CAS 137348-10-8

fator de hipercalcemia de malignidade*fragmento 107-1

Descrição:

A hipercalcemia de malignidade, especificamente o fragmento designado como 107-1, é um peptídeo associado à condição patológica de hipercalcemia, frequentemente observada em malignidades. Este fragmento é derivado de uma proteína maior que desempenha um papel no metabolismo do cálcio e está implicado na interrupção da homeostase normal do cálcio em pacientes com câncer. O número CAS 137348-10-8 identifica este fragmento específico, que se caracteriza por sua capacidade de influenciar a atividade osteoclástica, levando ao aumento da reabsorção óssea e níveis elevados de cálcio sérico. A estrutura e sequência do peptídeo contribuem para sua atividade biológica, tornando-o um assunto de interesse na pesquisa do câncer e possíveis intervenções terapêuticas. Seu papel na hipercalcemia relacionada à malignidade destaca a complexa interação entre a biologia tumoral e o metabolismo mineral, sublinhando a necessidade de mais estudos para elucidar seus mecanismos e aplicações potenciais em ambientes clínicos.

Fórmula: C₁₄₂H₂₂₈N₄₂O₅₈

InChI: InChI=1/C142H228N42O58/c1-58(2)33-73(143)113(213)162-77(28-30-104(210)241-105(211)49-157-116(216)89(50-185)161-97(198)47-156-134(234)108(66(15)193)183-135(235)107(63(11)12)180-98(199)48-155-117(217)90(51-186)174-126(226)86(41-101(204)205)171-121(221)81(36-61(7)8)168-123(223)83(38-70-44-153-75-24-20-19-23-72(70)75)166-112(212)64(13)159-129(229)91(52-187)175-118(218)76(25-21-31-151-141(146)147)164-133(233)106(145)65(14)192)115(215)154-46-96(197)160-85(40-100(202)203)125(225)170-84(39-71-45-150-57-158-71)124(224)169-82(37-62(9)10)122(222)176-93(54-189)131(231)173-88(43-103(208)209)128(228)181-109(67(16)194)136(236)178-94(55-190)132(232)182-111(69(18)196)138(238)184-110(68(17)195)137(237)179-95(56-191)140(240)242-139(239)79(26-22-32-152-142(148)149)165-130(230)92(53-188)177-127(227)87(42-102(206)207)172-120(220)80(35-60(5)6)167-119(219)78(27-29-99(200)201)163-114(214)74(144)34-59(3)4/h19-20,23-24,44-45,57-69,71,73-74,76-95,106-111,153,185-196H,21-22,25-43,46-56,143-145H2,1-18H3,(H,154,215)(H,155,217)(H,156,234)(H,157,216)(H,159,229)(H,160,197)(H,161,198)(H,162,213)(H,163,214)(H,164,233)(H,165,230)(H,166,212)(H,167,219)(H,168,223)(H,169,224)(H,170,225)(H,171,221)(H,172,220)(H,173,231)(H,174,226)(H,175,218)(H,176,222)(H,177,227)(H,178,236)(H,179,237)(H,180,199)(H,181,228)(H,182,232)(H,183,235)(H,184,238)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H4,146,147,151)(H4,148,149,152)/t64-,65+,66+,67+,68+,69+,71?,73-,74-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,106-,107-,108-,109-,110-,111-/m0/s1

Sinónimos:

• Parathyroid hormone-related protein-(107-139)
• Pthrp (107-139)
• L-Arginine, L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-alpha-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-alpha-glutamylglycyl-L-alpha-aspartyl-L-histidyl-L-leucyl-L-seryl-L-alpha-aspartyl-L-thronyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-seryl-
• Hypercalcemia Of Malignancy Factor (107-139) (Human)

Osteostatin (human)

CAS: 137348-10-8

The carboxyl-terminal fragment of pTHrP, TRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR, is a potent inhibitor of osteoclastic bone resorption. It is suggested that this product acts directly on osteoclasts.

Fórmula: C₁₄₂H₂₂₈N₄₂O₅₈

Cor e Forma: White Powder

Peso molecular: 3451.62

Ref: 01-4031194

Osteostatin (human) trifluoroacetate salt

CAS: 137348-10-8

Osteostatin is a recombinant human protein that inhibits bone growth by binding to and neutralizing the effect of forskolin. Osteostatin also has an inhibitory effect on cancer cells, as it inhibits mitochondrial pathways and prevents the activation of factor receptors. Osteostatin blocks the synthesis of cAMP, which is necessary for cell proliferation in cancer cells. The inhibition of cAMP levels leads to a decrease in the production of proteins that stimulate bone growth, such as runx2.

Fórmula: C₁₄₂H₂₂₈N₄₂O₅₈

Pureza: Min. 95%

Peso molecular: 3,451.58 g/mol

Ref: 3D-FO108927