CAS 137530-41-7

(+)-2'-Desoxi-3'-tio-5-fluorocitidina

Descrição:

(+)-2'-Desoxi-3'-tio-5-fluorocitidina, com o número CAS 137530-41-7, é um análogo de nucleosídeo sintético que incorpora enxofre e flúor em sua estrutura, modificando o nucleosídeo natural citidina. Este composto apresenta uma ligação tioéther na posição 3′ e um átomo de flúor na posição 5′, o que melhora sua estabilidade e altera sua atividade biológica. É estudado principalmente por suas potenciais propriedades antivirais e anticancerígenas, pois pode interferir na síntese de ácidos nucleicos. A presença do átomo de flúor pode aumentar a afinidade do composto por polimerases virais, tornando-o um candidato para aplicações terapêuticas contra certas infecções virais. Além disso, a modificação tioéther pode contribuir para sua resistência à degradação enzimática. O composto é tipicamente caracterizado por sua fórmula molecular, estereoquímica e interações específicas com alvos biológicos, que são cruciais para entender seu perfil farmacológico. No geral, (+)-2'-Desoxi-3'-tio-5-fluorocitidina representa uma área significativa de pesquisa em química medicinal e desenvolvimento de medicamentos.

Fórmula: C₈H₁₀FN₃O₃S

InChI: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1

Chave InChI: InChIKey=XQSPYNMVSIKCOC-RITPCOANSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)SC2)C=C(F)C(N)=N1

Sinónimos:

• (+)-2′-Deoxy-3′-thia-5-fluorocytidine
• (+)-Ftc
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
• 2',3',5-Ftc
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, rel-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, cis-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-cis)-
• 3'-Thia-2'.3'-dideoxy-5-fluorocytidine
• 4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
• 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
• 524W91
• Bw 524W91
• RCV
• Racivir

Emtricitabine Enantiomer (4-amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 5-Fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine)

CAS: 137530-41-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₈H₁₀FN₃O₃S

Cor e Forma: Off-White Solid

Peso molecular: 247.04269

Ref: 45-1A04620

ent-Emtricitabine

CAS: 137530-41-7

Fórmula: C₈H₁₀FN₃O₃S

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 247.2467

Ref: IN-DA0013HH

Emtricitabine Enantiomer

CAS: 137530-41-7

Fórmula: C₈H₁₀FN₃O₃S

Cor e Forma: White To Off-White Solid

Peso molecular: 247.24

Ref: 4Z-E-581

(+)-Emtricitabine

CAS: 137530-41-7

Ref: 7W-GC3631

Emtricitabine IP Impurity D

CAS: 137530-41-7

Fórmula: C₈H₁₀FN₃O₃S

Peso molecular: 247.25

Ref: ST-EA-CP-E5001

ent-Emtricitabine

Produto Controlado

CAS: 137530-41-7

Stability Hygroscopic
Applications A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References Mellors, J., et al.: Science, 72, 1167 (1996), Reimann, K., et al.: J. Virol., 79, 8878 (2005), Rose, J., et al.: J. Biol. Chem., 280, 7413 (2005), Acierno, P., et al.: J. Immunol., 176, 5338 (2006),

Fórmula: C₈H₁₀FN₃O₃S

Cor e Forma: Neat

Peso molecular: 247.25

Ref: TR-E525005

(+)-Emtricitabine

CAS: 137530-41-7

Emtricitabine is a synthetic nucleoside analog of cytidine. It is used in the treatment of HIV infection and hepatitis B virus infection. Emtricitabine binds to human DNA polymerase, preventing the incorporation of viral DNA into the host cell's genome. This prevents the virus from multiplying and reproducing, thereby inhibiting the spread of HIV in humans. The drug has been shown to inhibit replication at all stages of HIV-1, including reverse transcription and integration into host cell DNA. Emtricitabine also inhibits replication of other viruses such as herpes simplex virus type 1 (HSV-1) and hepatitis C virus (HCV). Emtricitabine is a prodrug that must be activated by phosphorylation before it can be incorporated into DNA. This activation requires tenofovir alafenamide hemifumarate as an activator, which is an experimental drug with improved bioavailability, reduced renal clearance, and

Fórmula: C₈H₁₀FN₃O₃S

Pureza: Min. 95%

Peso molecular: 247.25 g/mol

Ref: 3D-NE16704