CAS 136672-64-5

N-(5-Aminopentyl) methotrexate amide

CAS: 136672-64-5

N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.

Fórmula: C₂₅H₃₄N₁₀O₄

Pureza: Min. 95%

Cor e Forma: Yellow Powder

Peso molecular: 538.6 g/mol

Ref: 3D-FA17806

N-(5-Aminopentyl) Methotrexate Amide

Produto Controlado

CAS: 136672-64-5

Applications The 5-aminopentyl amide derivative of the folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.
References Fan, J. et al.: J. Biol. Chem., 266, 14862 (1991);

Fórmula: C₂₅H₃₄N₁₀O₄

Cor e Forma: Neat

Peso molecular: 538.6

Ref: TR-A619600