CAS 138-14-7
:Mesilato de deferoxamina
Descrição:
Mesilato de deferoxamina é um agente quelante usado principalmente no tratamento de condições de sobrecarga de ferro, como aquelas resultantes de transfusões de sangue repetidas em pacientes com condições como talassemia ou doença falciforme. É um composto solúvel em água que forma complexos estáveis com íons férricos, facilitando sua excreção do corpo. A substância é derivada da bactéria *Streptomyces pilosus* e é caracterizada por sua capacidade de se ligar seletivamente ao ferro, reduzindo assim sua toxicidade e prevenindo danos aos órgãos. Mesilato de deferoxamina é tipicamente administrado por vias subcutâneas ou intravenosas, e sua farmacocinética envolve distribuição rápida e excreção renal. O composto é conhecido por seu perfil de toxicidade relativamente baixo, embora os efeitos colaterais potenciais possam incluir reações alérgicas, distúrbios gastrointestinais e efeitos na visão com o uso prolongado. Sua eficácia no manejo da sobrecarga de ferro o tornou um agente terapêutico crítico em ambientes de hematologia e oncologia.
Fórmula:C25H48N6O8·CH4O3S
InChI:InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
Chave InChI:InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N
SMILES:S(C)(=O)(=O)O.C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O
Sinónimos:- Ba 33112
- Butanediamide, N<sup>4</sup>-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N<sup>1</sup>-(5-aminopentyl)-N<sup>1</sup>-hydroxy-, methanesulfonate (1:1)
- Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
- DFX mesylate
- Deferoxamine B mesylate
- Deferoxamine Mesilate
- Deferoxamine methanesulfonate
- Deferrioxamine B methanesulfonate
- Deferrioxamine methanesulfonate
- Desferal
- Desferal mesylate
- Desferrioxamine B mesylate
- Desferrioxamine B methanesulfonate
- Desferrioxamine mesilate
- Desferrioxamine mesylate
- Desferrioxamine methanesulfonate
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
- NSC 644468
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)
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14 produtos.
Deferoxamine Mesylate
CAS:Fórmula:C25H48N6O8·CH4O3SPureza:>97.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:656.79Desferrioxamine mesilate
CAS:Desferrioxamine mesilateFórmula:C27H56N6O14S2Cor e Forma:Off-WhitePeso molecular:752.8953Deferoxamine Mesylate
CAS:Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugsFórmula:C25H48N6O8·CH4O3SCor e Forma:White PowderPeso molecular:656.34148Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Fórmula:C26H52N6O11SPureza:94.68% - 99.8%Cor e Forma:SolidPeso molecular:656.79Deferoxamine mesylate
CAS:Deferoxamine mesylateFórmula:C25H48N6O8·CH3SO3HPureza:By hplc: 99.0% by area (Typical Value in Batch COA)Cor e Forma: white solidPeso molecular:656.79g/molDesferrioxamine B mesylate
CAS:Fórmula:C25H48N6O8·CH4O3SPureza:≥ 98.0%Cor e Forma:White to almost white powderPeso molecular:656.79Deferoxamine Mesylate
CAS:Produto ControladoApplications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);Fórmula:C25H48N6O8·CH4O3SCor e Forma:Off-WhitePeso molecular:656.79Deferoxamine mesylate
CAS:Deferoxamine is a very well known drug for the treatment of iron excess occurring in patients with thalassemia who are receiving regular transfusions. Excessive iron intake from diet may also cause accumulation of the metal ions which result in several symptoms such as metabolic acidosis and hypovolemic shock. The mechanism of action of Deferoxamine is based on its ability to chelate iron and other metal ions (i.e. aluminum) permitting their rapid urinary elimination. Recently, another potential therapeutic uses of Deferoxamine for treating diabetic neuropathy was suggested since it was observed that the drug could activate the production of pro-angiogenic, neuroprotective and anti inflammatory factors. Read the full story here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011
Fórmula:C26H52N6O11SPureza:Min. 98.0 Area-%Peso molecular:656.79 g/molRef: 3D-D-0675
5gA consultar10gA consultar25gA consultar50gA consultar100gA consultar-Unit-ggA consultarDeferoxamine mesylate
CAS:Deferoxamine mesylate is an iron chelator that is used in the treatment of iron overload and to treat patients with chronic renal failure. Deferoxamine mesylate has been shown to inhibit angiogenesis by inhibiting the basic protein required for this process. It is also known to have a protective effect on myocardial cells, preventing cell death due to lack of oxygen (reactive oxygen species). Deferoxamine mesylate also inhibits neuronal death in a model system. Deferoxamine mesylate binds to DNA and inhibits RNA synthesis, which has led to its use as a fluorescence probe for the detection of DNA binding activity. The drug has also been shown to act as a metal chelate, binding with metals such as iron, copper, and zinc.Fórmula:C26H52N6O11SPureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:656.79 g/mol
