CAS 13803-65-1

Cloridrato de anidrotetraciclina

Descrição:

Cloridrato de anidrotetraciclina é um derivado da tetraciclina, um antibiótico de amplo espectro conhecido por sua capacidade de inibir a síntese de proteínas bacterianas. Este composto é caracterizado por sua estrutura cristalina e tipicamente é um pó amarelo a laranja. É solúvel em água e exibe um perfil de solubilidade dependente do pH, o que pode influenciar sua biodisponibilidade e eficácia terapêutica. Cloridrato de anidrotetraciclina mantém a estrutura central da tetraciclina, que inclui um sistema de anel naftaceno, contribuindo para suas propriedades antibacterianas. A forma de hidrocloreto melhora sua estabilidade e solubilidade em soluções aquosas. Este composto é utilizado principalmente na medicina veterinária e tem aplicações no tratamento de várias infecções bacterianas. Além disso, é importante notar que, assim como outras tetraciclinas, a anidrotetraciclina pode causar efeitos colaterais e pode interagir com outros medicamentos, exigindo consideração cuidadosa em seu uso clínico. Seu mecanismo de ação envolve a ligação à subunidade ribossômica 30S das bactérias, impedindo assim a tradução de mRNA em proteínas, o que é crucial para o crescimento e reprodução bacteriana.

Fórmula: C₂₂H₂₂N₂O₇·ClH

InChI: InChI=1S/C22H22N2O7.ClH/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28;/h4-6,11,16,25-27,31H,7H2,1-3H3,(H2,23,30);1H/t11-,16-,22-;/m0./s1

Chave InChI: InChIKey=XBSQEFHDCDFNJU-WPJNXPDPSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(CC=3C(C2=O)=C(O)C=4C(C3C)=CC=CC4O)[H].Cl

Sinónimos:

• (1S,4aS,12aS)-3-[amino(hydroxy)methylidene]-4a,6,7-trihydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,12,12a-octahydrotetracen-1-aminium
• (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-11,12a-dihydroxy-6-methyl-4a,12a-dihydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
• (2Z,4S,4aS,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-10,11,12a-trihydroxy-6-methyl-4a,12a-dihydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, (4S,4aS,12aS)-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, [4S-(4α,4aα,12aα)]-
• 4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide monohydrochloride, (4S-(4alpha,4aalpha,12aalpha))- Anhydrotetracycline hydrochloride
• monohydrochloride, (4S-(4alpha,4aalpha,12aalpha))-
• Anhydrotetracycline hydrochloride

Anhydrotetracycline hydrochloride

CAS: 13803-65-1

Anhydrotetracycline hydrochloride, 13803-65-1, is an antibiotic commonly used in gene expression systems in bacteria. Learn more at Thermo Fisher Scientific.

Fórmula: C₂₂H₂₂N₂O₇•HCl

Peso molecular: 462.88

Ref: 02-J66688

ANHYDROTETRACYCLINE HYDROCHLORIDE CRS

CAS: 13803-65-1

ANHYDROTETRACYCLINE HYDROCHLORIDE CRS

Fórmula: C₂₂H₂₃ClN₂O₆

Cor e Forma: Powder.

Peso molecular: 446.8808

Ref: 41-A1200000

Anhydrotetracycline Hydrochloride ((4S ,4aS ,12aS )-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide monohydrochloride)

CAS: 13803-65-1

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Fórmula: C₂₂H₂₂N₂O₇·HCl

Cor e Forma: Yellow Solid

Peso molecular: 462.11938

Ref: 45-1035708

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)-

CAS: 13803-65-1

Fórmula: C₂₂H₂₃ClN₂O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 462.8802

Ref: IN-DA0017VE

Anhydrotetracycline hydrochloride

CAS: 13803-65-1

Anhydrotetracycline hydrochloride

Pureza: ≥98%

Peso molecular: 462.88g/mol

Ref: 54-BUP00621

Anhydrotetracycline hydrochloride

CAS: 13803-65-1

Anhydrotetracycline (hydrochloride) is a potent competitive inhibitor of broad-spectrum tetracycline destructase enzymes.

Fórmula: C₂₂H₂₃ClN₂O₇

Pureza: 98% - 98.90%

Cor e Forma: Solid

Peso molecular: 462.88

Ref: TM-T21508

Anhydrotetracycline Hydrochloride

Produto Controlado

CAS: 13803-65-1

Fórmula: C₂₂H₂₂N₂O₇·HCl

Cor e Forma: Yellow

Peso molecular: 462.88

Ref: 04-C10258000

(4S,4aS,12aS)-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide Hydrochloride (Anhydrotetracycline Hydrochloride)

CAS: 13803-65-1

Cor e Forma: Neat

Ref: 86-MM0452.03

Anhydrotetracycline hydrochloride

CAS: 13803-65-1

Fórmula: C₂₂H₂₂N₂O₇·HCl

Pureza: ≥ 98.0%

Cor e Forma: Yellow solid

Peso molecular: 462.88

Ref: 7W-GW9602

Anhydrotetracycline Hydrochloride

Produto Controlado

CAS: 13803-65-1

Impurity Tetracycline EP Impurity C Hydrochloride
Stability Hygroscopic
Applications Anhydrotetracycline is a tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems. It is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR systems, binding the Tet(R).
References Sokoloski, T., et al.: J. Pharm. Sci., 66, 1159 (1977), Paemen, L., et al.: Biochem. Pharmacol., 5, 105 (1996); A. Kamionka, et al.; Nucleic Acids Res. 32, 842 (2004) | M. Resch, et al.; Nucleic Acids Res. 36, 4390 (2008)

Fórmula: C₂₂H₂₂N₂O₇·HCl

Cor e Forma: Yellow

Peso molecular: 462.88

Ref: TR-A656050

Anhydrotetracycline hydrochloride

CAS: 13803-65-1

Anhydrotetracycline hydrochloride is a synthetic tetracycline antibiotic that has been shown to be active against methicillin-resistant strains of Staphylococcus aureus and Enterobacteriaceae. It is also effective against Gram-positive bacteria such as Streptococcus pneumoniae, Enterococcus faecalis, and Listeria monocytogenes. Anhydrotetracycline hydrochloride functions by inhibiting protein synthesis, which prevents the production of proteins vital for cell division. This antibiotic inhibits translation by interfering with the binding of aminoacyl-tRNA to ribosomes through an unknown mechanism. Anhydrotetracycline hydrochloride has also been shown to enhance bacterial growth in the presence of carbon sources such as butanol or sugar alcohols.

Fórmula: C₂₂H₂₃ClN₂O₇

Pureza: Min. 95 Area-%

Cor e Forma: Yellow Powder

Peso molecular: 462.88 g/mol

Ref: 3D-FA17930