CAS 136553-81-6

B Q-123

Descrição:

B Q-123, identificado pelo seu número CAS 136553-81-6, é um composto químico que tem atraído atenção em várias áreas, particularmente em química medicinal e farmacologia. É caracterizado por sua estrutura molecular específica, que contribui para sua atividade biológica única. B Q-123 é conhecido por atuar como um antagonista seletivo de certos receptores, influenciando vários processos fisiológicos. Sua solubilidade, estabilidade e reatividade são fatores importantes que determinam sua aplicação em pesquisa e potenciais usos terapêuticos. Além disso, B Q-123 pode exibir interações específicas com outras biomoléculas, o que pode ser crítico para sua função em sistemas biológicos. Diretrizes de segurança e manuseio são essenciais ao trabalhar com este composto, assim como com qualquer substância química, para mitigar quaisquer perigos potenciais. No geral, B Q-123 representa um composto significativo no estudo de interações de receptores e desenvolvimento terapêutico, embora informações detalhadas sobre suas aplicações e efeitos específicos possam variar com base na pesquisa em andamento.

Fórmula: C₃₁H₄₂N₆O₇

InChI: InChI=1/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)

SMILES: CC(C)CC1C(=NC(Cc2c[nH]c3ccccc23)C(=NC(CC(=O)O)C(=O)N2CCCC2C(=NC(C(C)C)C(=N1)O)O)O)O

Sinónimos:

• cyclo(D-asp-pro-D-val-leu-D-trp)
• Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)
• D-alpha-aspartyl-L-prolyl-D-valyl-N-[(2R)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-4-methylidene-L-norvalinamide
• cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• Cyclo(Alpha-Aspartylprolylvalylleucyltryptophyl)
• Bq-123 Sodium Salt
• Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-)
• ETA-RECEPTOR ANTAGONIST
• cyclo(Trp-Asp-Pro-Val-Leu)
• BQ-123 >=99%, sodium salt, lyophilized powder
• D-TRP-D-ASP-PRO-D-VAL-LEU
• BQ-123;BQ 123;BQ123
• BQ-518
• Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]
• BQ-123
• C(DTRP-DASP-PRO-DVAL-LEU)
• 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl
• BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE
• PMZ 2123
• M.W. 610.70 C31H42N6O7
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT
• 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
• CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA)

BQ-123

CAS: 136553-81-6

BQ-123 is a potent endothelin antagonist with high selectivity for the ET-A receptor subtype.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: 98.4%

Cor e Forma: Yellow

Peso molecular: 610.71

Ref: 01-4016690

Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

CAS: 136553-81-6

Fórmula: C₃₁H₄₂N₆O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 610.7012

Ref: IN-DA009ARV

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

CAS: 136553-81-6

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

Pureza: 98%

Peso molecular: 610.7g/mol

Ref: 54-OR1023197

BQ-123

CAS: 136553-81-6

BQ-123

Pureza: ≥95%

Peso molecular: 610.7g/mol

Ref: 54-BUP08189

BQ-123

CAS: 136553-81-6

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: 99.22% - ≥95%

Cor e Forma: Solid

Peso molecular: 610.7

Ref: TM-T6792

BQ-123-d7

CAS: 136553-81-6

Fórmula: C₃₁H₃₅D₇N₆O₇

Peso molecular: 617.75

Ref: 4Z-PB-200002

BQ-123 [Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)]

CAS: 136553-81-6

Fórmula: C₃₁H₄₂N₆O₇

Peso molecular: 610.71

Ref: 4Z-PB-200001

BQ-123-13C6-15N

CAS: 136553-81-6

Fórmula: C₂₅₁₃C₆H₄₂N₅₁₅NO₇

Peso molecular: 617.66

Ref: 4Z-PB-200003

BQ-123 Sodium Salt

CAS: 136553-81-6

BQ-123 is a cyclic peptide that blocks the endothelin-A receptor. It has been shown to be an effective treatment for pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. BQ-123 binds to the endothelin-A receptor, which is located on the surface of cells in many tissues throughout the body. When bound, it inhibits intracellular calcium concentrations by reducing voltage-gated calcium channels and prevents the release of neurotransmitters. BQ-123 also has a stabilizing effect on hydrogen bonds due to its charged side chains. This property may account for its ability to form stable complexes with other proteins, inhibiting their function.
BQ-123 has been shown to have an active binding site on cyclic AMP response element binding protein (CREB) that inhibits CREB activity, thereby reducing protein synthesis. It also blocks cyclic GMP (cGMP)-dependent protein kin

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.70 g/mol

Ref: 3D-PED-3512-PI

BQ-123 Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)

CAS: 136553-81-6

BQ-123 is a cyclic peptide that has been shown to have a binding affinity for the serotonin receptor. The binding of BQ-123 to the receptor leads to a reduction in intracellular calcium concentration, which may be due to the inhibition of serine protease activity. This agent also inhibits the production of tumour necrosis factor-α (TNF-α) and has an inhibitory effect on cardiac contractility.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.7 g/mol

Ref: 3D-FB108394