CAS 142439-99-4

4-metilumbeliferil-7-(6-sulfo-2-*acetamido-2-de

Descrição:

4-Metilumbeliferil-7-(6-sulfo-2-acetamido-2-desoxi-α-D-glucopiranosídeo), comumente referido como um substrato fluorogênico, é um composto químico usado principalmente em ensaios bioquímicos, particularmente para a detecção de enzimas específicas. Este composto apresenta um grupo metilumbeliferil, conhecido por suas propriedades fluorescentes, permitindo uma detecção sensível quando clivado por enzimas como glicosidases. A presença de um grupo sulfonato aumenta sua solubilidade em soluções aquosas, tornando-o adequado para várias aplicações biológicas. Além disso, o grupo acetamido contribui para a estabilidade e especificidade do substrato. O composto é tipicamente utilizado em ambientes de pesquisa para estudar a cinética e atividade enzimática, fornecendo uma ferramenta valiosa para entender o metabolismo de carboidratos e as vias bioquímicas relacionadas. Sua natureza fluorescente permite o monitoramento em tempo real das reações enzimáticas, tornando-o um reagente essencial em biologia molecular e bioquímica. O manuseio e as condições de armazenamento adequados são necessários para manter sua integridade e eficácia em aplicações experimentais.

Fórmula: C₁₈H₂₀NNaO₁₁S

InChI: InChI=1/C18H21NO11S.Na/c1-8-5-14(21)29-12-6-10(3-4-11(8)12)28-18-15(19-9(2)20)17(23)16(22)13(30-18)7-27-31(24,25)26;/h3-6,13,15-18,22-23H,7H2,1-2H3,(H,19,20)(H,24,25,26);/q;+1/p-1/t13-,15-,16-,17-,18-;/m1./s1

SMILES: Cc1cc(=O)oc2cc(ccc12)OC1C(C(C(C(COS(=O)(=O)O)O1)O)O)N=C(C)O.[Na]

Sinónimos:

• sodium [(2R,3S,4R,5R,6S)-5-acetamido-3,4-dihydroxy-6-(4-methyl-2-oxo-chromen-7-yl)oxy-tetrahydropyran-2-yl]methyl sulfate

4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside 6-sulphate sodium salt

CAS: 142439-99-4

Fórmula: C₁₈H₂₀NNaO₁₁S

Peso molecular: 481.40

Ref: 7W-GC5948

4-Methylumbelliferyl-2-acetamido-2-deoxy-6-sulphate-β-D-glucopyranoside sodium salt

CAS: 142439-99-4

4-Methylumbelliferyl-2-acetamido-2-deoxy-6-sulphate-β-D-glucopyranoside sodium salt

Fórmula: C₁₈H₂₀NO₁₁S·Na

Pureza: 99% (by tlc) (Typical Value in Batch COA)

Cor e Forma: off white powder

Peso molecular: 481.41g/mol

Ref: 54-BIM1189

4-Methylumbelliferyl-N-acetyl-β-D-glucosaminide-6-sulfate, sodium salt

CAS: 142439-99-4

4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt is a high-quality fluorogenic substrate specifically designed for the detection and quantification of various enzymes, including beta-glucosidases and sulfatases. Upon hydrolysis by the target enzyme, this substrate releases the highly fluorescent 4-methylumbelliferone, allowing for real-time monitoring and accurate measurement of enzyme activities in biochemical assays, diagnostic tests, and research applications. 4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt has excellent solubility in water, ensuring a consistent and reliable performance in different experimental conditions. This versatile substrate is an essential tool for researchers and industry professionals who require a sensitive and reproducible detection method for enzymes of interest.

Fórmula: C₁₈H₂₀NNaO₁₁S

Pureza: Min. 98.0 Area-%

Peso molecular: 481.41 g/mol

Ref: 3D-M-5505

4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside-6-sulfate sodium salt

CAS: 142439-99-4

4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt is a high-quality fluorogenic substrate specifically designed for the detection and quantification of various enzymes, including beta-glucosidases and sulfatases. Upon hydrolysis by the target enzyme, this substrate releases the highly fluorescent 4-methylumbelliferone, allowing for real-time monitoring and accurate measurement of enzyme activities in biochemical assays, diagnostic tests, and research applications. 4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt has excellent solubility in water, ensuring a consistent and reliable performance in different experimental conditions. This versatile substrate is an essential tool for researchers and industry professionals who require a sensitive and reproducible detection method for enzymes of interest.

Fórmula: C₁₈H₂₀NO₁₁SNa

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 481.41 g/mol

Ref: 3D-EM03271

4-Methylumbelliferyl 2-Acetamido-2-deoxy-b-D-glucopyranoside 6-Sulphate Sodium Salt

Produto Controlado

CAS: 142439-99-4

Applications 4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside 6-sulphate sodium salt is a fluorescent substrate for isoenzyme A of N-acetyl-β-D-glucosaminidase (Hexosaminidase A). It can also be used in biological study of characterization of the mutant β-subunit of β-hexosaminidase for dimer formation responsible for the adult form of Sandhoff disease with the motor neuron disease phenotype.
References Yamada, K., et al.: J Biochem, 153, 111 (2013)

Fórmula: C₁₈H₂₁NO₁₁S·Na

Cor e Forma: Neat

Peso molecular: 482.41

Ref: TR-M337660