CAS 144120-54-7

1-(2-Propen-1-il) hidrogênio N-[(9H-fluoren-9-ilmetoxi)carbonil]-L-glutamato

Descrição:

1-(2-Propen-1-il) hidrogênio N-[(9H-fluoren-9-ilmetoxi)carbonil]-L-glutamato, com número CAS 144120-54-7, é um composto sintético utilizado principalmente em química de peptídeos e aplicações de bioconjugação. Esta substância apresenta um grupo propenila, que contribui para sua reatividade, particularmente em reações de adição de Michael. A presença do grupo protetor fluorenilmetoxicarbonila (Fmoc) indica sua utilidade na síntese de peptídeos em fase sólida, onde serve para proteger o grupo amino de L-glutamato durante o processo de síntese. O composto é caracterizado por sua capacidade de passar por várias transformações químicas, tornando-o valioso no desenvolvimento de terapias baseadas em peptídeos. Além disso, exibe solubilidade em solventes orgânicos, o que é típico para compostos que contêm grupos aromáticos. Sua complexidade estrutural permite interações específicas em sistemas biológicos, potencialmente influenciando suas propriedades farmacológicas. No geral, este composto é significativo no campo da química medicinal e síntese de peptídeos, facilitando a criação de biomoléculas complexas para fins de pesquisa e terapêuticos.

Fórmula: C₂₃H₂₃NO₆

InChI: InChI=1/C23H23NO6/c1-2-13-29-22(27)20(11-12-21(25)26)24-23(28)30-14-19-17-9-5-3-7-15(17)16-8-4-6-10-18(16)19/h2-10,19-20H,1,11-14H2,(H,24,28)(H,25,26)/t20-/m0/s1

Chave InChI: InChIKey=ORKKMGRINLTBPC-FQEVSTJZSA-N

SMILES: C(OC(N[C@H](C(OCC=C)=O)CCC(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Sinónimos:

• (4S)-4-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-prop-2-enoxypentanoic acid
• (4S)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxo-5-(prop-2-en-1-yloxy)pentanoic acid (non-preferred name)
• 1-(2-Propen-1-yl) hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-glutamate
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(2-propen-1-yl) ester
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(2-propenyl) ester
• Fmoc-Glu-OAll
• Fmoc-Glu-allyl ester
• Fmoc-L-glutamic acid α-allyl ester
• 1-(2-Propen-1-yl) hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate
• L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(2-propen-1-yl) ester
• L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(2-propenyl) ester
• FMOC-GLUTAMIC ACID-ALLYL ESTER
• N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMIC-ACID-ALPHA ALLYL ESTER
• FMOC-GLU-OAL
• FMOC-GLU(OME)-OH
• FMOC-L-GLUTAMIC ACID ALPHA-ALLYL ESTER
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMIC ACID ALPHA-ALLYL ESTER
• N-ALPHA-FMOC-L-GLUTAMIC ACID ALPHA-ALLYL ESTER
• FMOC-L-GLUTAMIC ACID 1-ALLYL ESTER

1-Allyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamate

CAS: 144120-54-7

Fórmula: C₂₃H₂₃NO₆

Pureza: >96.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 409.44

Ref: 3B-A2909

N-Fmoc-L-glutamic acid 1-allyl ester, 98%

CAS: 144120-54-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₂₃H₂₃NO₆

Pureza: 98%

Peso molecular: 409.44

Ref: 02-H66448

Fmoc-Glu-allyl ester

CAS: 144120-54-7

α-Allyl esters are of special interest, because they are a useful tool for the on-resin synthesis of head-to-tail cyclic peptides, side-chain lactam peptides, glyco- and sulfo-peptides, and branched peptides. Allyl esters are cleaved quantitatively under mild conditions using Pd(0). These conditions are compatible with Fmoc- and Boc-SPPS. Fmoc-Glu-OAll is a versatile educt for the synthesis of N-modified glutamines. Due to the lack of steric hindrance of the allyl group, prolonged treatment with harsher Fmoc cleavage agents or even piperidine may induce side-reactions as glutarimide formation, as observed by Zhu and Marchant.

Fórmula: C₂₃H₂₃NO₆

Pureza: 99.03%

Cor e Forma: White Powder

Peso molecular: 409.44

Ref: 01-4026433

L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(2-propen-1-yl) ester

CAS: 144120-54-7

Fórmula: C₂₃H₂₃NO₆

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 409.4318

Ref: IN-DA001IZI

Fmoc-L-Glutamic Acid 1-Allyl Ester

CAS: 144120-54-7

Fmoc-L-Glutamic Acid 1-Allyl Ester

Pureza: 98%

Peso molecular: 409.43g/mol

Ref: 54-OR1013369

Fmoc-Glu-OAll

CAS: 144120-54-7

Fórmula: C₂₃H₂₃NO₆

Peso molecular: 409.43

Ref: 7W-GM2584

Fmoc-L-glutamic acid 1-allyl ester

CAS: 144120-54-7

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 409.44

Ref: 10-M06240

Fmoc-glu-OAll

CAS: 144120-54-7

Fmoc-glu-OAll is a cyclic peptide that is synthesized using solid-phase synthesis. It has been shown to have minimal inhibitory concentration (MIC) values of 0.5 µg/mL against mouse tumor cells and human serum, as well as high affinity for integrin receptors. This peptide also binds to the human serum albumin and blood clotting factor Xa, which are proteins involved in cancer therapy.

Fórmula: C₂₃H₂₃NO₆

Pureza: Min. 95%

Peso molecular: 409.43 g/mol

Ref: 3D-FF41629