CAS 136572-09-3

Cloridrato de irinotecano tri-hidratado

Descrição:

Cloridrato de irinotecano tri-hidratado é um agente quimioterápico utilizado principalmente no tratamento do câncer colorretal. É um sal solúvel em água derivado do alcaloide natural camptotecina e funciona como um inibidor da topoisomerase I, interrompendo a replicação e transcrição do DNA nas células cancerosas. A substância aparece como um pó cristalino branco a off-white e é higroscópica, o que significa que pode absorver umidade do ambiente. Sua fórmula molecular inclui um componente de cloridrato e três moléculas de água, contribuindo para sua estabilidade e solubilidade em soluções aquosas. O irinotecano é administrado por via intravenosa e é frequentemente utilizado em combinação com outros agentes quimioterápicos para aumentar a eficácia. Os efeitos colaterais comuns incluem diarreia, náuseas e mielossupressão, exigindo monitoramento cuidadoso durante o tratamento. A farmacocinética do composto envolve metabolismo principalmente pelo fígado, com metabolitos ativos contribuindo para seus efeitos terapêuticos e toxicidade. No geral, Cloridrato de irinotecano tri-hidratado desempenha um papel significativo na oncologia, particularmente no manejo de cânceres em estágios avançados.

Fórmula: C₃₃H₃₈N₄O₆·ClH·3H₂O

InChI: InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

Chave InChI: InChIKey=KLEAIHJJLUAXIQ-JDRGBKBRSA-N

SMILES: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)N6CCC(CC6)N7CCCCC7)=CC5.Cl.O

Sinónimos:

• (+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate
• (+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate
• (1,4'-Bipiperidine)-1'-Carboxylicacid,4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hyd Monohydrochloride, Trihydrate
• (1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
• (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate trihydrate hydrochloride
• (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
• (S)-[1,4'-Bipiperidine]-1'-Carboxylic Acid 4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
• (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
• Camptosar
• Irinotecan HCl trihydrate
• Irinotecan Monohydrochloride Trihydrate
• Irinotecan hydrochloride hydrate
• Irinotecanhydrochloridetrihydrate(Cpt-11)
• Onivyde
• Onivyde pegylated liposomal
• Roxy-3,14-Dioxo-1H-Pyrano(3',4',6,7)Indolizino(1,2-B)Quinolin-9-Ylester,Mono
• Trihydrate,(S)-Hydrochlorid Trihydrate
• [1,4'-Bipiperidine]-1'-Carboxylic Acid (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
• [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate
• [1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
• [3',4',6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester, Hcl Trihydrate

Irinotecan Hydrochloride Trihydrate

CAS: 100286-90-6, 136572-09-3, 97682-44-5

Fórmula: C₃₃H₃₈N₄O₆·HCl·3H₂O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Orange to Green powder to crystal

Peso molecular: 677.20

Ref: 3B-I0714

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Pureza: 98%

Peso molecular: 677.19

Ref: 10-F987649

Irinotecan hydrochloride trihydrate, 99%

CAS: 136572-09-3

Topoisomerase I inhibitor

Fórmula: C₃₃H₄₅ClN₄O₉

Pureza: 99%

Peso molecular: 677.19

Ref: 02-J62370

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

Cor e Forma: Neat

Ref: 61-FOR1157.00

IRINOTECAN HYDROCHLORIDE TRIHYDRATE CRS

CAS: 136572-09-3

IRINOTECAN HYDROCHLORIDE TRIHYDRATE CRS

Fórmula: C₃₃H₃₈N₄O₆

Cor e Forma: Powder. Yellow. Light Yellow.

Peso molecular: 586.678

Ref: 41-Y0001832

IRINOTECAN FOR SYSTEM SUITABILITY 2 CRS

CAS: 136572-09-3

IRINOTECAN FOR SYSTEM SUITABILITY 2 CRS

Fórmula: C₃₃H₃₈N₄O₆

Cor e Forma: Powder. Yellow. Light Yellow.

