CAS 13870-90-1

Coenzima B12

Descrição:

Coenzima B12, também conhecido como metilcobalamina, é um cofator vital em vários processos bioquímicos, particularmente no metabolismo da homocisteína e na síntese de metionina. É uma vitamina solúvel em água que pertence ao complexo de vitaminas B, especificamente ao grupo B12, que inclui várias formas de cobalamina. Caracterizado por sua estrutura complexa, Coenzima B12 contém um íon de cobalto em seu núcleo, coordenado a um anel de corrina, e é distinguido pela presença de um grupo metila. Este composto desempenha um papel crucial no metabolismo celular, particularmente no sistema nervoso central e na formação de glóbulos vermelhos. A deficiência de Coenzima B12 pode levar a problemas de saúde significativos, incluindo anemia e distúrbios neurológicos. É obtido principalmente através de fontes dietéticas, particularmente produtos de origem animal, e é essencial para manter uma função neurológica adequada e a síntese de DNA. Além disso, Coenzima B12 é frequentemente utilizado em ambientes clínicos para tratar deficiências e condições de saúde relacionadas.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

InChI: InChI=1/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2

Chave InChI: InChIKey=OAJLVMGLJZXSGX-RQKYJTTQSA-L

SMILES: [CH2-]([Co+3]1234[N]=5[C@@]6(C)[C@@]7([N-]1C([C@@](C)([C@H]7CC(N)=O)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@H]8C(O)([C@@H](N9C=[N]2C=%10C9=CC(C)=C(C)C%10)O[C@@H]8CO)[H])=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5[C@@H](CCC(N)=O)[C@@]6(CC(N)=O)C)[C@](CC(N)=O)(C)[C@@H]%12CCC(N)=O)C(C)(C)[C@@H]%11CCC(N)=O)[H])[C@H]%13O[C@H]([C@H](O)[C@@H]%13O)N%14C=%15C(N=C%14)=C(N)N=CN%15

Sinónimos:

• (5'-Deoxy-5'-adenosyl)cobamide coenzyme
• (5,6-Dimethylbenzimidazolyl)Cobamide Coenzyme
• 5'-Deoxy-5'-adenosylcobalamin
• 5'-Deoxyadenosyl vitamin B12
• 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
• 5'-Deoxyadenosylcobalamin
• 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
• 5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
• 5′-Deoxyadenosyl vitamin B₁₂
• Actimide
• Adenosyl B12
• Adenosyl B₁₂
• Adenosylcobalamin
• Anabasi
• Betarin
• Calomide
• Cobalamin coenzyme
• Cobalamin, Co-(5'-deoxy-5'-adenosyl)-
• Cobalion
• Cobamamid
• Cobamamida
• Cobamamide
• Cobamide coenzyme, (5'-deoxy-5'-adenosyl)-
• Cobamide coenzyme, (5,6-dimethyl-1H-benzimidazolyl)-
• Cobamide, Co-(5'-deoxy-5'-adenosyl)-α-(5,6-dimethyl-1H-benzimidazolyl)-
• Cobanzyme
• Cobatlamin S
• Cobazymase
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') derivative hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Coenzile
• Coenzyme B12
• Coenzyme B₁₂
• DBC
• DBC coenzyme
• Dbcc
• Deoxyadenosylcobalamin
• Dibencozide
• Dibenzcozamide
• Dimebenzcozamide
• Dolonevran
• Enzicoba
• Funacomide
• Heraclene
• Hi-Fresmin
• Hycobal
• Indusil
• Lm 176
• Represil
• Sabalamin
• Vitamin B12 coenzyme
• Vitamin B12, Co-(5'-deoxy-5'-adenosyl) deriv.
• Vitamin B₁₂ coenzyme
• Vitamin B₁₂, Co-(5′-deoxy-5′-adenosyl) deriv.
• Xobaline
• α-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
• α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
• coenzyme B12 crystalline
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• adenosyl cobalamine
• 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• DMBC COENZYME
• CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
• ADENOSYLCOBALAMINE(COENZYME B12)(P)
• cobalaminecoenzyme
• Coenzyme B
• 2
• ADENOSYLCOBALAMINE(COENZYME B12)(RG)
• 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
• Cobamamide/VitaminB12
• Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• 5’-deoxyadenosylvitaminb12
• COBAMIDE
• COBAMAMIDE/DIBENCOZIDE
• DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
• COBAMAMIDE (PYROGEN FREE)
• cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
• ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
• lm176
• ADENOSYLCOBALAMINE(COENZYME B12)(AS)
• 1
• dbccoenzyme
• COENZYME B12, >=97.0%

