CAS 144750-42-5

Composto Relacionado A de Clopidogrel USP

Descrição:

Composto Relacionado A de Clopidogrel USP, com o número CAS 144750-42-5, é uma substância química que está estruturalmente relacionada ao medicamento antiplaquetário clopidogrel. É caracterizada principalmente por seu papel como impureza ou produto de degradação na síntese do clopidogrel. Este composto é tipicamente identificado através de técnicas analíticas como cromatografia líquida de alta eficiência (HPLC) e espectrometria de massas. Sua estrutura molecular apresenta grupos funcionais específicos que contribuem ao seu comportamento químico e estabilidade. O clopidogrel em si é um pró-fármaco que requer ativação metabólica para exercer seus efeitos farmacológicos, e compostos relacionados como o Composto A podem apresentar diferentes graus de atividade biológica ou toxicidade. A presença de tais compostos relacionados é importante para o controle de qualidade nas formulações farmacêuticas, pois podem influenciar a eficácia e segurança do produto final. Diretrizes regulatórias frequentemente ditam os limites aceitáveis para essas impurezas para garantir a segurança do paciente e a eficácia do medicamento.

Fórmula: C₁₅H₁₄ClNO₂S·ClH

InChI: InChI=1S/C15H14ClNO2S.ClH/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13;/h1-4,6,8,14H,5,7,9H2,(H,18,19);1H/t14-;/m0./s1

Chave InChI: InChIKey=FOKSIOUPGDBSLC-UQKRIMTDSA-N

SMILES: [C@H](C(O)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.Cl

Sinónimos:

• (+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride
• (2S)-(2-Chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride (1:1)
• (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
• (αS)-α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride (1:1)
• Clopidogrel Related Compound A
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride, (αS)-
• Clopidogrel Related Compound A (20 mg) ((S)-(ochlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-aceticv acid, hydrochloride)
• Clopidogrel Impurity 1 HCl(Clopidogrel EP Impurity A HCl)
• CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
• Clopidogrel carboxylic acid Impurity
• Clopidogrel USP Related CoMpound A
• Clopidogrel Related Compound A as Hydrochloride
• Clopidogrel Impurity 2/Clopidogrel EP Impurity A HCl/(S)-Clopidogrel Acid Hydrochloride/(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
• Clopidogrel USP Related Compound A as Hydrochloride
• alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride
• Clopidogrel Hydrogen Sulfate EP Impurity A as Hydrochloride
• (+)-(S)-(o-Chlorophenyl)-6,7-dihydrothieno3,2-cpyridine-5(4H)-acetic acid hydrochloride
• Clopidogrel USP RC A
• Clopidogrel Hydrogen Sulfate Impurity A as Hydrochloride
• (S)-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride
• (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride? (Clopidogrel Impurity）
• Clopidogrel acid hydrochloride
• Clopidogrel EP Impurity A HCl
• Clopidogrel EP IMpurity-A
• Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-ace (1140586)
• Clopidogrel Carboxylic Acid Hydrochloride Salt
• Clopidogrel Impurity A（EP）
• Clopidogrel Related Compound A (H0M124)
• Clopidogrel EP impurity-A (USP RC A)
• Clopidogrel Carboxylic Acid Hydrochloride

CLOPIDOGREL IMPURITY A CRS

CAS: 144750-42-5

CLOPIDOGREL IMPURITY A CRS

Ref: 41-Y0001335

Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride)

CAS: 144750-42-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₅H₁₄ClNO₂S·HCl

Cor e Forma: Off-White Powder

Peso molecular: 307.04338

Ref: 45-1140586

Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-

CAS: 144750-42-5

Fórmula: C₁₅H₁₅Cl₂NO₂S

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 344.2561

Ref: IN-DA001K3J

(S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-c]Pyridin-5(4H)-Yl)Acetic Acid Hydrochloride

CAS: 144750-42-5

(S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-c]Pyridin-5(4H)-Yl)Acetic Acid Hydrochloride

Pureza: 98%

Peso molecular: 344.26g/mol

Ref: 54-OR1028086

(2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogrel Acid Hydrochloride)

CAS: 144750-42-5

Cor e Forma: Neat

Ref: 86-MM0455.04

(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

CAS: 144750-42-5

Pureza: 95.0%

Peso molecular: 344.25

Ref: 10-F237891

Clopidogrel Carboxylic Acid hydrochloride

CAS: 144750-42-5

Clopidogrel Carboxylic Acid hydrochloride (SR 26334) is a major inactive metabolite of clopidogrel, commonly used as a reference standard for metabolic analysi.

Fórmula: C₁₅H₁₅Cl₂NO₂S

Pureza: 99.32%

Cor e Forma: Solid

Peso molecular: 344.26

Ref: TM-T36112

Clopidogrel Carboxylic Acid Hydrochloride

Produto Controlado

CAS: 144750-42-5

Impurity Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A
Stability Hygroscopic
Applications Clopidogrel Carboxylic Acid Hydrochloride (Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A) is the hydrochloride salt of a metabolite of the drug Clopidogrel.
References Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Pereillo, J., et al.: Drug Metab. Dispos., 30, 1288 (2002), Ksycinska, H., et al.: J. Pharm. Biomed. Anal., 41, 533 (2006), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007),

Fórmula: C₁₅H₁₄ClNO₂S·ClH

Cor e Forma: Light Yellow

Peso molecular: 344.26

Ref: TR-C587235

(R)- Clopidogrel Carboxylic Acid Hydrochloride

Produto Controlado

CAS: 144750-42-5

Fórmula: C₁₅H₁₄ClNO₂S·HCl

Cor e Forma: Neat

Peso molecular: 344.26

Ref: TR-C587231

Clopidogrel Impurity A

CAS: 144750-42-5

Clopidogrel Impurity A is a medicine that is used for the prevention of heart attacks, strokes, and blood clots in people with an increased risk of these events. It is not intended to be used for immediate relief from sudden symptoms. Clopidogrel Impurity A is a substance that may be found in some preparations of clopidogrel. The presence of this substance can be detected by liquid chromatography-mass spectrometry (LC-MS/MS) methods. The structural analysis of this substance was determined using enantiomeric resolution and chromatographic methods. This impurity has been shown to have no effect on the bioavailability of the parent drug, clopidogrel, when given orally to Sprague-Dawley rats.

Fórmula: C₁₅H₁₅Cl₂NO₂S

Pureza: Min. 95%

Peso molecular: 344.26 g/mol

Ref: 3D-IC158706