CAS 137813-35-5

CICLO(ARG-GLY-ASP-D-PHE-VAL)

Descrição:

CICLO(ARG-GLY-ASP-D-PHE-VAL), com o número CAS 137813-35-5, é um peptídeo cíclico composto por cinco aminoácidos: arginina (Arg), glicina (Gly), ácido aspártico (Asp), D-fenilalanina (D-Phe) e valina (Val). A estrutura cíclica é formada pela ligação dos grupos amino e carboxila terminais, o que aumenta sua estabilidade em comparação com peptídeos lineares. Este composto exibe características típicas de peptídeos, como a capacidade de interagir com receptores biológicos e enzimas, tornando-o de interesse na pesquisa farmacêutica, particularmente no design e desenvolvimento de medicamentos. Sua sequência específica e natureza cíclica podem contribuir para atividades biológicas únicas, incluindo papéis potenciais na modulação de processos celulares ou servindo como um suporte para a entrega de medicamentos. Além disso, a presença de aminoácidos D, como D-Phe, pode influenciar a resistência do peptídeo à degradação enzimática, aumentando ainda mais seu potencial terapêutico. No geral, CICLO(ARG-GLY-ASP-D-PHE-VAL) representa um composto valioso no campo da química medicinal e da pesquisa de peptídeos.

Fórmula: C₂₆H₃₈N₈O₇

Sinónimos:

• Cyclo(Rgdd-Fv)
• Rgdfv Peptide, Cyclic

Cyclo(-Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.

Fórmula: C₂₆H₃₈N₈O₇

Pureza: 96.9%

Cor e Forma: White Lyophilisate

Peso molecular: 574.64

Ref: 01-4026200

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a peptide inhibitor of protein interactions. It binds to the ligand binding site of receptor and inhibits the activation of this receptor. Cyclo(Arg-Gly-Asp-D-Phe-Val) also binds to antibodies and can be used as a research tool for identifying antibody targets.

Fórmula: C₂₆H₃₈N₈O₇•CH₃COOH•2H₂O

Pureza: Min. 95%

Peso molecular: 670.91 g/mol

Ref: 3D-ICA-4304-V

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a cyclic peptide that inhibits the activity of surface glycoprotein enzymes. It has shown to be effective against malignant brain tumor cells and has anti-angiogenic effects. Cyclo(Arg-Gly-Asp-D-Phe-Val) also inhibits integrin receptor function by binding to the αVβ3 or αVβ5 integrin, which may be useful for biomarker identification. This compound is potent as an antagonist to epidermal growth factor (EGF), which may have potential use in treating benign prostatic hyperplasia.

Fórmula: C₂₆H₃₈N₈O₇

Pureza: Min. 95%

Peso molecular: 574.63 g/mol

Ref: 3D-ICA-4304

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt

CAS: 137813-35-5

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a basic fibroblast growth factor that has been shown to have proliferative effects on diabetic retinopathy and ocular neovascularization. It binds to integrin receptors on the surface of cells, which are involved in cell adhesion. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt also has antiangiogenic effects and blocks the angiogenesis process by inhibiting the production of epidermal growth factor (EGF). This drug may be useful for treating certain types of cancer such as malignant brain tumors or neuroblastomas, because it can cause neuronal death. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a cyclic peptide with a reactive amino acid side chain.

Fórmula: C₂₆H₃₈N₈O₇

Pureza: Min. 95%

Peso molecular: 574.63 g/mol

Ref: 3D-FC108714