Adenosylcobalamin

CAS: 13870-90-1

AdoCbl is an active form of vitamin B12, a corrinoid, and cofactor for enzymes like methylmalonyl CoA mutase. Produced by select bacteria/archaea.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: 95.29% - 99.46%

Cor e Forma: Solid

Peso molecular: 1579.58

Ref: TM-T14128

Coenzyme B12

CAS: 13870-90-1

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: (HPLC) 98.0 - 102.0 % (dried basis)

Cor e Forma: Dark red powder or crystalline powder

Peso molecular: 1579.58

Ref: 7W-GP8985

Cobamamide (Dibencozide, Coenzyme B12)

CAS: 13870-90-1

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Cor e Forma: Red Solid

Peso molecular: 1579.66

Ref: 4Z-C-161001

Cobamamide

Produto Controlado

CAS: 13870-90-1

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Cor e Forma: Neat

Peso molecular: 1579.58

Ref: 04-C11692190

Cobamamide

Produto Controlado

CAS: 13870-90-1

Applications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Cor e Forma: Neat

Peso molecular: 1579.58

Ref: TR-C633130

Coenzyme B12

CAS: 13870-90-1

Coenzyme B12, also known as vitamin B12, is a coenzyme that participates in the metabolism of amino acids and fatty acids. It is required for the conversion of homocysteine to methionine, which is an important step in the synthesis of S-adenosylmethionine (SAM), a major methyl donor. Coenzymes are required for many different reactions in cells, but they are not consumed during these reactions. Instead, they are regenerated and reused. Coenzyme B12 is synthesized by bacteria and archaea but not by animals. The cobalamin form of this coenzyme is made from cobaltous chloride or cobaltous sulfate and cyanide. This coenzyme has been shown to bind to riboswitches in bacteria and to ATP-binding cassette transporters in humans. Coenzyme B12 can exist in two different forms: adenosylcobalamin and methylcobalamin.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: Min. 97 Area-%

Cor e Forma: Powder

Peso molecular: 1,579.58 g/mol

Ref: 3D-FD65841

Cobamamide mono-Ribose13C5

Produto Controlado

CAS: 13870-90-1

Applications Isotope labelled Cobamamide (C633130) is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Fórmula: C₅C₆₇H₉₉CoN₁₈O₁₇P

Cor e Forma: Neat

Peso molecular: 1583.537

Ref: TR-C633132

Coenzyme B12

CAS: 13870-90-1

Coenzyme B12 is a versatile building block in the production of other fine chemicals. It is an important reaction component in research and development, and can also be used as a speciality chemical. Coenzyme B12 has high quality and is used as a reagent in the synthesis of organic compounds.

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Pureza: Min. 96.0 Area-%

Peso molecular: 1,579.58 g/mol

Ref: 3D-W-108227

Cobamamide (5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide)

CAS: 13870-90-1

Vitamin b12 (cyanocobalamin and related compounds with vitamin b12 activity) and its derivatives

Fórmula: C₇₂H₁₀₀CoN₁₈O₁₇P

Cor e Forma: Powder

Peso molecular: 1578.65834

Ref: 45-1142195

Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3)

CAS: 13870-90-1

Fórmula: C₇₂H₉₉CoN₁₈O₁₇P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1578.5738

Ref: IN-DA01CB8H