Peso molecular: 586.678

Ref: 41-Y0001833

IRINOTECAN FOR PEAK IDENTIFICATION CRS

CAS: 136572-09-3

IRINOTECAN FOR PEAK IDENTIFICATION CRS

Fórmula: C₃₃H₃₈N₄O₆

Cor e Forma: Powder. Yellow. Light Yellow.

Peso molecular: 586.678

Ref: 41-Y0001831

IRINOTECAN FOR SYSTEM SUITABILITY 1 CRS

CAS: 136572-09-3

IRINOTECAN FOR SYSTEM SUITABILITY 1 CRS

Ref: 41-Y0001830

Irinotecan Hydrochloride

CAS: 136572-09-3

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

Fórmula: C₃₃H₃₈N₄O₆·HCl·3H₂O

Cor e Forma: Pale Yellow Yellow Powder

Peso molecular: 586.27913

Ref: 45-1347609

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Fórmula: C₃₃H₄₅ClN₄O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 677.1848

Ref: IN-DA003R17

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.

Fórmula: C₃₃H₄₅ClN₄O₉

Pureza: 98.22% - >99.99%

Cor e Forma: Pale Yellow To Yellow Crystalline Powder

Peso molecular: 677.18

Ref: TM-T0486

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate

Pureza: ≥98%

Peso molecular: 677.18g/mol

Ref: 54-BUP17827

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Fórmula: C₃₃H₃₈N₄O₆·HCl·3(H₂O)

Pureza: ≥ 99.0% (anhydrous)

Cor e Forma: Off-white to yellow crystalline powder

Peso molecular: 623.14 (anhydrous)

Ref: 7W-GP2560

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

Irinotecan Hydrochloride Trihydrate

Pureza: 98%

Peso molecular: 677.18g/mol

Ref: 54-OR1026723

Irinotecan Hydrochloride Trihydrate

Produto Controlado

CAS: 136572-09-3

Fórmula: C₃₃H₃₈N₄O₆·ClHH₂O

Cor e Forma: Neat

Peso molecular: 677.18

Ref: 86-MM1157.00

Irinotecan Hydrochloride Trihydrate

Produto Controlado

CAS: 136572-09-3

Applications Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)

Fórmula: C₃₃H₃₈N₄O₆·ClH·3H₂O

Cor e Forma: Light Yellow

Peso molecular: 677.18

Ref: TR-I767500

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

Fórmula: C₃₃H₃₈N₄O₆HCl(H₂O)

Peso molecular: 586.69 : 36.46 : 3(18.0)

Ref: ST-EA-CP-I9016

Irinotecan hydrochloride trihydrate - Bio-X ™

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor that is used as chemotherapy drug for colorectal cancer. By inhibiting topoisomerase I, Irinotecan hydrochloride trihydrate prevents the replication of DNA in cells, and stops the cancer cells from growing and dividing. When used for chemotherapy, Irinotecan hydrochloride trihydrate is usually part of combination therapy with other chemotherapy drugs, such as 5-fluorouracil (5-FU) and leucovorin for other cancers.

Fórmula: C₃₃H₃₈N₄O₆•HCl•(H₂O)₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 677.18 g/mol

Ref: 3D-BI164583

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Inhibitor of DNA topoisomerase I

Fórmula: C₃₃H₃₈N₄O₆•HCl•(H₂O)₃

Pureza: Min. 97 Area-%

Cor e Forma: Yellow Powder

Peso molecular: 677.18 g/mol

Ref: 3D-FI10828

(R)-Irinotecan Hydrochloride-d10 Trihydrate

Produto Controlado

CAS: 1255644-71-3, 136572-09-3

Fórmula: C₃₃H₃₅D₁₀ClN₄O₉

Cor e Forma: Neat

Peso molecular: 687.25

Ref: TR-I767517