CAS 139893-43-9
:Sal de amônio de sinvastatina
Descrição:
Sal de amônio de sinvastatina é um derivado da simvastatina, um medicamento amplamente utilizado para reduzir o colesterol que pertence à classe das estatinas. Este composto é caracterizado por sua capacidade de inibir a HMG-CoA redutase, uma enzima crucial para a biossíntese de colesterol no fígado. Como sal de amônio, geralmente apresenta melhor solubilidade em ambientes aquosos em comparação com seu composto original, o que pode melhorar sua biodisponibilidade e eficácia terapêutica. A estrutura molecular inclui um anel de lactona, que é essencial para sua atividade biológica, e a presença de um grupo de amônio contribui para sua natureza iônica. Sal de amônio de sinvastatina é frequentemente utilizado em formulações farmacêuticas, e sua estabilidade, solubilidade e propriedades farmacocinéticas são críticas para sua eficácia no manejo da hiperlipidemia. Além disso, pode apresentar efeitos colaterais comuns às estatinas, como dor muscular ou alterações nas enzimas hepáticas, necessitando de monitoramento durante o tratamento. No geral, Sal de amônio de sinvastatina representa um composto importante na gestão da saúde cardiovascular.
Fórmula:C25H40O6·H3N
InChI:InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);1H3/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
Chave InChI:InChIKey=FFPDWNBTEIXJJF-OKDJMAGBSA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@H](C[C@H](CC(O)=O)O)O)=C[C@H](C)C1)[H].N
Sinónimos:- (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate ammonium salt
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt (1:1), (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, [1S-[1α(βS*,δS*),2α,6β,8β,8aα]]-
- Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyheptanoate
- Ammonium simvastatin
- Simvastatin Ammouium Salt
- Simvastatin Hydroxy Acid, Ammonium Salt
- Simvastatin acid ammonium salt
- Simvastatin carboxylic acid ammonium salt
- Simvastatin hydroxyl acid ammonium salt
- Simvastatin impurity A
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Pureza (%)
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100
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50
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90
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95
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100
13 produtos.
Ammonium Tenivastatin ((3R,5R)-7-{((1S,2S,6R,8S,8aR)-8-[(2,2)-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid Ammonium Salt)
CAS:Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoiFórmula:C25H43NO6Cor e Forma:Off-White PowderPeso molecular:453.30904Simvastatin Hydroxy Acid (ammonium salt)
CAS:Fórmula:C25H43NO6Pureza:95%Cor e Forma:SolidPeso molecular:453.6120Simvastatin ammonium salt
CAS:Fórmula:C25H41NO5Pureza:≥ 95.0%Cor e Forma:White to light yellow, beige or light brown powderPeso molecular:435.60Simvastatin EP Impurity A Ammonium Salt (Simvastatin Acid Ammonium Salt, Tenivastatin Ammonium Salt)
CAS:Fórmula:C25H39O6·NH4Cor e Forma:Off-White SolidPeso molecular:435.58 18.04(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Ammonium Salt (Tenivastatin Ammonium Salt)
CAS:Produto ControladoFórmula:C25H39O6·H4NCor e Forma:NeatPeso molecular:453.61Simvastatin Hydroxy Acid Ammonium Salt
CAS:Applications A metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),Fórmula:C25H43NO6Cor e Forma:NeatPeso molecular:453.61Simvastatin-d6 Hydroxy Acid Ammonium Salt
CAS:Produto ControladoApplications A deuterated metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),Fórmula:C25H37D6NO6Cor e Forma:White To Light Orange ColourPeso molecular:459.65Simvastatin acid ammonium
CAS:Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.Fórmula:C25H43NO6Pureza:98.3%Cor e Forma:SolidPeso molecular:453.61Simvastatin hydroxy acid ammonium salt
CAS:Simvastatin is a hydrated, acylated statin that is used as a lipid-lowering drug. It inhibits HMG-CoA reductase, an enzyme that plays a central role in cholesterol biosynthesis. The reaction solution can be activated by mixing with an acyltransferase and the desired acyl group. Simvastatin has a toxicity profile that includes myopathy, rhabdomyolysis, and liver failure. Simvastatin also inhibits lipoprotein lipase and prevents the hydrolysis of triglycerides to fatty acids and glycerol. This leads to reduced levels of low-density lipoproteins (LDLs) and increased levels of high-density lipoproteins (HDLs). Simvastatin is converted into an amide form by enzymatic cleavage, which may lead to metabolic inhibition.Fórmula:C25H43NO6Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:453.61 g/mol
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