CAS 14362-31-3

Clorclizina hidrocloridrato

Descrição:

Clorclizina hidrocloridrato é um antihistamínico pertencente à classe dos diphenylmethane, utilizado principalmente por suas propriedades anti-alérgicas. É caracterizado por sua capacidade de bloquear os receptores de histamina H1, aliviando assim os sintomas associados a reações alérgicas, como febre do feno e urticária. O composto aparece como um pó cristalino branco a off-white e é solúvel em água, tornando-o adequado para várias formulações farmacêuticas. Clorclizina hidrocloridrato apresenta uma duração de ação relativamente longa, o que contribui para sua eficácia no manejo dos sintomas alérgicos. Além disso, pode ter efeitos sedativos, uma característica comum entre os antihistamínicos de primeira geração, o que pode levar à sonolência em alguns indivíduos. A substância é tipicamente administrada por via oral e está disponível em várias formas de dosagem, incluindo comprimidos e xaropes. Assim como qualquer medicamento, é essencial considerar os possíveis efeitos colaterais, como boca seca, tontura e distúrbios gastrointestinais, e usá-lo sob supervisão médica para garantir segurança e eficácia.

Fórmula: C₁₈H₂₁ClN₂·ClH

InChI: InChI=1S/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H

Chave InChI: InChIKey=MSIJLVMSKDXAQN-UHFFFAOYSA-N

SMILES: C(C1=CC=C(Cl)C=C1)(N2CCN(C)CC2)C3=CC=CC=C3.Cl

Sinónimos:

• 1-(P-Chloro-Alpha-Phenylbenzyl)-4-Methyl-Piperazinhydrochloride
• 1-(P-Chloro-Alpha-Phenylbenzyl)-4-Methylpiperazinehydrochloride
• 1-(P-Chlorobenzhydryl)-4-Methylpiperazinehydrochloride
• 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine hydrochloride
• 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine monohydrochloride
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-Methylpiperazine
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-Methylpiperazine Hydrochloride (1:1)
• 1-[(4-Chlorophenyl)Phenyl-Methyl]-4-Methylpiperazine Hydrochloride
• Chlorcyclizine HCL
• Chlorcyclizine chloride
• Chlorcyclizine monohydrochloride
• Chlorcycliziniumchloride
• Di-Paralene
• Eramide
• Histantin
• Mantadil
• NSC 169496
• Perazil
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-, hydrochloride
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-, monohydrochloride
• Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-, hydrochloride
• Piperazine, 1-(p-chloro-α-phenylbenzyl)-4-methyl-, monohydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-, hydrochloride (1:1)
• Unii-Npb7A7874U

Chlorcyclizine Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 14362-31-3

Cor e Forma: Single Solution

Ref: 61-AMP1653.00-01

CHLORCYCLIZINE HYDROCHLORIDE CRS

CAS: 14362-31-3

CHLORCYCLIZINE HYDROCHLORIDE CRS

Fórmula: C₁₈H₂₂Cl₂N₂

Cor e Forma: Crystalline Powder. White. Yellow. Powder.

Peso molecular: 337.2867

Ref: 41-C1435000

Chlorcyclizine Hydrochloride

Produto Controlado

CAS: 14362-31-3

Fórmula: C₁₈H₂₁ClN₂·ClH

Cor e Forma: Neat

Peso molecular: 337.29

Ref: 86-MM1653.00

Chlorcyclizine Hydrochloride

CAS: 14362-31-3

Cor e Forma: Neat

Ref: 61-FOR1653.00

Chlorcyclizine HCl

CAS: 14362-31-3

Fórmula: C₁₈H₂₁ClN₂·HCl

Peso molecular: 300.83 36.46

Ref: 4Z-C-332001

Chlorcyclizine hydrochloride

Produto Controlado

CAS: 14362-31-3

Chlorcyclizine hydrochloride is a potent inhibitor of the growth factor-β1 receptor. It also has antimicrobial activity and can be used as an antiseptic, especially for the treatment of eye infections. Chlorcyclizine hydrochloride is a potent inducer of toll-like receptor 4 (TLR4) which is responsible for innate immunity against bacteria and fungi. This drug also inhibits propranolol hydrochloride binding to the β2-adrenergic receptor, which may lead to cardiotoxicity in some patients. The compound has shown significant cytotoxicity on liver cells in vitro, but not on other cell lines; this toxicity may be due to its ability to react with iodides in solution, forming reactive intermediates that cause cellular damage.

Fórmula: C₁₈H₂₂Cl₂N₂

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 337.29 g/mol

Ref: 3D-FC178661

Chlor Cyclizine-d4 Dihydrochloride

Produto Controlado

CAS: 1246911-79-4, 14362-31-3

Fórmula: C₁₈H₁₇D₄ClN₂•2HCl

Cor e Forma: Neat

Peso molecular: 304.85 + 2(36.46)

Ref: TR-C326504

Chlor Cyclizine Hydrochloride

Produto Controlado

CAS: 14362-31-3

Applications An antihistaminic drug. A drug analog of Cyclizine (C987805).
References Leurs, R., et al.: Pharmacol. Ther., 66, 413 (1995), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999), Church, M., et al.: Clin. Exp. Allergy, 31, 1341 (2001),

Fórmula: C₁₈H₂₁ClN₂·ClH

Cor e Forma: Off-White

Peso molecular: 337.29

Ref: TR-C326500

Chlorcyclizine hydrochloride

CAS: 14362-31-3

Chlorcyclizine hydrochloride

Fórmula: C₁₈H₂₂Cl₂N₂

Cor e Forma: Off-White

Peso molecular: 337.2867

Ref: 47-67