CAS 146478-72-0

(2Z,4S)-4-(Acetiloxi)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-diidroxi-7-metil-1,6-dioxaspiro[2.5]oct-5-il]-3-metil-2,4-pentadien-1-il]tetraidro-2,5-dimetil-2H-piran-3-il]-2-pentenamida

Descrição:

A substância química com o nome "(2Z,4S)-4-(Acetiloxi)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-diidroxi-7-metil-1,6-dioxaspiro[2.5]oct-5-il]-3-metil-2,4-pentadien-1-il]tetraidro-2,5-dimetil-2H-piran-3-il]-2-pentenamida" e número CAS "146478-72-0" é um composto orgânico complexo caracterizado por múltiplos grupos funcionais e estereocentros. Apresenta um grupo acetyloxy, o que sugere reatividade e solubilidade potencial em solventes orgânicos. A presença de uma estrutura dioxaspiro indica um arranjo cíclico único que pode contribuir para sua atividade biológica. O composto também contém múltiplos centros quirais, que podem influenciar sua estereoquímica e interações com sistemas biológicos. Sua estrutura sugere aplicações potenciais em farmacêuticos ou como um composto bioativo, embora atividades biológicas específicas exijam investigação adicional. O intrincado arranjo de cadeias de carbono e grupos funcionais destaca sua complexidade, tornando-o um assunto de interesse na química orgânica sintética e na pesquisa em química medicinal.

Fórmula: C₂₇H₄₁NO₈

InChI: InChI=1S/C27H41NO8/c1-16(8-11-23-25(31)27(15-33-27)14-26(6,32)36-23)7-10-22-17(2)13-21(19(4)35-22)28-24(30)12-9-18(3)34-20(5)29/h7-9,11-12,17-19,21-23,25,31-32H,10,13-15H2,1-6H3,(H,28,30)/b11-8+,12-9-,16-7+/t17-,18-,19+,21+,22-,23+,25+,26-,27+/m0/s1

Chave InChI: InChIKey=PJKVJJDQXZARCA-QHYZBLTGSA-N

SMILES: O[C@H]1[C@]2(CO2)C[C@@](C)(O)O[C@@H]1/C=C/C(=C/C[C@H]3[C@@H](C)C[C@@H](NC(/C=C\[C@@H](OC(C)=O)C)=O)[C@@H](C)O3)/C

Sinónimos:

• 2-Pentenamide, 4-(acetyloxy)-N-[6-[5-(4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl)-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, [3R-[3R*,4R*,5R*[1[2R*,3R*(2Z,4S*),5S*,6S*],2E,4E],7S*]]-
• (2Z,4S)-4-(Acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-2-pentenamide
• WB 2663B
• 2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-
• 2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-

FR901464

CAS: 146478-72-0

FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring.

Fórmula: C₂₇H₄₁NO₈

Pureza: 98.47%

Cor e Forma: Solid

Peso molecular: 507.62

Ref: TM-T31866

FR901464

CAS: 146478-72-0

FR901464

Pureza: ≥98%

Peso molecular: 507.62g/mol

Ref: 54-BUP01121

FR 901464

CAS: 146478-72-0

FR 901464 is a cytotoxic compound that inhibits the activity of the mammalian splicing factor receptor (SFRS2), which is involved in the splicing process. The active form of FR 901464 binds to SFRS2 and prevents it from binding to other proteins, thereby inhibiting the formation of functional complexes. This leads to an increase in the production of proteins that are not targeted for degradation and a decrease in the production of proteins targeted for degradation. This drug also has anti-inflammatory properties by inhibiting epidermal growth factor (EGF) and its receptor, EGF-R. It also has antimicrobial effects against some bacteria by inhibiting bacterial growth factors such as amide or conjugates.

Fórmula: C₂₇H₄₁NO₈

Pureza: Min. 95%

Peso molecular: 507.6 g/mol

Ref: 3D-WFA47872