CAS 1380288-87-8

Pinometostat

Descrição:

Pinometostat é um inibidor de moléculas pequenas conhecido principalmente por seu papel em direcionar a enzima DOT1L (disruptor do silenciamento telomérico 1-like), que está envolvida na metilação da histona H3 na lisina 79. Este composto tem atraído atenção no campo da pesquisa do câncer, particularmente por suas potenciais aplicações terapêuticas no tratamento de leucemias agudas, especialmente aquelas associadas a rearranjos do gene MLL (leucemia de linhagem mista). Pinometostat exibe características típicas de uma terapia direcionada, visando interromper vias moleculares específicas que contribuem para a tumorigenese. Seu mecanismo de ação envolve inibir a metilação aberrante de histonas que promove a expressão de genes oncogênicos. O composto passou por várias avaliações pré-clínicas e clínicas para avaliar sua eficácia e perfil de segurança. Assim como muitos medicamentos em investigação, a pesquisa contínua é crucial para entender completamente sua farmacocinética, potenciais efeitos colaterais e seu potencial terapêutico geral em oncologia.

Fórmula: C₃₀H₄₂N₈O₃

InChI: InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1

Chave InChI: InChIKey=LXFOLMYKSYSZQS-LURJZOHASA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(C(C)C)[C@H]4C[C@@H](CCC=5NC=6C(N5)=CC=C(C(C)(C)C)C6)C4)[C@H]1O

Sinónimos:

• 9H-Purin-6-amine, 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
• 5′-Deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]adenosine
• Adenosine, 5′-deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-
• EPZ 5676
• Pinometostat
• EPZ 005676
• 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-diMethylethyl)-1H-benziMidazol-2-yl]ethyl]cyclobutyl](1-Methylethyl)aMino]-β-D-ribofuranosyl]-9H-purin-6-aMine
• (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
• 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H-purin-6-amine

(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-((((lr,3S)-3-(2-(5-(tert-butyl)-lH-benzo[d]imidazol2yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

CAS: 1380288-87-8

Fórmula: C₃₀H₄₂N₈O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 562.7063

Ref: IN-DA0039K9

Pinometostat

CAS: 1380288-87-8

Pinometostat

Pureza: ≥95%

Peso molecular: 562.71g/mol

Ref: 54-BUP16320

Pinometostat

CAS: 1380288-87-8

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.

Fórmula: C₃₀H₄₂N₈O₃

Pureza: 99.19% - 99.86%

Cor e Forma: Solid

Peso molecular: 562.71

Ref: TM-T3099

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H- purin-6-amine

CAS: 1380288-87-8

Nilotinib is a small molecule that inhibits the tyrosine kinase activity of TK1, TK2, and TK3. It binds to the ATP-binding site of these kinases and prevents the phosphorylation of the cellular substrate. Nilotinib has been shown to inhibit the proliferation of leukemia cells in vitro, as well as to have antiproliferative effects in vivo. Nilotinib can be used for the treatment of chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). In addition, it has been shown to have synergistic effects with other drugs such as α1-acid glycoprotein inhibitors or methyltransferase inhibitors. Nilotinib can also be used for cases of hepatic steatosis.

Fórmula: C₃₀H₄₂N₈O₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 562.71 g/mol

Ref: 3D-FD146242

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-{[(propan-2-yl)[(1r,3s)-3-[2-(6-tert-butyl-1H-1,3-benzodiazol-2-yl)ethyl]cyclobutyl]amino]methyl}oxolane-3,4-diol

CAS: 1380288-87-8

Pureza: 98%

Peso molecular: 562.719

Ref: 10-F979323

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine

Produto Controlado

CAS: 1380288-87-8

Applications 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine, can be used as an adenosine anticancer, and antibiotic analogues.
References Moukha-chafiq, O., et al.: American Chem. Soci., 146 (2013)

Fórmula: C₃₀H₄₂N₈O₃

Cor e Forma: Neat

Peso molecular: 562.706

Ref: TR-D232835