CAS 138068-37-8

Lepirudina

Descrição:

Lepirudina é um anticoagulante sintético derivado da saliva da sanguessuga medicinal, Hirudo medicinalis. Funciona como um inibidor direto da trombina, o que significa que se liga à trombina e impede que ela converta o fibrinogênio em fibrina, inibindo assim a formação de coágulos sanguíneos. Lepirudina é utilizado principalmente em ambientes clínicos para o tratamento de pacientes com trombocitopenia induzida por heparina (HIT), uma condição em que a terapia com heparina leva a uma diminuição na contagem de plaquetas e a um aumento do risco de trombose. A substância é caracterizada por sua alta especificidade para a trombina, tornando-a eficaz no manejo de distúrbios trombóticos. Lepirudina é administrado por injeção intravenosa, e sua farmacocinética inclui uma meia-vida relativamente curta, necessitando de monitoramento cuidadoso dos níveis de anticoagulação nos pacientes. Efeitos adversos podem incluir complicações hemorrágicas, que são comuns com anticoagulantes, e reações de hipersensibilidade. No geral, Lepirudina representa uma opção terapêutica crítica na gestão da anticoagulação, particularmente para pacientes com contraindicações a anticoagulantes tradicionais como a heparina.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

InChI: InChI=1/C287H446N80O111S6/c1-24-132(17)225(359-272(462)187(122-483)350-242(432)147(41-30-33-81-289)322-258(448)170(95-197(297)384)317-206(393)108-303-233(423)148(54-67-192(292)379)313-202(389)107-310-240(430)183(118-479)355-278(468)223(130(13)14)357-265(455)174(99-201(301)388)342-266(456)180(115-369)319-208(395)110-304-235(425)150(60-73-212(400)401)323-269(459)184(119-480)352-254(444)165(90-129(11)12)335-270(460)185(120-481)353-253(443)164(89-128(9)10)334-260(450)172(97-199(299)386)340-244(434)151(55-68-193(293)380)315-204(391)106-309-239(429)179(114-368)348-249(439)158(65-78-217(410)411)330-281(471)229(136(21)374)363-273(463)188(123-484)354-263(453)178(103-222(420)421)347-283(473)230(137(22)375)362-264(454)168(93-141-48-52-144(378)53-49-141)346-282(472)228(135(20)373)361-232(422)145(291)86-125(3)4)280(470)345-162(87-126(5)6)236(426)306-111-209(396)320-181(116-370)267(457)344-176(101-220(416)417)238(428)307-105-203(390)316-152(61-74-213(402)403)243(433)321-146(40-29-32-80-288)241(431)339-171(96-198(298)385)259(449)326-153(56-69-194(294)381)250(440)351-186(121-482)271(461)358-224(131(15)16)279(469)364-227(134(19)372)277(467)311-112-205(392)314-149(59-72-211(398)399)234(424)305-113-210(397)356-231(138(23)376)286(476)367-85-37-45-191(367)276(466)331-160(42-31-34-82-290)284(474)365-83-35-43-189(365)274(464)328-154(57-70-195(295)382)248(438)349-182(117-371)268(458)338-169(94-142-104-302-124-312-142)257(447)341-173(98-200(300)387)261(451)343-175(100-219(414)415)237(427)308-109-207(394)318-177(102-221(418)419)262(452)337-166(91-139-38-27-26-28-39-139)255(445)327-155(62-75-214(404)405)245(435)325-159(66-79-218(412)413)251(441)360-226(133(18)25-2)285(475)366-84-36-44-190(366)275(465)329-157(64-77-216(408)409)246(436)324-156(63-76-215(406)407)247(437)336-167(92-140-46-50-143(377)51-47-140)256(446)333-163(88-127(7)8)252(442)332-161(287(477)478)58-71-196(296)383/h26-28,38-39,46-53,104,124-138,145-191,223-231,368-378,479-484H,24-25,29-37,40-45,54-103,105-123,288-291H2,1-23H3,(H2,292,379)(H2,293,380)(H2,294,381)(H2,295,382)(H2,296,383)(H2,297,384)(H2,298,385)(H2,299,386)(H2,300,387)(H2,301,388)(H,302,312)(H,303,423)(H,304,425)(H,305,424)(H,306,426)(H,307,428)(H,308,427)(H,309,429)(H,310,430)(H,311,467)(H,313,389)(H,314,392)(H,315,391)(H,316,390)(H,317,393)(H,318,394)(H,319,395)(H,320,396)(H,321,433)(H,322,448)(H,323,459)(H,324,436)(H,325,435)(H,326,449)(H,327,445)(H,328,464)(H,329,465)(H,330,471)(H,331,466)(H,332,442)(H,333,446)(H,334,450)(H,335,460)(H,336,437)(H,337,452)(H,338,458)(H,339,431)(H,340,434)(H,341,447)(H,342,456)(H,343,451)(H,344,457)(H,345,470)(H,346,472)(H,347,473)(H,348,439)(H,349,438)(H,350,432)(H,351,440)(H,352,444)(H,353,443)(H,354,453)(H,355,468)(H,356,397)(H,357,455)(H,358,461)(H,359,462)(H,360,441)(H,361,422)(H,362,454)(H,363,463)(H,364,469)(H,398,399)(H,400,401)(H,402,403)(H,404,405)(H,406,407)(H,408,409)(H,410,411)(H,412,413)(H,414,415)(H,416,417)(H,418,419)(H,420,421)(H,477,478)/t132-,133-,134+,135+,136+,137+,138+,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,223-,224-,225-,226-,227-,228-,229-,230-,231-/m0/s1

Sinónimos:

• Lepirudin Recombinant

Lepirudin

CAS: 138068-37-8

Synthetic peptide. Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Pureza: 95.2%

Cor e Forma: White Lyophilisate

Peso molecular: 6979.52

Ref: 01-4048773

Lepirudin acetate salt

CAS: 138068-37-8

Lepirudin acetate salt is a recombinant heparin that inhibits the activity of thrombin, an enzyme that converts fibrinogen to fibrin. Lepirudin acetate salt binds to thrombin and prevents it from binding to its target sites on the fibrinogen molecule. It is used as an anticoagulant in patients with heparin-induced thrombocytopenia. Lepirudin acetate salt has been shown to be effective against hirudin and lepirudin, which are inhibitors of heparins. The drug also inhibits the formation of polymerase chain reaction products by human polymorphonuclear leukocytes in vitro.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Pureza: Min. 95%

Peso molecular: 6,979.43 g/mol

Ref: 3D-FL109904

Lepirudin

CAS: 138068-37-8

Lepirudin is a drug used to treat thrombosis and pulmonary embolism. It inhibits the function of thrombin by binding to its active site and preventing it from converting fibrinogen into fibrin. Lepirudin is an inhibitor molecule that binds to human polymorphonuclear leukocytes, which are cells that contain large quantities of protein. The rate constant for the reaction between these two molecules was determined using chromatographic analysis. Lepirudin has been shown to be toxic in animal studies, leading to allergic symptoms such as rash, fever, chills, nausea, and vomiting. These reactions were reduced when given orally as a prodrug.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Pureza: Min. 95%

Peso molecular: 6,979.43 g/mol

Ref: 3D-FL168419