CAS 146897-68-9

Lactoferricina B

Descrição:

Lactoferricina B é um peptídeo derivado da lactoferrina, uma glicoproteína encontrada em vários fluidos secretórios, incluindo o leite. É conhecido por suas propriedades antimicrobianas, exibindo atividade contra uma ampla gama de bactérias, fungos e vírus. A estrutura de Lactoferricina B consiste em uma sequência de aminoácidos que contribuem para sua capacidade de interromper as membranas microbianas, levando à lise celular. Este peptídeo também é reconhecido por seus efeitos imunomoduladores, melhorando a resposta imunológica e potencialmente desempenhando um papel na regulação da inflamação. Além disso, Lactoferricina B tem sido estudado por suas potenciais aplicações na preservação de alimentos e como agente terapêutico no tratamento de infecções. Sua estabilidade sob várias condições de pH e resistência a enzimas proteolíticas aumentam ainda mais sua utilidade tanto em ambientes clínicos quanto na indústria alimentícia. No geral, Lactoferricina B representa uma área significativa de interesse em bioquímica e farmacologia devido às suas propriedades multifuncionais e potenciais benefícios à saúde.

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

InChI: InChI=1/C141H226N46O29S3/c1-11-77(6)111(133(212)186-112(80(9)189)134(213)183-106(74-218)130(209)184-110(76(4)5)132(211)176-97(49-32-61-161-141(155)156)120(199)170-93(45-28-57-157-137(147)148)116(195)166-78(7)113(192)180-103(136(215)216)66-82-36-16-13-17-37-82)185-128(207)104(72-188)181-131(210)107-50-33-62-187(107)135(214)79(8)165-109(191)71-164-115(194)100(64-75(2)3)177-121(200)92(44-24-27-56-144)168-117(196)91(43-23-26-55-143)169-125(204)99(53-63-219-10)175-119(198)94(46-29-58-158-138(149)150)172-126(205)101(67-83-69-162-88-40-20-18-38-85(83)88)179-124(203)98(51-52-108(146)190)174-127(206)102(68-84-70-163-89-41-21-19-39-86(84)89)178-122(201)96(48-31-60-160-140(153)154)171-118(197)95(47-30-59-159-139(151)152)173-129(208)105(73-217)182-123(202)90(42-22-25-54-142)167-114(193)87(145)65-81-34-14-12-15-35-81/h12-21,34-41,69-70,75-80,87,90-107,110-112,162-163,188-189,217-218H,11,22-33,42-68,71-74,142-145H2,1-10H3,(H2,146,190)(H,164,194)(H,165,191)(H,166,195)(H,167,193)(H,168,196)(H,169,204)(H,170,199)(H,171,197)(H,172,205)(H,173,208)(H,174,206)(H,175,198)(H,176,211)(H,177,200)(H,178,201)(H,179,203)(H,180,192)(H,181,210)(H,182,202)(H,183,213)(H,184,209)(H,185,207)(H,186,212)(H,215,216)(H4,147,148,157)(H4,149,150,158)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161)/t77-,78-,79-,80+,87-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,110-,111-,112-/m0/s1

Sinónimos:

• L-Phenylalanine, L-phenylalanyl-L-lysyl-L-cysteinyl-L-arginyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-tryptophyl-L-arginyl-L-methionyl-L-lysyl-L-lysyl-L-leucylglycyl-L-alanyl-L-prolyl-L-seryl-L-isoleucyl-L-threonyl-L-cysteinyl-L-valyl-L-arginyl-L-arginyl-L-alanyl-
• Lactoferrin
• Lfn B

Lactoferricin B25

CAS: 146897-68-9

The antimicrobial peptide lactoferricin B25 is a fragment of cow’s milk protein lactoferrin. The peptide exhibits potent dose-dependent and time-dependent anticancer activity against human stomach cancer cell cultures via apoptosis and autophagy. LFcinB25 is expected to yield novel anticancer drugs.

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Pureza: > 95%

Cor e Forma: White Powder

Peso molecular: 3123.82

Ref: 01-4087382

Lactoferrin, from bovine milk

CAS: 146897-68-9

Ref: 7W-GX6595

Lactoferrin (17-41)

CAS: 146897-68-9

Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 3123.77

Ref: TM-TP1518

Lactoferrin (17-41) (Standard)

CAS: 146897-68-9

Lactoferrin (17-41) (Standard) is a reference material for analytical use. Lactoferrin (17-41) exhibits broad-spectrum antimicrobial activity.

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Peso molecular: 3123.77

Ref: TM-TMSM-1421

Lactoferrin

Produto Controlado

CAS: 146897-68-9

Applications Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells.
References Sánchez L. et al.: Arch. Dis. CHild., 67, 657 (1992); Harmsen MC. et al.: J. Infect. Dis., 172, 380 (1995);

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Cor e Forma: Neat

Peso molecular: 3123.8

Ref: TR-L113780

Lactoferrin

CAS: 146897-68-9

Lactoferrin is a multifunctional glycoprotein, which is primarily sourced from bovine milk, human milk, and other mammalian secretions. With its high affinity for iron, lactoferrin sequesters iron ions, which inhibits bacterial growth by depriving them of the iron necessary for proliferation. This mechanism enables lactoferrin to exhibit potent antimicrobial properties.

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 3,123.8 g/mol

Ref: 3D-FL181256

Lactoferricin B25

CAS: 146897-68-9

Lactoferricin B25 is a potent anticancer agent that has shown significant activity in vitro against cancer cell lines. It has been shown to induce apoptosis and autophagy, which are both methods of inducing cell death. Lactoferricin B25 also induces caspase-mediated apoptosis and has been shown to be effective in the treatment of cancer cells in vivo. Lactoferricin B25 binds with high affinity to the cell membrane, which is thought to be responsible for its anticancer activity. The half-maximal inhibitory concentration (IC50) for this compound is about 2 μM, with a concomitant cytotoxic effect at 10 μM. Lactoferricin B25 binds to DNA polymerase, preventing DNA replication and transcription. The binding of lactoferricin B25 to DNA polymerase inhibits the synthesis of RNA from DNA templates by inhibiting the elongation step of transcription.

Fórmula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Pureza: Min. 90 Area-%

Cor e Forma: Powder

Peso molecular: 3,123.78 g/mol

Ref: 3D-FL110082