CAS 1393-48-2

Tiostreptona

Descrição:

Tiostreptona é um antibiótico tiopéptido que ocorre naturalmente, produzido principalmente pela bactéria *Streptomyces azureus*. É caracterizado por sua estrutura complexa, que inclui um núcleo bicíclico único e múltiplos grupos contendo enxofre, contribuindo para sua atividade biológica. Tiostreptona exibe potentes propriedades antimicrobianas, particularmente contra bactérias Gram-positivas, e tem sido estudado por suas potenciais aplicações no tratamento de várias infecções. O composto funciona inibindo a síntese de proteínas, direcionando-se especificamente ao RNA ribossômico, o que interrompe o processo de tradução nas células bacterianas. Além de seus efeitos antibacterianos, Tiostreptona mostrou promessas na pesquisa do câncer devido à sua capacidade de interferir nas vias de sinalização celular. Geralmente, é administrado em um ambiente de laboratório, e seu uso é restrito principalmente a fins de pesquisa. Precauções de segurança são necessárias ao manusear Tiostreptona, assim como com muitos antibióticos, para prevenir o desenvolvimento de resistência e garantir resultados terapêuticos eficazes. No geral, Tiostreptona representa um composto significativo no campo da microbiologia e da química medicinal.

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

InChI: InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-/t26-,30-,31-,32-,33+,34+,35+,39+,45+,47-,48-,49-,51-,52+,53+,71+,72+/m0/s1

Chave InChI: InChIKey=NSFFHOGKXHRQEW-AIHSUZKVSA-N

SMILES: O=C1N[C@]23[C@@](C=4N=C(SC4)[C@@](NC(=O)C=5N=C(SC5)[C@]([C@]([C@@H](C)O)(C)O)(NC(=O)[C@@]6(N=C(\C(=C\C)\NC(=O)[C@]([C@@H](C)O)(NC(=O)C=7N=C2SC7)[H])SC6)[H])[H])([C@@H](C)OC(=O)C=8N=C9C(=C([C@H](C)O)C8)C=C[C@]([C@@H]9O)(N[C@@]([C@H](CC)C)(C(=O)N[C@@H](C)C(=O)NC(=C)C(=O)N[C@H]1C)[H])[H])[H])(N=C(CC3)C%10=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS%10)[H]

Sinónimos:

• Alaninamide, <span class="text-smallcaps">L</smallcap>-threonyl-(4S)-2-[(1Z)-1-amino-1-propenyl]-4,5-dihydro-4-thiazolecarbonyl-2-[(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl]-4-thiazolecarbonyl-2-[(5R,6S)-6-[2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-thiazolyl]-5-[[N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</smallcap>-alanyl-2,3-didehydroalanyl-<smallcap>L</span>-alanyl]amino]-5-(4-carboxy-2-thiazolyl)-3,4,5,6-tetrahydro-2-pyridinyl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (1′→4)-lactone, (4→1)-lactam
• Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-<span class="text-smallcaps">L</smallcap>-isoleucyl-<smallcap>L</smallcap>-alanyl-2,3-didehydroalanyl-<smallcap>L</span>-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (1→5²⁸)-lactone
• Bryamycin
• Gargon
• N-{3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl}-2-[(11E)-37-(butan-2-yl)-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecaazanonacyclo[23.23.9.3~29,35~.1~2,5~.1~12,15~.1~19,22~.1~54,57~.0~1,53~.0~32,60~]tetrahexaconta-2(64),4,12(63),19(62),21,29,31,33,51,54,57,60-dodecaen-51-yl]-1,3-thiazole-4-carboxamide (non-preferred name)
• NSC 170365
• NSC 81722
• Thiactin
• Thiostrepton
• Thiostrepton A
• Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (1→528)-lactone

Thiostrepton, Streptomyces laurentii, 90+%

CAS: 1393-48-2

Natural cyclic oligopeptide antibiotic

Fórmula: C₇₂H₈₅O₁₈N₁₉S₅

Pureza: 90+%

Cor e Forma: Powder

Peso molecular: 1664.89

Ref: 02-J62332

Thiostrepton

CAS: 1393-48-2

Antibiotics nesoi

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Cor e Forma: White Powder

Peso molecular: 1663.49235

Ref: 45-1663700

Thiostrepton

CAS: 1393-48-2

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1664.8868

Ref: IN-DA006XMY

Thiostrepton from Streptomyces azureus

CAS: 1393-48-2

Thiostrepton from Streptomyces azureus

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: By hplc: 98.42% (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 1,664.89g/mol

Ref: 54-BIT1003

Thiostrepton

CAS: 1393-48-2

Fórmula: C₇₂H₈₅O₁₈N₁₉S₅

Pureza: ≥ 98.0%

Cor e Forma: White to pale yellow powder

Peso molecular: 1664.89

Ref: 7W-GA3924

Thiostrepton

CAS: 1393-48-2

Thiostrepton is a cyclic peptide from Streptomyces, active against gram-positive bacteria, used in veterinary medicine for mastitis and skin issues.

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: 98.09% - 99.57%

Cor e Forma: Solid

Peso molecular: 1664.89

Ref: TM-T1679

Thiostrepton

Produto Controlado

CAS: 1393-48-2

Stability Hygroscopic
Applications Natural antibiotic derived from Streptomyces.
References Starosta, A., et al.; Chem. Biol., 16, 1087 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Kwok, J., et al.: Mol. Cancer Res., 8, 24 (2010),

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Cor e Forma: Neat

Peso molecular: 1664.89

Ref: TR-T375150

Thiostrepton

CAS: 1393-48-2

Thiostrepton is a thiopeptide antibiotic with action on bacterial protein synthesis by binding to the ribosome and is used for treating bacterial infections in veterinary medicine and research applications.

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: Min. 95%

Cor e Forma: White To Light (Or Pale) Yellow Solid

Peso molecular: 1,664.89 g/mol

Ref: 3D-FT28240