CAS 13553-79-2
:Rifamicina S
Descrição:
Rifamicina S é um antibiótico natural pertencente à classe das rifamicinas, derivado principalmente da bactéria Amycolatopsis rifamycinica. É caracterizado por sua complexa estrutura macrocíclica, que inclui um núcleo naftalênico e um cromóforo rifamicina característico. Este composto exibe uma potente atividade antibacteriana, particularmente contra Mycobacterium tuberculosis, tornando-o significativo no tratamento da tuberculose e outras infecções bacterianas. Rifamicina S atua inibindo a síntese de RNA bacteriano através da ligação à RNA polimerase dependente de DNA, impedindo assim a transcrição. A substância é tipicamente administrada em suas formas derivadas, como a rifampicina, que melhora suas propriedades farmacológicas. Além de sua eficácia antimicrobiana, Rifamicina S tem um perfil de toxicidade relativamente baixo, embora possa causar efeitos colaterais como elevação das enzimas hepáticas e reações de hipersensibilidade em alguns pacientes. Suas características de solubilidade variam, influenciando sua formulação e métodos de entrega em ambientes clínicos. No geral, Rifamicina S é um composto crucial no campo da terapia antimicrobiana, particularmente para cepas bacterianas resistentes.
Fórmula:C37H45NO12
InChI:InChI=1/C37H45NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,41-43H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
Chave InChI:InChIKey=BTVYFIMKUHNOBZ-ODRIEIDWSA-N
SMILES:O=C1C=2C3=C4C(=O)C(=CC3=O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O
Sinónimos:- (14E,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
- (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
- 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
- 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin
- 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
- 5,17,19-Trihydroxy-23-Methoxy-2,4,12,16,18,20,22-Heptamethyl-1,6,9,11-Tetraoxo-1,2,6,9-Tetrahydro-2,7-(Epoxypentadeca[1,11,13]Trienoimino)Naphtho[2,1-B]Furan-21-Yl Acetate
- Brn 0604802
- Nci 144-130
- Nsc 144130
- Rifamycin, 1,4-dideoxy-1,4-dihydro-1,4-dioxo-
- Rifomycin S
- Unii-Pi53N820Jv
- RIFAMYCIN S
- Rifamycin S CRS
- rifamycin
- RIFAMPICIN S
- 2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2h)-tetron
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate (7CI,8CI)
- Rifamycin Impurity 2(Rifamycin EP Impurity B)（Rifamycin S)
- Rifaximin impurity E (EP)
- Rifaximin EP Impurity E (Rifamycin S)
- Rifamycin EP Impurity B
- 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-aceta
- 100722
- rifomycins
- nci144-130
- 5,17,19,21-Tetrahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-2,7-(epoxypentadeca[1,11,13]trieniMino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone 21-Acetate
- Rifamycin S USP/EP/BP
- Rifaximin Impurity 5 (Rifaximin EP Impurity E)
- 4-dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
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12 produtos.
Rifamycin S
CAS:Fórmula:C37H45NO12Pureza:>98.0%(HPLC)Cor e Forma:Light yellow to Brown powder to crystalPeso molecular:695.762,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate (7CI,8CI)
CAS:Fórmula:C37H45NO12Pureza:97%Cor e Forma:SolidPeso molecular:695.7527Ref: IN-DA0035KK
1g26,00€5g35,00€15g65,00€1kg683,00€25g74,00€5kgA consultar100g190,00€10kgA consultarRifaximin EP Impurity E (Rifamycin S)
CAS:Fórmula:C37H45NO12Cor e Forma:Orange SolidPeso molecular:695.76Rifamycin S
CAS:Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteriaFórmula:C37H45NO12Pureza:98.74%Cor e Forma:Yellow Orange Crystalline PowderPeso molecular:695.75Rifamycin S
CAS:Produto Controlado<p>Impurity Rifaximin EP Impurity E<br>Applications Rifamycin S (Rifaximin EP Impurity E) is a semi-synthetic antibiotic.<br>References Li, J., et al.: Bioorg. Med. Chem. Lett., 17, 5510 (2007), Patil, R., et al.: J. Pure & App. Microbiol., 2, 211 (2008),<br></p>Fórmula:C37H45NO12Cor e Forma:NeatPeso molecular:695.75Rifamycin S
CAS:<p>Rifamycin S is a rifamycin that is used as a model system to study the activity of other drugs. It is also used to treat infectious diseases, such as bowel disease, by inhibiting bacterial growth. Rifamycin S has been shown to have drug interactions with other drugs and can cause acute toxicities in the form of multivariate logistic regression. It has also been shown to inhibit the enzymatic inactivation of a number of antibiotics, such as methicillin and penicillin, which may be due to its ability to bind DNA templates. Rifamycin S has also been shown to have antibacterial effects against some bacteria, including Mycobacterium tuberculosis and Mycobacterium avium.</p>Fórmula:C37H45NO12Pureza:Min. 96 Area-%Cor e Forma:PowderPeso molecular:695.75 g/mol
![2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrah…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0035KK.jpg&w=3840&q=75)
