CAS 1405-20-5

polimixina B

Descrição:

polimixina B é um antibiótico polipeptídico cíclico usado principalmente para tratar infecções causadas por bactérias Gram-negativas. É derivado da bactéria Bacillus polymyxa e exibe uma estrutura única caracterizada por uma cauda hidrofóbica e um anel peptídico carregado positivamente, o que lhe permite interromper as membranas celulares bacterianas. Essa interrupção leva a um aumento da permeabilidade e, em última instância, à lise celular, tornando-o eficaz contra uma variedade de patógenos, incluindo Pseudomonas aeruginosa e Escherichia coli. polimixina B é frequentemente utilizado em formulações tópicas devido à sua nefrotoxicidade e neurotoxicidade quando administrado sistemicamente. É comumente encontrado em pomadas, colírios e outras preparações tópicas. Além disso, polimixina B ganhou atenção no contexto da resistência a antibióticos, pois às vezes é usado como tratamento de última linha para infecções multirresistentes. Seu uso, no entanto, é limitado por potenciais efeitos colaterais e o surgimento de cepas bacterianas resistentes, exigindo consideração cuidadosa nas aplicações clínicas.

Fórmula: C₅₆H₁₀₀N₁₆O₁₇S

InChI: InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

SMILES: CC(C)CC1C(=NC(CCN)C(=NC(CCN)C(=NC(CCO)C(=NCCC(C(=NC(CCN)C(=NC(Cc2ccccc2)C(=N1)O)O)O)N=C(C(CCN)N=C(C(CCO)N=C(C(CCN)N=CO)O)O)O)O)O)O)O.OS(=O)(=O)O

Sinónimos:

• Aerosporin
• Mastimyxin
• N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid
• N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt)
• Polymixin B Sulfate
• Polymyxin B (PMB)
• Polymyxin B 2,5-SULFATE
• Polymyxin B Sulphate
• Polymyxin B sulfate salt
• Polymyxin B, Sulfat (Salz)
• Polymyxin B₁-polymyxin B₂ sulfate
• polimixina B, sulfato (sal)
• polymyxin B sulfate
• polymyxine B, sulfate (sel)
• Polimixin B Sulphate
• APPLISORB
• MYP SUPPLEMENT
• LISTERIA MONOCYTOGENES SELECTIVE SUPPLEMENT I
• POLYMYXIN B SULFATE, BACILLUS POLYMYXA
• POLYMIXIN B SULPHATE
• Polymyxin B solution
• LISTERIA MONO SELECTIVE SUPPLEMENT I
• POLYMYXIN B
• polymyxin B standard solution
• BACILLUS CEREUS SELECTIVE SUPPLEMENT
• BACILLUS CEREUS SELECTIVE AGAR BASE

Polymyxin B Sulfate

CAS: 1404-26-8, 1405-20-5

Cor e Forma: White to Light yellow powder to crystal

Ref: 3B-P1923

Polymixin B sulfate, Cell Culture Reagent

CAS: 1405-20-5

Polymixin B sulfate, 1405-20-5, is a polypeptide antibiotic which exhibits activity against gram-negative bacteria. Learn more at Thermo Fisher Scientific.

Fórmula: C₄₈H₈₄N₁₆O₁₇S

Cor e Forma: White to pale yellow, Powder

Peso molecular: 1189.36

Ref: 02-J61763

Polymixin B sulfate

CAS: 1405-20-5

Polymixin B sulfate, 1405-20-5, is a polypeptide antibiotic which exhibits activity against gram-negative bacteria. Learn more at Thermo Fisher Scientific.

Fórmula: C₄₈H₈₄N₁₆O₁₇S

Cor e Forma: Powder or crystalline powder, White to pale yellow

Peso molecular: 1189.36

Ref: 02-J63074

POLYMYXIN B SULFATE FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1405-20-5

POLYMYXIN B SULFATE FOR MICROBIOLOGICAL ASSAY CRS

Fórmula: C₅₆H₁₀₀N₁₆O₁₇S

Peso molecular: 1301.555

Ref: 41-Y0000355

Polymyxin B sulfate

CAS: 1405-20-5

Polymyxin B sulfate

Cor e Forma: Colourless

Ref: 47-1028

SECOND INTERNATIONAL STANDARD FOR POLYMYXIN B

CAS: 1405-20-5

SECOND INTERNATIONAL STANDARD FOR POLYMYXIN B

Fórmula: C₅₆H₁₀₀N₁₆O₁₇S

Peso molecular: 1301.555

Ref: 41-ISA_67_301

POLYMYXIN B SULFATE CRS

CAS: 1405-20-5

POLYMYXIN B SULFATE CRS

Ref: 41-P2400000

Polymyxin B Sulfate

CAS: 1405-20-5

Antibiotics nesoi

Fórmula: C₅₆H₉₈N₁₆O₁₃C₅₅H₉₆N₁₆O₁₃C₅₅H₉₆N₁₆O₁₃C₅₆H₉₈N₁₆O₁₃

Cor e Forma: White Off-White Powder

Peso molecular: 4782.96841

Ref: 45-1547007

Polymyxin B, sulfate (salt)

