CAS 137234-62-9

Voriconazol

Descrição:

Voriconazol é um medicamento antifúngico usado principalmente para tratar infecções fúngicas graves, particularmente aquelas causadas por espécies de Aspergillus e Candida. Pertence à classe dos antifúngicos triazólicos, que funcionam inibindo a enzima lanosterol 14α-desmetilase, crucial para a síntese de ergosterol nas membranas celulares fúngicas. Voriconazol é caracterizado por sua atividade de amplo espectro contra vários fungos, tornando-o eficaz em infecções invasivas e não invasivas. O composto é tipicamente administrado por via oral ou intravenosa e é conhecido por sua boa biodisponibilidade e penetração nos tecidos. Sua farmacocinética pode ser influenciada por fatores como idade, função hepática e medicamentos concomitantes, exigindo monitoramento cuidadoso dos níveis do medicamento em alguns pacientes. Voriconazol também está associado a potenciais efeitos colaterais, incluindo distúrbios visuais, hepatotoxicidade e reações cutâneas. Devido ao seu mecanismo de ação específico e perfil de efeitos colaterais, Voriconazol é frequentemente reservado para casos em que outros tratamentos antifúngicos são ineficazes ou inadequados.

Fórmula: C₁₆H₁₄F₃N₅O

InChI: InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3

Chave InChI: InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N

SMILES: [C@@]([C@@H](C)C=1C(F)=CN=CN1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3

Sinónimos:

• (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
• (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate
• (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
• 2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
• 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
• 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,S*)]-
• Drg 0301
• G-573
• Uk 109496
• Vfend
• Voriconazol
• (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate
• Voriconazole
• UK-10949
• (2R,3S/2S,3R)-3-(5-FLUORO-4-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIA
• (aR,S)-a-(2,4-Difluorophenyl)-5-fluoro--methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

Voriconazole

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 349.32

Ref: 3B-V0116

Voriconazole

CAS: 137234-62-9

Cor e Forma: Neat

Ref: 61-FOR1094.00

Voriconazole 2.0 mg/ml in Methanol

CAS: 137234-62-9

Cor e Forma: Single Solution

Ref: 61-AMP1094.00-07

VORICONAZOLE CRS

CAS: 137234-62-9

VORICONAZOLE CRS

Fórmula: C₁₆H₁₄F₃N₅O

Cor e Forma: White. Powder.

Peso molecular: 349.3105

Ref: 41-Y0001395

Voriconazole

CAS: 137234-62-9

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Fórmula: C₁₆H₁₄F₃N₅O

Cor e Forma: White Powder

Peso molecular: 349.11504

Ref: 45-1718008

4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 349.3105

Ref: IN-DA0012YZ

Voriconazole

CAS: 137234-62-9

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: 98% - 99.91%

Cor e Forma: White To Off White Crystalline Powder

Peso molecular: 349.31

Ref: TM-T0120

Voriconazole

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Cor e Forma: White To Off-White Solid

Peso molecular: 349.32

Ref: 4Z-V-101

Voriconazole-d3

CAS: 137234-62-9

Fórmula: C₁₆H₁₁D₃F₃N₅O

Cor e Forma: White To Off-White Solid

Peso molecular: 352.34

Ref: 4Z-V-1027

Voriconazole

CAS: 137234-62-9

Voriconazole

Pureza: 98%

Peso molecular: 349.31g/mol

Ref: 54-PC109157

Voriconazole

CAS: 137234-62-9

Voriconazole

Pureza: ≥98%

Peso molecular: 349.31g/mol

Ref: 54-BUP17710

Voriconazole

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: 98.0 - 102.0 %

Cor e Forma: White to off-white crystalline powder

Peso molecular: 349.31

Ref: 7W-GA6306

Voriconazole

Produto Controlado

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Cor e Forma: Neat

Peso molecular: 349.31

Ref: 04-C17930000

Voriconazole

Produto Controlado

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Cor e Forma: Neat

Peso molecular: 349.31

Ref: 86-MM1094.00

Voriconazole Impurity 4

CAS: 137234-62-9

Fórmula: C₁₆H₁₃ClF₃N₅OHCl

Cor e Forma: White To Off-White Solid

Peso molecular: 383.76 36.46

Ref: 4Z-V-1017

Voriconazole-d6

CAS: 137234-62-9

Fórmula: C₁₆H₈D₆F₃N₅O

Peso molecular: 355.35

Ref: 4Z-V-1042

Voriconazole-13C-d3

CAS: 137234-62-9

Fórmula: C₁₅₁₃CH₁₁D₃F₃N₅O

Peso molecular: 353.33

Ref: 4Z-V-1044

Voriconazole RS

CAS: 137234-62-9

Cor e Forma: White Solid Crystalline Powder

Ref: 2K-1153700021

Voriconazole

CAS: 137234-62-9

Voriconazole is an antifungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. This agent also has anti-inflammatory effects and can be used to treat infections caused by Candida glabrata. Voriconazole binds to the cytoplasmic membrane, inhibiting sterol biosynthesis, which leads to cell death. It has been shown to be effective in treating infections caused by Cryptococcus neoformans and Aspergillus fumigatus and is currently being evaluated for its effectiveness against other opportunistic fungal infections such as histoplasmosis. Voriconazole is not active against bacterial or viral infections.

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 349.31 g/mol

Ref: 3D-FV29101

Voriconazole - Bio-X ™

CAS: 137234-62-9

Voriconazole is a synthetic, lipophilic molecule that is used in the treatment of fungal infections. Voriconazole binds to ergosterol which is the major sterol in the cell wall of fungi and inhibits its synthesis, leading to cell death. This drug binds to the enzyme 14α-demethylase allowing the conversion of lanosterol into ergosterol. As a result, this binding leads to the inhibition of ergosterol synthesis, as well as other sterols that are necessary for fungal growth (e.g., squalene).

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 349.31 g/mol

Ref: 3D-BV164532