torvast
• Ym-548
• [R-(R*, R*)]-7-[2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-(Phenylaminocarbonyl)-1H-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid Calcium Salt
• calcium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-p ropan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoate
• Atorvastatin calcium
• calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl)
• (3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5-Dihydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5 ydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy
• Atrovastatin calcium
• (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid
• ATORVASTATINE CADIUM
• 3S,5S-Atorvastatin
• Atorvastatin Calclum
• ATORVASTATIN CALCIUM MM(CRM STANDARD)

Atorvastatin Calcium Salt Trihydrate

CAS: 134523-00-5, 134523-03-8, 344423-98-9

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀·3H₂O

Pureza: >98.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 1,209.41

Ref: 3B-A2476

Atorvastatin Calcium

CAS: 134523-03-8

Cor e Forma: Neat

Ref: 61-FOR0400.00

Atorvastatin calcium

CAS: 134523-03-8

Atorvastatin calcium

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀

Pureza: 95.1%

Cor e Forma: White

Peso molecular: 1154.45294

Ref: 47-1267

1H-Pyrrole-1-heptanoicacid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calciumsalt(2:1),(βR,δR)-

CAS: 134523-03-8

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1155.3417

Ref: IN-DA00368S

Atorvastatin calcium salt

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·5Ca·5H₂O

Pureza: 98.0 - 102.0 % (anhydrous basis)

Cor e Forma: White to almost white crystalline powder

Peso molecular: 604.69

Ref: 7W-GP5009

Atorvastatin Calcium Salt

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·5Ca

Cor e Forma: White To Off-White Solid

Peso molecular: 557.65 0.5*40.08

Ref: 4Z-A-121

Atorvastatin hemicalcium salt (Standard)

CAS: 134523-03-8

Atorvastatin hemicalcium salt (Standard) is the standard substance of Atorvastatin hemicalcium salt, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol.

Fórmula: C₃₃H₃₄FN₂O₅Ca

Cor e Forma: White Crystalline Powder

Peso molecular: 577.67

Ref: TM-TMSM-0471

Atorvastatin calcium

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Cor e Forma: Neat

Peso molecular: 1155.34

Ref: 04-C10318000

Atorvastatin Calcium

Produto Controlado

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Cor e Forma: Neat

Peso molecular: 1155.34

Ref: 86-MM0400.00

Atorvastatin hemicalcium salt

CAS: 134523-03-8

Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.

Fórmula: C₃₃H₃₄FN₂O₅Ca

Pureza: 99.27% - >99.99%

Cor e Forma: White Crystalline Powder

Peso molecular: 577.67

Ref: TM-T3116

Atorvastatin Impurity 61

CAS: 134523-03-8

Fórmula: C₄₀H₄₇FN₂O₆

Cor e Forma: White To Off-White Solid

Peso molecular: 670.82

Ref: 4Z-A-12102

Atorvastatin Calcium Salt

Produto Controlado

CAS: 134523-03-8

Applications A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Zhao Y et al. Medicine (Baltimore). 2017 Feb;96(7):e6104.Wu X et al. Carcinogenesis. 2017 Feb 16Sepehri Z et al. PLoS One. 2017 Feb 13;12(2):e0172404

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Cor e Forma: White

Peso molecular: 1155.34

Ref: TR-A791750

Atorvastatin Calcium Salt

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Ref: TR-TRC-A791750

Atorvastatin calcium salt - Bio-X ™

CAS: 134523-03-8

Atorvastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.

Fórmula: (C₃₃H₃₅FN₂O₅)₂•Ca

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,157.36 g/mol

Ref: 3D-BA164226

Atorvastatin calcium

CAS: 134523-03-8

HMG-CoA reductase inhibitor; anti-hypercholesterolemia agent

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀

Pureza: Min. 97 Area-%

Cor e Forma: White Powder

Peso molecular: 1,155.34 g/mol

Ref: 3D-FA57652