CAS: 1405-20-5

Fórmula: C₅₆H₁₀₀N₁₆O₁₇S

Cor e Forma: Solid

Peso molecular: 1301.5552

Ref: IN-DA001CJX

Polymyxin B Sulfate

CAS: 1405-20-5

Polymyxin B Sulfate, a mix of B1 and B2 from Bacillus polymyxa, fights gram-negative infections but may harm nerves and kidneys.

Fórmula: C₅₆H₁₀₀N₁₆O₁₇S

Pureza: 8010u/mg - 98%

Cor e Forma: White Crystalline Powder

Peso molecular: 1301.56

Ref: TM-T1100

Polymixin B sulphate

CAS: 1405-20-5

Polymixin B sulphate

Fórmula: C₅₆H₉₈N₁₆O₁₃·H₂SO₄

Cor e Forma: white to almost white powder

Peso molecular: 1,301.56g/mol

Ref: 54-BIP0145

Polymixin B sulfate salt

CAS: 1405-20-5

Fórmula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄

Pureza: ≥ 6000IU/mg (dried basis)

Cor e Forma: White to pale yellow powder

Peso molecular: 1385.63

Ref: 7W-GA4910

Polymyxin B Sulfate

CAS: 1405-20-5

Polymyxin B Sulfate

Pureza: ≥98%

Peso molecular: 1301.56g/mol

Ref: 54-BUP19624

Polymyxin B sulfate

Produto Controlado

CAS: 1405-20-5

Fórmula: C₅₅H₉₆N₁₆O₁₃· 2H₂SO₄

Cor e Forma: Neat

Peso molecular: 1385.61

Ref: 04-C16283000

Polymyxin B Sulfate

CAS: 1405-20-5

Fórmula: C₅₆H₉₈N₁₆O₁₃·H₂O₄S

Peso molecular: 1203.50 98.07

Ref: 4Z-PP-321010

Polymyxin B1 Formate Salt

Produto Controlado

CAS: 1405-20-5

Fórmula: C₅₆H₉₈N₁₆O₁₃·xHCOOH

Cor e Forma: Off-White

Peso molecular: 1203.48 + x46.03

Ref: TR-P689406

Polymyxin B Sulfate

CAS: 1405-20-5

Applications Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixture of Polymyxin B1 and B2 sulfate.
References Coppi, G., et al.: J. Pharm. Pharmacol., 60, 21 (2008), Roche, S., et al.: Food Microbiol., 26, 21 (2008), Kawanishi, T., et al.: Plant Pathol., 58, 237 (2009),

Fórmula: C₅₅H₉₆N₁₆O₁₃H₂SO₄

Cor e Forma: Neat

Peso molecular: 1385.61

Ref: TR-P689400

Polymyxin B sulfate

CAS: 1405-20-5

Membrane-disrupting agent

Fórmula: C₅₆H₉₈N₁₆O₁₃·H₂SO₄

Pureza: Min 6000 Iu/Mg

Cor e Forma: White Powder

Peso molecular: 1,301.56 g/mol

Ref: 3D-AP44829

Polymyxin B sulfate, Antibiotic for Culture Media Use Only

CAS: 1405-20-5

Polymyxin B is a sulfonamide antibiotic with broad spectrum of activity against Gram-negative bacteria. It binds to the bacterial membrane, causing an increase in the cell’s permeability and thus leading to cell death. A study on human neutrophils showed that polymyxin B reduces the expression of neomycin sulfate through inhibition of protein synthesis, which leads to cell death by lysosomal enzyme release. This antibiotic has been shown to be effective on clostridium perfringens, where it inhibits bacterial growth and leads to hypersensitivity reactions in some patients.

Fórmula: C₅₅H₁₀₀N₁₆O₂₁S₂

Pureza: Min. 90.0 Area-%

Peso molecular: 1,385.61 g/mol

Ref: 3D-P-7010

Polymyxin B Sulphate (Aerosporin, PXNS), 6000U/mg for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 1405-20-5

Fórmula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄

Pureza: min. 6000 units/mg

Cor e Forma: White to pale yellow, Powder

Peso molecular: 1385.61

Ref: SR-52819