CAS 143201-11-0

Rivastatina

Descrição:

Rivastatina, com o número CAS 143201-11-0, é um composto sintético classificado principalmente como uma estatina, que é uma classe de medicamentos usados para reduzir os níveis de colesterol no sangue. Funciona inibindo a enzima HMG-CoA redutase, que desempenha um papel crucial na biossíntese do colesterol. Rivastatina é caracterizado por sua capacidade de reduzir o colesterol de lipoproteínas de baixa densidade (LDL) e triglicerídeos, enquanto potencialmente aumenta o colesterol de lipoproteínas de alta densidade (HDL). O composto é tipicamente administrado por via oral e é conhecido por seu perfil farmacocinético favorável, incluindo boa absorção e metabolismo. Rivastatina também pode exibir propriedades anti-inflamatórias e antioxidantes, contribuindo para a saúde cardiovascular além do manejo do colesterol. Assim como outras estatinas, pode ter efeitos colaterais, incluindo dor muscular e alterações nas enzimas hepáticas, necessitando de monitoramento durante o tratamento. No geral, Rivastatina representa uma opção terapêutica significativa no manejo da dislipidemia e na redução do risco de doenças cardiovasculares.

Fórmula: C₂₆H₃₄FNO₅

InChI: InChI=1/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1

Chave InChI: InChIKey=UVXVKMCFVDNBCD-QCVDVZFFSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=C(COC)C(C(C)C)=NC1C(C)C)C2=CC=C(F)C=C2.[Na]

Sinónimos:

• (+)-Sodium (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoate
• 6-Heptanoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-(S-(R*,S*-(E)))-, sodium salt
• 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-
• 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (S-(R*,S*-(E)))-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, monosodium salt, [R-[R*,S*-(E)]]-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, sodium salt (1:1), (3R,5S,6E)-
• 7-(4-(4-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyrid-3-yl)-3,5-dihydroxy-6-heptenoate sodium salt
• Bay w 6228
• Baycol
• Lipobay
• Rivastatin
• Unii-6Q18G1060S
• sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate
• Cerivastatin sodium
• CERIVASTATIN
• Rivastatin, Baycol, Lipobay

Cerivastatin, Sodium Salt

CAS: 143201-11-0

Fórmula: C₂₆H₃₃FNNaO₅

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 481.5321

Ref: IN-DA007Z1N

Sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoate

CAS: 143201-11-0

Sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoate

Pureza: 99%

Peso molecular: 481.54g/mol

Ref: 54-PC1007894

Cerivastatin Sodium Salt

CAS: 143201-11-0

Fórmula: C₂₆H₃₃FNO₅·Na

Cor e Forma: White To Off-White Solid

Peso molecular: 458.56 22.99

Ref: 4Z-C-328001

Cerivastatin sodium salt hydrate

CAS: 143201-11-0

Fórmula: C₂₆H₃₃FNNaO₅·xH₂O

Pureza: ≥ 97.0% (anhydrous basis)

Cor e Forma: White, off-white or pale yellow powder

Peso molecular: 481.53 (anhydrous)

Ref: 7W-GP6776

Cerivastatin-13C-d3 Sodium Salt

CAS: 143201-11-0

Fórmula: CC₂₅H₃₀D₃FNO₅·Na

Cor e Forma: Off-White Solid

Peso molecular: 462.56 22.99

Ref: 4Z-C-328002

Cerivastatin sodium

CAS: 143201-11-0

Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.

Fórmula: C₂₆H₃₃FNNaO₅

Pureza: 98.50% - 99.67%

Cor e Forma: Solid

Peso molecular: 481.53

Ref: TM-T10767

Cerivastatin Sodium Salt

Produto Controlado

CAS: 143201-11-0

Stability Hygroscopic
Applications Cerivastatin is a competitive inhibitor of HMG-CoA reductase.
References Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996), Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996),

Fórmula: C₂₆H₃₃FNO₅·Na

Cor e Forma: White To Off-White

Peso molecular: 481.53

Ref: TR-C277000

Cerivastatin sodium - Bio-X ™

CAS: 143201-11-0

Cerivastatin is a drug that belongs to the class of drugs called statins. This drug is used to reduce the risk of cardiovascular events and lower lipid levels. Cerivastatin is an HMG-CoA reductase inhibitor and allows for a decrease in cholesterol in hepatic cells. Cerivastatin is cardioprotective and anti-atherosclerotic.

Fórmula: C₂₆H₃₃FNNaO₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 481.53 g/mol

Ref: 3D-BC300049

Cerivastatin sodium

CAS: 143201-11-0

An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that reduces total cholesterol and low-density lipoprotein (LDL). Cerivastatin is cardioprotective and anti-atherosclerotic. Cerivastatin inhibits the expression of the atherosclerotic genes monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2), whilst inducing the expression of Kruppel-like factor 2 (KLF2).

Fórmula: C₂₆H₃₃FNNaO₅

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 481.53 g/mol

Ref: 3D-FC19906