CAS 1346574-57-9

N-[(1,2-Diidro-4,6-dimetil-2-oxo-3-piridinil)metil]-3-metil-1-[(1S)-1-metilpropil]-6-[6-(1-piperazinil)-3-piridinil]-1H-indol-4-carboxamida

Descrição:

A substância química N-[(1,2-Diidro-4,6-dimetil-2-oxo-3-piridinil)metil]-3-metil-1-[(1S)-1-metilpropil]-6-[6-(1-piperazinil)-3-piridinil]-1H-indol-4-carboxamida, com número CAS 1346574-57-9, é um composto orgânico complexo caracterizado por sua estrutura de múltiplos anéis, que inclui moieties de indol e piridina. Este composto apresenta vários grupos funcionais, incluindo amidas e cetonas, que contribuem para sua potencial atividade biológica. A presença de piperazina sugere possíveis interações com alvos biológicos, tornando-o de interesse na química medicinal. Sua estrutura molecular indica potencial lipofilia, o que pode influenciar suas propriedades farmacocinéticas, como absorção e distribuição em sistemas biológicos. A síntese e caracterização do composto normalmente envolveriam técnicas avançadas de química orgânica, e sua estabilidade, solubilidade e reatividade seriam críticas para aplicações no desenvolvimento de medicamentos ou pesquisa. No geral, essa substância representa uma classe de compostos que podem exibir um potencial terapêutico significativo, justificando uma investigação mais aprofundada sobre seus efeitos biológicos e mecanismos de ação.

Fórmula: C₃₁H₃₈N₆O₂

InChI: InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1

Chave InChI: InChIKey=FKSFKBQGSFSOSM-QFIPXVFZSA-N

SMILES: [C@@H](CC)(C)N1C=2C(=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C2)C=4C=CC(=NC4)N5CCNCC5)C(C)=C1

Sinónimos:

• GSK 2816126A
• N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
• 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-
• N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
• GSK 126
• 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide
• GSK-2816126
• 1-(S)-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
• GSK126, >=98%
• S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
• N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide GSK126

GSK126

CAS: 1346574-57-9

GSK126

Pureza: ≥98%

Peso molecular: 526.67g/mol

Ref: 54-BUP15338

GSK126

CAS: 1346574-57-9

GSK126

Pureza: 98%

Peso molecular: 526.67g/mol

Ref: 54-BISN0124

GSK126

CAS: 1346574-57-9

GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).

Fórmula: C₃₁H₃₈N₆O₂

Pureza: 98% - 99.67%

Cor e Forma: Solid

Peso molecular: 526.67

Ref: TM-T2079

GSK 126

CAS: 1346574-57-9

GSK-126 is a potent inhibitor of histone lysine methyl transferase 2, which is encoded by the enhancer of zeste homolog 2 gene (EZH2). The EZH2 protein regulates cell cycle as it represses the Polycomb-Repressive Complex 2 (PRC2), allowing cells to divide actively. GSK-126 inhibits the EZH2 by targeting the catalytic domain (SET) of the enzyme and therefore blocks the PCR2 repression mechanism, resulting in cell proliferation arrest. The compound has shown therapeutic potential for a variety of cancers.

Fórmula: C₃₁H₃₈N₆O₂

Pureza: Min. 95%

Cor e Forma: White To Yellow Solid

Peso molecular: 526.30562

Ref: 3D-FB43076

GSK126

CAS: 1346574-57-9

Applications GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.
References McCabe, M.T., et al.: Nature., 492, 108 (2012);

Fórmula: C₃₁H₃₈N₆O₂

Cor e Forma: Neat

Peso molecular: 526.67

Ref: TR-G797650