CAS 143484-41-7

(2R)-4-{[(2Z)-2-(6-chloro-3-oxo-2-benzofuran-1(3H)-ylidene)ethyl]oxy}-N,N,N-trimethyl-2-[(3-methylbutanoyl)oxy]-4-oxobutan-1-aminium bromide

Fórmula: C₂₂H₂₉BrClNO₆

InChI: InChI=1/C22H29ClNO6.BrH/c1-14(2)10-21(26)29-16(13-24(3,4)5)12-20(25)28-9-8-19-18-11-15(23)6-7-17(18)22(27)30-19;/h6-8,11,14,16H,9-10,12-13H2,1-5H3;1H/q+1;/p-1/b19-8-;/t16-;/m1./s1

ST-899

CAS: 143484-41-7

ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.

Fórmula: C₂₂H₂₉BrClNO₆

Cor e Forma: Solid

Peso molecular: 518.83

Ref: TM-T211047