CAS 142880-36-2

Ilomastat

Descrição:

Ilomastat, também conhecido pelo seu nome químico, é um composto sintético classificado como um inibidor de metaloproteinases de matriz (MMP). É pesquisado principalmente por suas potenciais aplicações terapêuticas no tratamento de várias doenças, incluindo câncer e condições fibróticas. A substância atua inibindo a atividade das MMPs, que são enzimas envolvidas na degradação dos componentes da matriz extracelular, influenciando assim os processos de remodelação e reparo dos tecidos. Ilomastat tem sido estudado por sua capacidade de reduzir a invasão tumoral e a metástase, limitando a degradação da matriz extracelular. Em termos de suas propriedades físicas, Ilomastat é tipicamente caracterizado por sua estrutura molecular específica, que inclui grupos funcionais que contribuem para sua atividade biológica. O composto é geralmente administrado de maneira controlada em ambientes clínicos, e sua farmacocinética, incluindo absorção, distribuição, metabolismo e excreção, são críticas para entender sua eficácia e perfil de segurança. A pesquisa em andamento continua a explorar seu potencial completo e mecanismos de ação em vários contextos terapêuticos.

Fórmula: C₂₀H₂₈N₄O₄

InChI: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

Chave InChI: InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N

SMILES: C([C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C(NC)=O)C=1C=2C(NC1)=CC=CC2

Sinónimos:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• (2R)-N~4~-hydroxy-N~1~-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
• (R)-N1-((S)-3-(1H-indol-3yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-Indol-3-Yl)-1-Methylcarbamoly-Ethyl]-2-Isobutyl-Succinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-
• Cs 610
• Galardin
• Galardin Tm
• Galardin, GM6001, Ilomastat
• Gm 6001
• Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

Illomastat

CAS: 142880-36-2

Fórmula: C₂₀H₂₈N₄O₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 388.4607

Ref: IN-DA00350G

Ilomastat

CAS: 142880-36-2

Ilomastat

Pureza: ≥95%

Peso molecular: 388.46g/mol

Ref: 54-BUP12328

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

CAS: 142880-36-2

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

Pureza: 98%

Peso molecular: 388.46g/mol

Ref: 54-OR1023104

Ilomastat

CAS: 142880-36-2

Fórmula: C₂₀H₂₈N₄O₄

Pureza: >95.0%(HPLC)(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 388.47

Ref: 3B-I1202

Ilomastat

CAS: 142880-36-2

Fórmula: C₂₀H₂₈N₄O₄

Peso molecular: 388.50

Ref: 7W-GK4753

Ilomastat

CAS: 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Fórmula: C₂₀H₂₈N₄O₄

Pureza: 97.04% - 99.51%

Cor e Forma: Solid

Peso molecular: 388.46

Ref: TM-T2743

Ilomastat

Produto Controlado

CAS: 142880-36-2

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Fórmula: C₂₀H₂₈N₄O₄

Cor e Forma: Neat

Peso molecular: 388.46

Ref: TR-I267180

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

CAS: 142880-36-2

Pureza: 95%+

Peso molecular: 388.4679871

Ref: 10-F868898

GM 6001

CAS: 142880-36-2

GM 6001 is a matrix that contains benzalkonium chloride. It is used as a pharmacological agent to prevent the growth of bacteria, fungi, and viruses. This product inhibits the synthesis of proteins that are required for cell division and may cause neuronal death. GM 6001 has been shown to inhibit the expression of matrix metalloproteinase-9 (MMP-9) in cultured cells, which may be due to its interference with the synthesis of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α). GM 6001 also has potent immunosuppressive properties by inhibiting toll-like receptors (TLRs) in macrophages and dendritic cells. The TLRs are important for initiating immune responses against pathogens.

Fórmula: C₂₀H₂₈N₄O₄

Pureza: Min. 95%

Peso molecular: 388.46 g/mol

Ref: 3D-SFA88036

Galardinᵀᴹ

CAS: 142880-36-2

Galardinâ„¢ is an experimental drug with inhibitory properties, which can be used as a potential drug target to treat various diseases. It inhibits the polymerase chain reaction by binding to the enzyme DNA polymerase and preventing its activity. Galardinâ„¢ also has been shown to have protective effects against oxidative injury in 3T3-L1 preadipocytes and protect cells from cell death by inhibiting toll-like receptor signaling pathways. In addition, it has antimicrobial activity against Candida glabrata and other bacterial strains, such as Staphylococcus aureus and Acinetobacter baumannii.

Fórmula: C₂₀H₂₈N₄O₄

Pureza: Min. 95%

Peso molecular: 388.47 g/mol

Ref: 3D-INH-3927-PI