CAS 136656-07-0

Timosaponina B II

Descrição:

Timosaponina B II é um composto de saponina derivado principalmente da espécie vegetal Timosaponin, que é conhecido por suas várias atividades biológicas. É caracterizado por sua complexa estrutura glicosídica, que geralmente inclui um aglicona esteroide ou triterpenoide ligada a um ou mais açúcares. Essa configuração estrutural contribui para suas propriedades surfactantes, permitindo que interaja com membranas biológicas. Timosaponina B II tem sido estudado por seus potenciais efeitos farmacológicos, incluindo atividades anti-inflamatórias, anticancerígenas e imunomoduladoras. Além disso, pode apresentar efeitos citotóxicos contra certas linhagens celulares cancerosas, tornando-se um assunto de interesse na química medicinal. O composto é solúvel em solventes orgânicos e pode ter solubilidade limitada em água, o que é comum para muitas saponinas. Seu perfil de segurança e potenciais aplicações terapêuticas continuam a ser explorados na pesquisa científica, destacando a importância dos produtos naturais na descoberta e desenvolvimento de medicamentos.

Fórmula: C₄₅H₇₆O₁₉

InChI: InChI=1/C45H76O19/c1-19(18-58-40-37(55)34(52)31(49)27(15-46)60-40)7-12-45(57)20(2)30-26(64-45)14-25-23-6-5-21-13-22(8-10-43(21,3)24(23)9-11-44(25,30)4)59-42-39(36(54)33(51)29(17-48)62-42)63-41-38(56)35(53)32(50)28(16-47)61-41/h19-42,46-57H,5-18H2,1-4H3/t19-,20-,21+,22-,23+,24-,25-,26-,27+,28+,29+,30-,31+,32+,33-,34-,35-,36-,37+,38+,39+,40+,41-,42+,43-,44-,45?/m0/s1

Chave InChI: InChIKey=SORUXVRKWOHYEO-UJDJZYEZSA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)[C@@H](O)[C@@H](CO)O5)CC4)[H])[H])[H])(C[C@]7([C@@]2([C@H](C)[C@](CC[C@@H](CO[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C)(O)O7)[H])[H])[H]

Sinónimos:

• (3β,5β,22α,25S)-26-(β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-<smallcap>D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-galactopyranoside
• 1H-Naphth[2′,1′:4,5]indeno[2,1-b]furan, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• 25S-Timosaponin B II
• Furostan, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• Prototimosaponin A III
• Timosaponin B2
• Timosaponin Bii
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (3β,5β,22α,25S)-26-(β-<smallcap>D</smallcap>-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-<smallcap>D</span>-glucopyranosyl-
• 1H-Naphth[2′,1′:4,5]indeno[2,1-b]furan, β-D-galactopyranoside deriv.
• (3β,5β,22α,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
• β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-
• Furostan, β-D-galactopyranoside deriv.
• timosaponin B-II
• Anemarsaponin BII, 98%, from Anemarrhena asphodeloides Bunge
• Timosaponin BII USP/EP/BP
• (25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol
• (25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol

β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-

CAS: 136656-07-0

Fórmula: C₄₅H₇₆O₁₉

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 921.0735

Ref: IN-DA00126J

Timosaponin BII

CAS: 136656-07-0

Timosaponin BII

Pureza: ≥98%

Peso molecular: 921.07g/mol

Ref: 54-BUP07152

Timosaponin BII

CAS: 136656-07-0

Fórmula: C₄₅H₇₆O₁₉

Peso molecular: 921.08

Ref: 7W-GY6130

Timosaponin BII

CAS: 136656-07-0

Timosaponin BII has anti-diabetes, antioxidant, anti-inflammatory, and anti-dementia activities, it can significantly reduce the neurotoxicity induced by beta amyloid peptide 25-35 in primary neurons, the mechanism of which may be related with resisting oxidative damage and regulating the cholinergic system.Timosaponin BII can improve the neurological symptoms of cerebral ischemic rat, reduce infarct size, relieve brain water edema, improve hemorheology, reduce inflammatory injury of cerebral ischemia; it could be used in the preparation of a medicament or product for the prevention and treatment of stroke.

Fórmula: C₄₅H₇₆O₁₉

Pureza: 95%~99%

Peso molecular: 921.084

Ref: BP-BP1396

Timosaponin BII

CAS: 136656-07-0

Timosaponin BII combats dementia, treats type 2 diabetes, has antioxidant properties, and reduces BACE1 with retinal benefits.

Fórmula: C₄₅H₇₆O₁₉

Pureza: 98% - >99.99%

Cor e Forma: Solid

Peso molecular: 921.07

Ref: TM-T3394

Timosaponin b ii

CAS: 136656-07-0

Natural glycoside

Fórmula: C₄₅H₇₆O₁₉

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 921.09

Ref: 5G-83272

Timosaponin B II

CAS: 136656-07-0

Timosaponin B II is a natural compound that inhibits the activity of cytochrome P450 enzymes. It has been shown to induce autophagy in a dopamine-dependent manner, which may be due to its ability to decrease mitochondrial membrane potential and increase phase transition temperature. Timosaponin B II also induces neurotrophic factors and matrix effects, which are beneficial for the treatment of inflammatory conditions, neurodegenerative diseases, and metabolic disorders. The drug has been shown to have pharmacokinetic properties that are similar to those of timosaponin I. The molecular weight of the molecule was determined by LC-MS/MS analysis as 527.2 amu. Timosaponin B II is not metabolized by cytochrome P450 enzymes or glucuronidases, but it is hydrolyzed by esterases or glutathione reductase.

Fórmula: C₄₅H₇₆O₁₉

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 921.07 g/mol

Ref: 3D-FT73829